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Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors

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Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors. / van der Giet, M; Jankowski, J; Schlüter, H; Zidek, W; Tepel, M.

in: J HYPERTENS, Jahrgang 16, Nr. 12 Pt 2, 12.1998, S. 1939-43.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

van der Giet, M, Jankowski, J, Schlüter, H, Zidek, W & Tepel, M 1998, 'Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors', J HYPERTENS, Jg. 16, Nr. 12 Pt 2, S. 1939-43.

APA

van der Giet, M., Jankowski, J., Schlüter, H., Zidek, W., & Tepel, M. (1998). Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors. J HYPERTENS, 16(12 Pt 2), 1939-43.

Vancouver

van der Giet M, Jankowski J, Schlüter H, Zidek W, Tepel M. Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors. J HYPERTENS. 1998 Dez;16(12 Pt 2):1939-43.

Bibtex

@article{2bf2d30bedb9473da4020940cbcc0f97,
title = "Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors",
abstract = "OBJECTIVE AND METHODS: The vasoactive properties of P1,P4-diadenosine tetraphosphate (Ap4A) were studied by measuring the effects of perfusion pressure of a rat isolated perfused kidney.RESULTS: The vasoconstrictive response to Ap4A was mediated to a large extent to a P2X receptor which could be shown by inhibition with pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium. The remaining vasoconstriction of Ap4A could be blocked by a 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1 receptor antagonist In raised tone preparation Ap4A evoked vasodilation when P2 receptors were blocked by suramin. The dilation was not mediated by a P2Y receptor as the effect could not be blocked by suramin.CONCLUSION: Ap4A induces vasoconstriction via A1 and P2X receptors and vasodilatation via an unidentified receptor which is not a P2Y receptor. Ap4A may play an important role in kidney perfusion and, thus, in blood-pressure control.",
keywords = "Adenosine Triphosphate, Adenosine-5'-(N-ethylcarboxamide), Animals, Dinucleoside Phosphates, In Vitro Techniques, Male, Perfusion, Pyridoxal Phosphate, Rats, Rats, Inbred WKY, Receptors, Purinergic, Receptors, Purinergic P1, Receptors, Purinergic P2, Renal Artery, Thionucleotides, Vasoconstrictor Agents, Vasodilator Agents, Xanthines, Journal Article",
author = "{van der Giet}, M and J Jankowski and H Schl{\"u}ter and W Zidek and M Tepel",
year = "1998",
month = dec,
language = "English",
volume = "16",
pages = "1939--43",
journal = "J HYPERTENS",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "12 Pt 2",

}

RIS

TY - JOUR

T1 - Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors

AU - van der Giet, M

AU - Jankowski, J

AU - Schlüter, H

AU - Zidek, W

AU - Tepel, M

PY - 1998/12

Y1 - 1998/12

N2 - OBJECTIVE AND METHODS: The vasoactive properties of P1,P4-diadenosine tetraphosphate (Ap4A) were studied by measuring the effects of perfusion pressure of a rat isolated perfused kidney.RESULTS: The vasoconstrictive response to Ap4A was mediated to a large extent to a P2X receptor which could be shown by inhibition with pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium. The remaining vasoconstriction of Ap4A could be blocked by a 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1 receptor antagonist In raised tone preparation Ap4A evoked vasodilation when P2 receptors were blocked by suramin. The dilation was not mediated by a P2Y receptor as the effect could not be blocked by suramin.CONCLUSION: Ap4A induces vasoconstriction via A1 and P2X receptors and vasodilatation via an unidentified receptor which is not a P2Y receptor. Ap4A may play an important role in kidney perfusion and, thus, in blood-pressure control.

AB - OBJECTIVE AND METHODS: The vasoactive properties of P1,P4-diadenosine tetraphosphate (Ap4A) were studied by measuring the effects of perfusion pressure of a rat isolated perfused kidney.RESULTS: The vasoconstrictive response to Ap4A was mediated to a large extent to a P2X receptor which could be shown by inhibition with pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium. The remaining vasoconstriction of Ap4A could be blocked by a 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1 receptor antagonist In raised tone preparation Ap4A evoked vasodilation when P2 receptors were blocked by suramin. The dilation was not mediated by a P2Y receptor as the effect could not be blocked by suramin.CONCLUSION: Ap4A induces vasoconstriction via A1 and P2X receptors and vasodilatation via an unidentified receptor which is not a P2Y receptor. Ap4A may play an important role in kidney perfusion and, thus, in blood-pressure control.

KW - Adenosine Triphosphate

KW - Adenosine-5'-(N-ethylcarboxamide)

KW - Animals

KW - Dinucleoside Phosphates

KW - In Vitro Techniques

KW - Male

KW - Perfusion

KW - Pyridoxal Phosphate

KW - Rats

KW - Rats, Inbred WKY

KW - Receptors, Purinergic

KW - Receptors, Purinergic P1

KW - Receptors, Purinergic P2

KW - Renal Artery

KW - Thionucleotides

KW - Vasoconstrictor Agents

KW - Vasodilator Agents

KW - Xanthines

KW - Journal Article

M3 - SCORING: Journal article

C2 - 9886880

VL - 16

SP - 1939

EP - 1943

JO - J HYPERTENS

JF - J HYPERTENS

SN - 0263-6352

IS - 12 Pt 2

ER -