Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors

Andreas H Guse; Diana C Gil Montoya; Björn-Philipp Diercks

doi:10.1016/j.pharmthera.2021.107804

Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors

Standard

Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. / Guse, Andreas H; Gil Montoya, Diana C; Diercks, Björn-Philipp.

in: PHARMACOL THERAPEUT, Jahrgang 223, 07.2021, S. 107804.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Guse, AH, Gil Montoya, DC & Diercks, B-P 2021, 'Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors', PHARMACOL THERAPEUT, Jg. 223, S. 107804. https://doi.org/10.1016/j.pharmthera.2021.107804

APA

Guse, A. H., Gil Montoya, D. C., & Diercks, B-P. (2021). Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. PHARMACOL THERAPEUT, 223, 107804. https://doi.org/10.1016/j.pharmthera.2021.107804

Vancouver

Guse AH, Gil Montoya DC, Diercks B-P. Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. PHARMACOL THERAPEUT. 2021 Jul;223:107804. https://doi.org/10.1016/j.pharmthera.2021.107804

Bibtex

@article{f5af1a70ff5f46ada08fe24f40bf6ad1,

title = "Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors",

abstract = "With the discovery of local Ca2+ signals in the 1990s the concept of 'elementary Ca2+ signals' and 'fundamental Ca2+ signals' was developed. While 'elementary Ca2+signals' relate to optical signals gained by activity of small clusters of Ca2+channels, 'fundamental signals' describe such optical signals that arise from opening of single Ca2+channels. In this review, we discuss (i) concepts of local Ca2+ signals and Ca2+ microdomains, (ii) molecular mechanisms underlying Ca2+ microdomains, (iii) functions of Ca2+ microdomains, and (iv) mathematical modelling of Ca2+ microdomains. We focus on Ca2+ microdomains produced by ORAI channels, D-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. In summary, research on local Ca2+ signals in different cell models aims to better understand how cells use the Ca2+ toolkit to produce Ca2+ microdomains as relevant signals for specific cellular responses, but also how local Ca2+ signals as building blocks merge into global Ca2+ signaling.",

author = "Guse, {Andreas H} and {Gil Montoya}, {Diana C} and Bj{\"o}rn-Philipp Diercks",

note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",

year = "2021",

month = jul,

doi = "10.1016/j.pharmthera.2021.107804",

language = "English",

volume = "223",

pages = "107804",

journal = "PHARMACOL THERAPEUT",

issn = "0163-7258",

publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors

AU - Guse, Andreas H

AU - Gil Montoya, Diana C

AU - Diercks, Björn-Philipp

PY - 2021/7

Y1 - 2021/7

N2 - With the discovery of local Ca2+ signals in the 1990s the concept of 'elementary Ca2+ signals' and 'fundamental Ca2+ signals' was developed. While 'elementary Ca2+signals' relate to optical signals gained by activity of small clusters of Ca2+channels, 'fundamental signals' describe such optical signals that arise from opening of single Ca2+channels. In this review, we discuss (i) concepts of local Ca2+ signals and Ca2+ microdomains, (ii) molecular mechanisms underlying Ca2+ microdomains, (iii) functions of Ca2+ microdomains, and (iv) mathematical modelling of Ca2+ microdomains. We focus on Ca2+ microdomains produced by ORAI channels, D-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. In summary, research on local Ca2+ signals in different cell models aims to better understand how cells use the Ca2+ toolkit to produce Ca2+ microdomains as relevant signals for specific cellular responses, but also how local Ca2+ signals as building blocks merge into global Ca2+ signaling.

AB - With the discovery of local Ca2+ signals in the 1990s the concept of 'elementary Ca2+ signals' and 'fundamental Ca2+ signals' was developed. While 'elementary Ca2+signals' relate to optical signals gained by activity of small clusters of Ca2+channels, 'fundamental signals' describe such optical signals that arise from opening of single Ca2+channels. In this review, we discuss (i) concepts of local Ca2+ signals and Ca2+ microdomains, (ii) molecular mechanisms underlying Ca2+ microdomains, (iii) functions of Ca2+ microdomains, and (iv) mathematical modelling of Ca2+ microdomains. We focus on Ca2+ microdomains produced by ORAI channels, D-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors. In summary, research on local Ca2+ signals in different cell models aims to better understand how cells use the Ca2+ toolkit to produce Ca2+ microdomains as relevant signals for specific cellular responses, but also how local Ca2+ signals as building blocks merge into global Ca2+ signaling.

U2 - 10.1016/j.pharmthera.2021.107804

DO - 10.1016/j.pharmthera.2021.107804

M3 - SCORING: Review article

C2 - 33465399

VL - 223

SP - 107804

JO - PHARMACOL THERAPEUT

JF - PHARMACOL THERAPEUT

SN - 0163-7258

ER -