Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations

Dirk Steinritz; Enno Striepling; Klaus-Dieter Rudolf; Claudia Schröder-Kraft; Klaus Püschel; Andreas Hullard-Pulstinger; Marianne Koller; Horst Thiermann; Felix Gandor; Michael Gawlik; Harald John

doi:10.1016/j.toxlet.2015.08.1105

Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations

Standard

Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations. / Steinritz, Dirk; Striepling, Enno; Rudolf, Klaus-Dieter; Schröder-Kraft, Claudia; Püschel, Klaus; Hullard-Pulstinger, Andreas; Koller, Marianne; Thiermann, Horst; Gandor, Felix; Gawlik, Michael; John, Harald.

in: TOXICOL LETT, Jahrgang 244, 26.02.2016, S. 112-20.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Steinritz, D, Striepling, E, Rudolf, K-D, Schröder-Kraft, C, Püschel, K, Hullard-Pulstinger, A, Koller, M, Thiermann, H, Gandor, F, Gawlik, M & John, H 2016, 'Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations', TOXICOL LETT, Jg. 244, S. 112-20. https://doi.org/10.1016/j.toxlet.2015.08.1105

APA

Steinritz, D., Striepling, E., Rudolf, K-D., Schröder-Kraft, C., Püschel, K., Hullard-Pulstinger, A., Koller, M., Thiermann, H., Gandor, F., Gawlik, M., & John, H. (2016). Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations. TOXICOL LETT, 244, 112-20. https://doi.org/10.1016/j.toxlet.2015.08.1105

Vancouver

Steinritz D, Striepling E, Rudolf K-D, Schröder-Kraft C, Püschel K, Hullard-Pulstinger A et al. Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations. TOXICOL LETT. 2016 Feb 26;244:112-20. https://doi.org/10.1016/j.toxlet.2015.08.1105

Bibtex

@article{603053803f414665922623376947df17,

title = "Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations",

abstract = "Sulfur mustard (SM) is a chemical warfare agent (CWA) that was first used in World War I and in several military conflicts afterwards. The threat by SM is still present even today due to remaining stockpiles, old and abandoned remainders all over the world as well as to its ease of synthesis. CWA are banned by the Chemical Weapons Convention (CWC) interdicting their development, production, transport, stockpiling and use and are subjected to controlled destruction. The present case report describes an accidental exposure of three workers that occurred during the destruction of SM. All exposed workers presented a characteristic SM-related clinical picture that started about 4h after exposure with erythema and feeling of tension of the skin at the upper part of the body. Later on, superficial blister and a burning phenomenon of the affected skin areas developed. Similar symptoms occurred in all three patients differing severity. One patient presented sustained skin affections at the gluteal region while another patient came up with affections of the axilla and genital region. Fortunately, full recovery was observed on day 56 after exposure except some little pigmentation changes that were evident even on day 154 in two of the patients. SM-exposure was verified for all three patients using bioanalytical GC MS and LC MS/MS based methods applied to urine and plasma. Urinary biotransformation products of the β-lyase pathway were detected until 5 days after poisoning whereas albumin-SM adducts could be found until day 29 underlining the beneficial role of adduct detection for post-exposure verification. In addition, we provide general recommendations for management and therapy in case of SM poisoning.",

author = "Dirk Steinritz and Enno Striepling and Klaus-Dieter Rudolf and Claudia Schr{\"o}der-Kraft and Klaus P{\"u}schel and Andreas Hullard-Pulstinger and Marianne Koller and Horst Thiermann and Felix Gandor and Michael Gawlik and Harald John",

year = "2016",

month = feb,

day = "26",

doi = "10.1016/j.toxlet.2015.08.1105",

language = "English",

volume = "244",

pages = "112--20",

journal = "TOXICOL LETT",

issn = "0378-4274",

publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations

AU - Steinritz, Dirk

AU - Striepling, Enno

AU - Rudolf, Klaus-Dieter

AU - Schröder-Kraft, Claudia

AU - Püschel, Klaus

AU - Hullard-Pulstinger, Andreas

AU - Koller, Marianne

AU - Thiermann, Horst

AU - Gandor, Felix

AU - Gawlik, Michael

AU - John, Harald

PY - 2016/2/26

Y1 - 2016/2/26

N2 - Sulfur mustard (SM) is a chemical warfare agent (CWA) that was first used in World War I and in several military conflicts afterwards. The threat by SM is still present even today due to remaining stockpiles, old and abandoned remainders all over the world as well as to its ease of synthesis. CWA are banned by the Chemical Weapons Convention (CWC) interdicting their development, production, transport, stockpiling and use and are subjected to controlled destruction. The present case report describes an accidental exposure of three workers that occurred during the destruction of SM. All exposed workers presented a characteristic SM-related clinical picture that started about 4h after exposure with erythema and feeling of tension of the skin at the upper part of the body. Later on, superficial blister and a burning phenomenon of the affected skin areas developed. Similar symptoms occurred in all three patients differing severity. One patient presented sustained skin affections at the gluteal region while another patient came up with affections of the axilla and genital region. Fortunately, full recovery was observed on day 56 after exposure except some little pigmentation changes that were evident even on day 154 in two of the patients. SM-exposure was verified for all three patients using bioanalytical GC MS and LC MS/MS based methods applied to urine and plasma. Urinary biotransformation products of the β-lyase pathway were detected until 5 days after poisoning whereas albumin-SM adducts could be found until day 29 underlining the beneficial role of adduct detection for post-exposure verification. In addition, we provide general recommendations for management and therapy in case of SM poisoning.

AB - Sulfur mustard (SM) is a chemical warfare agent (CWA) that was first used in World War I and in several military conflicts afterwards. The threat by SM is still present even today due to remaining stockpiles, old and abandoned remainders all over the world as well as to its ease of synthesis. CWA are banned by the Chemical Weapons Convention (CWC) interdicting their development, production, transport, stockpiling and use and are subjected to controlled destruction. The present case report describes an accidental exposure of three workers that occurred during the destruction of SM. All exposed workers presented a characteristic SM-related clinical picture that started about 4h after exposure with erythema and feeling of tension of the skin at the upper part of the body. Later on, superficial blister and a burning phenomenon of the affected skin areas developed. Similar symptoms occurred in all three patients differing severity. One patient presented sustained skin affections at the gluteal region while another patient came up with affections of the axilla and genital region. Fortunately, full recovery was observed on day 56 after exposure except some little pigmentation changes that were evident even on day 154 in two of the patients. SM-exposure was verified for all three patients using bioanalytical GC MS and LC MS/MS based methods applied to urine and plasma. Urinary biotransformation products of the β-lyase pathway were detected until 5 days after poisoning whereas albumin-SM adducts could be found until day 29 underlining the beneficial role of adduct detection for post-exposure verification. In addition, we provide general recommendations for management and therapy in case of SM poisoning.

U2 - 10.1016/j.toxlet.2015.08.1105

DO - 10.1016/j.toxlet.2015.08.1105

M3 - SCORING: Journal article

C2 - 26321678

VL - 244

SP - 112

EP - 120

JO - TOXICOL LETT

JF - TOXICOL LETT

SN - 0378-4274

ER -