PortalPublikationenMechanisms and roles of podosomes and invadopodia

Mechanisms and roles of podosomes and invadopodia

Standard

Mechanisms and roles of podosomes and invadopodia. / Linder, Stefan; Cervero, Pasquale; Eddy, Robert; Condeelis, John.

in: NAT REV MOL CELL BIO, Jahrgang 24, 2023, S. 86–106.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Linder, S, Cervero, P, Eddy, R & Condeelis, J 2023, 'Mechanisms and roles of podosomes and invadopodia', NAT REV MOL CELL BIO, Jg. 24, S. 86–106. https://doi.org/10.1038/s41580-022-00530-6

APA

Linder, S., Cervero, P., Eddy, R., & Condeelis, J. (2023). Mechanisms and roles of podosomes and invadopodia. NAT REV MOL CELL BIO, 24, 86–106. https://doi.org/10.1038/s41580-022-00530-6

Vancouver

Linder S, Cervero P, Eddy R, Condeelis J. Mechanisms and roles of podosomes and invadopodia. NAT REV MOL CELL BIO. 2023;24:86–106. https://doi.org/10.1038/s41580-022-00530-6

Bibtex

@article{6fac637e3bef4ab8b833ee6c6e010547,
title = "Mechanisms and roles of podosomes and invadopodia",
abstract = "Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in both physiological and pathological scenarios such as immune surveillance or cancer metastasis. Podosomes and invadopodia, collectively called {\textquoteleft}invadosomes{\textquoteright}, are actin-based structures that drive the proteolytic invasion of cells, by forming highly regulated platforms for the localized release of lytic enzymes that degrade the matrix. Recent advances in high-resolution microscopy techniques, in vivo imaging and high-throughput analyses have led to considerable progress in understanding mechanisms of invadosomes, revealing the intricate inner architecture of these structures, as well as their growing repertoire of functions that extends well beyond matrix degradation. In this Review, we discuss the known functions, architecture and regulatory mechanisms of podosomes and invadopodia. In particular, we describe the molecular mechanisms of localized actin turnover and microtubule-based cargo delivery, with a special focus on matrix-lytic enzymes that enable proteolytic invasion. Finally, we point out topics that should become important in the invadosome field in the future.",
author = "Stefan Linder and Pasquale Cervero and Robert Eddy and John Condeelis",
year = "2023",
doi = "10.1038/s41580-022-00530-6",
language = "English",
volume = "24",
pages = "86–106",
journal = "NAT REV MOL CELL BIO",
issn = "1471-0072",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Mechanisms and roles of podosomes and invadopodia

AU - Linder, Stefan

AU - Cervero, Pasquale

AU - Eddy, Robert

AU - Condeelis, John

PY - 2023

Y1 - 2023

N2 - Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in both physiological and pathological scenarios such as immune surveillance or cancer metastasis. Podosomes and invadopodia, collectively called ‘invadosomes’, are actin-based structures that drive the proteolytic invasion of cells, by forming highly regulated platforms for the localized release of lytic enzymes that degrade the matrix. Recent advances in high-resolution microscopy techniques, in vivo imaging and high-throughput analyses have led to considerable progress in understanding mechanisms of invadosomes, revealing the intricate inner architecture of these structures, as well as their growing repertoire of functions that extends well beyond matrix degradation. In this Review, we discuss the known functions, architecture and regulatory mechanisms of podosomes and invadopodia. In particular, we describe the molecular mechanisms of localized actin turnover and microtubule-based cargo delivery, with a special focus on matrix-lytic enzymes that enable proteolytic invasion. Finally, we point out topics that should become important in the invadosome field in the future.

AB - Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in both physiological and pathological scenarios such as immune surveillance or cancer metastasis. Podosomes and invadopodia, collectively called ‘invadosomes’, are actin-based structures that drive the proteolytic invasion of cells, by forming highly regulated platforms for the localized release of lytic enzymes that degrade the matrix. Recent advances in high-resolution microscopy techniques, in vivo imaging and high-throughput analyses have led to considerable progress in understanding mechanisms of invadosomes, revealing the intricate inner architecture of these structures, as well as their growing repertoire of functions that extends well beyond matrix degradation. In this Review, we discuss the known functions, architecture and regulatory mechanisms of podosomes and invadopodia. In particular, we describe the molecular mechanisms of localized actin turnover and microtubule-based cargo delivery, with a special focus on matrix-lytic enzymes that enable proteolytic invasion. Finally, we point out topics that should become important in the invadosome field in the future.

U2 - 10.1038/s41580-022-00530-6

DO - 10.1038/s41580-022-00530-6

M3 - SCORING: Review article

VL - 24

SP - 86

EP - 106

JO - NAT REV MOL CELL BIO

JF - NAT REV MOL CELL BIO

SN - 1471-0072

ER -