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Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients

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Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients. / Porter, John B; Walter, Patrick B; Neumayr, Lynne D; Evans, Patricia; Bansal, Sukhvinder; Garbowski, Maciej; Weyhmiller, Marcela G; Harmatz, Paul R; Wood, John C; Miller, Jeffery L; Byrnes, Colleen; Weiss, Guenter; Seifert, Markus; Grosse, Regine; Grabowski, Dagmar; Schmidt, Angelica; Fischer, Roland; Nielsen, Peter; Niemeyer, Charlotte; Vichinsky, Elliott.

in: BRIT J HAEMATOL, Jahrgang 167, Nr. 5, 12.2014, S. 692-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Porter, JB, Walter, PB, Neumayr, LD, Evans, P, Bansal, S, Garbowski, M, Weyhmiller, MG, Harmatz, PR, Wood, JC, Miller, JL, Byrnes, C, Weiss, G, Seifert, M, Grosse, R, Grabowski, D, Schmidt, A, Fischer, R, Nielsen, P, Niemeyer, C & Vichinsky, E 2014, 'Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients', BRIT J HAEMATOL, Jg. 167, Nr. 5, S. 692-6. https://doi.org/10.1111/bjh.13081

APA

Porter, J. B., Walter, P. B., Neumayr, L. D., Evans, P., Bansal, S., Garbowski, M., Weyhmiller, M. G., Harmatz, P. R., Wood, J. C., Miller, J. L., Byrnes, C., Weiss, G., Seifert, M., Grosse, R., Grabowski, D., Schmidt, A., Fischer, R., Nielsen, P., Niemeyer, C., & Vichinsky, E. (2014). Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients. BRIT J HAEMATOL, 167(5), 692-6. https://doi.org/10.1111/bjh.13081

Vancouver

Porter JB, Walter PB, Neumayr LD, Evans P, Bansal S, Garbowski M et al. Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients. BRIT J HAEMATOL. 2014 Dez;167(5):692-6. https://doi.org/10.1111/bjh.13081

Bibtex

@article{02e1158512eb4ab2b7452b448f1def6a,
title = "Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients",
abstract = "In transfusional iron overload, extra-hepatic iron distribution differs, depending on the underlying condition. Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. Markers of iron metabolism (plasma NTBI, labile iron, hepcidin, transferrin, monocyte SLC40A1 [ferroportin]), erythropoiesis (growth differentiation factor 15, soluble transferrin receptor) and tissue hypoxia (erythropoietin) were compared in patients with Thalassaemia Major (TM), Sickle Cell Disease and Diamond-Blackfan Anaemia (DBA), with matched transfusion histories. The most striking differences between these conditions were relationships of NTBI to erythropoietic markers, leading us to propose three mechanisms of NTBI generation: iron overload (all), ineffective erythropoiesis (predominantly TM) and low transferrin-iron utilization (DBA).",
keywords = "Adolescent, Adult, Anemia, Diamond-Blackfan, Anemia, Sickle Cell, Biomarkers, Blood Proteins, Blood Transfusion, Erythropoiesis, Female, Humans, Iron, Iron Overload, Male, Thalassemia, Transferrin",
author = "Porter, {John B} and Walter, {Patrick B} and Neumayr, {Lynne D} and Patricia Evans and Sukhvinder Bansal and Maciej Garbowski and Weyhmiller, {Marcela G} and Harmatz, {Paul R} and Wood, {John C} and Miller, {Jeffery L} and Colleen Byrnes and Guenter Weiss and Markus Seifert and Regine Grosse and Dagmar Grabowski and Angelica Schmidt and Roland Fischer and Peter Nielsen and Charlotte Niemeyer and Elliott Vichinsky",
note = "{\textcopyright} 2014 John Wiley & Sons Ltd.",
year = "2014",
month = dec,
doi = "10.1111/bjh.13081",
language = "English",
volume = "167",
pages = "692--6",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients

AU - Porter, John B

AU - Walter, Patrick B

AU - Neumayr, Lynne D

AU - Evans, Patricia

AU - Bansal, Sukhvinder

AU - Garbowski, Maciej

AU - Weyhmiller, Marcela G

AU - Harmatz, Paul R

AU - Wood, John C

AU - Miller, Jeffery L

AU - Byrnes, Colleen

AU - Weiss, Guenter

AU - Seifert, Markus

AU - Grosse, Regine

AU - Grabowski, Dagmar

AU - Schmidt, Angelica

AU - Fischer, Roland

AU - Nielsen, Peter

AU - Niemeyer, Charlotte

AU - Vichinsky, Elliott

N1 - © 2014 John Wiley & Sons Ltd.

PY - 2014/12

Y1 - 2014/12

N2 - In transfusional iron overload, extra-hepatic iron distribution differs, depending on the underlying condition. Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. Markers of iron metabolism (plasma NTBI, labile iron, hepcidin, transferrin, monocyte SLC40A1 [ferroportin]), erythropoiesis (growth differentiation factor 15, soluble transferrin receptor) and tissue hypoxia (erythropoietin) were compared in patients with Thalassaemia Major (TM), Sickle Cell Disease and Diamond-Blackfan Anaemia (DBA), with matched transfusion histories. The most striking differences between these conditions were relationships of NTBI to erythropoietic markers, leading us to propose three mechanisms of NTBI generation: iron overload (all), ineffective erythropoiesis (predominantly TM) and low transferrin-iron utilization (DBA).

AB - In transfusional iron overload, extra-hepatic iron distribution differs, depending on the underlying condition. Relative mechanisms of plasma non-transferrin bound iron (NTBI) generation may account for these differences. Markers of iron metabolism (plasma NTBI, labile iron, hepcidin, transferrin, monocyte SLC40A1 [ferroportin]), erythropoiesis (growth differentiation factor 15, soluble transferrin receptor) and tissue hypoxia (erythropoietin) were compared in patients with Thalassaemia Major (TM), Sickle Cell Disease and Diamond-Blackfan Anaemia (DBA), with matched transfusion histories. The most striking differences between these conditions were relationships of NTBI to erythropoietic markers, leading us to propose three mechanisms of NTBI generation: iron overload (all), ineffective erythropoiesis (predominantly TM) and low transferrin-iron utilization (DBA).

KW - Adolescent

KW - Adult

KW - Anemia, Diamond-Blackfan

KW - Anemia, Sickle Cell

KW - Biomarkers

KW - Blood Proteins

KW - Blood Transfusion

KW - Erythropoiesis

KW - Female

KW - Humans

KW - Iron

KW - Iron Overload

KW - Male

KW - Thalassemia

KW - Transferrin

U2 - 10.1111/bjh.13081

DO - 10.1111/bjh.13081

M3 - SCORING: Journal article

C2 - 25209728

VL - 167

SP - 692

EP - 696

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 5

ER -