Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
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Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling. / Schöttelndreier, H; Potter, B V; Mayr, Georg W.; Guse, A H.
in: CELL SIGNAL, Jahrgang 13, Nr. 12, 12, 2001, S. 895-899.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
AU - Schöttelndreier, H
AU - Potter, B V
AU - Mayr, Georg W.
AU - Guse, A H
PY - 2001
Y1 - 2001
N2 - Contact of Jurkat T-lymphocytes with the extracellular matrix (ECM) protein laminin resulted in long-lasting alpha6beta1-integrin-mediated Ca(2+) signalling. Both Ca(2+) release from thapsigargin-sensitive Ca(2+) stores and capacitative Ca(2+) entry via Ca(2+) channels sensitive to SKF 96365 constitute important parts of this process. Inhibition of alpha6beta1-integrin-mediated Ca(2+) signalling by (1) the src kinase inhibitor PP2, (2) the PLC inhibitor U73122, and (3) the cyclic adenosine diphosphoribose (cADPR) antagonist 7-deaza-8-Br-cADPR indicate the involvement of src tyrosine kinases and the Ca(2+)-releasing second messengers D-myo-inositol 1,4,5-trisphosphate (InsP3) and cADPR.
AB - Contact of Jurkat T-lymphocytes with the extracellular matrix (ECM) protein laminin resulted in long-lasting alpha6beta1-integrin-mediated Ca(2+) signalling. Both Ca(2+) release from thapsigargin-sensitive Ca(2+) stores and capacitative Ca(2+) entry via Ca(2+) channels sensitive to SKF 96365 constitute important parts of this process. Inhibition of alpha6beta1-integrin-mediated Ca(2+) signalling by (1) the src kinase inhibitor PP2, (2) the PLC inhibitor U73122, and (3) the cyclic adenosine diphosphoribose (cADPR) antagonist 7-deaza-8-Br-cADPR indicate the involvement of src tyrosine kinases and the Ca(2+)-releasing second messengers D-myo-inositol 1,4,5-trisphosphate (InsP3) and cADPR.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 895
EP - 899
JO - CELL SIGNAL
JF - CELL SIGNAL
SN - 0898-6568
IS - 12
M1 - 12
ER -