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Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany

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Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany. / Roedl, Kevin; Jarczak, Dominik; Thasler, Liina; Bachmann, Martin; Schulte, Frank; Bein, Berthold; Weber, Christian Friedrich; Schäfer, Ulrich; Veit, Carsten; Hauber, Hans-Peter; Kopp, Sebastian; Sydow, Karsten; de Weerth, Andreas; Bota, Marc; Schreiber, Rüdiger; Detsch, Oliver; Rogmann, Jan-Peer; Frings, Daniel; Sensen, Barbara; Burdelski, Christoph; Boenisch, Olaf; Nierhaus, Axel; de Heer, Geraldine; Kluge, Stefan.

in: AUST CRIT CARE, Jahrgang 34, Nr. 2, 03.2021, S. 167-175.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Roedl, K, Jarczak, D, Thasler, L, Bachmann, M, Schulte, F, Bein, B, Weber, CF, Schäfer, U, Veit, C, Hauber, H-P, Kopp, S, Sydow, K, de Weerth, A, Bota, M, Schreiber, R, Detsch, O, Rogmann, J-P, Frings, D, Sensen, B, Burdelski, C, Boenisch, O, Nierhaus, A, de Heer, G & Kluge, S 2021, 'Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany', AUST CRIT CARE, Jg. 34, Nr. 2, S. 167-175. https://doi.org/10.1016/j.aucc.2020.10.009

APA

Roedl, K., Jarczak, D., Thasler, L., Bachmann, M., Schulte, F., Bein, B., Weber, C. F., Schäfer, U., Veit, C., Hauber, H-P., Kopp, S., Sydow, K., de Weerth, A., Bota, M., Schreiber, R., Detsch, O., Rogmann, J-P., Frings, D., Sensen, B., ... Kluge, S. (2021). Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany. AUST CRIT CARE, 34(2), 167-175. https://doi.org/10.1016/j.aucc.2020.10.009

Vancouver

Roedl K, Jarczak D, Thasler L, Bachmann M, Schulte F, Bein B et al. Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany. AUST CRIT CARE. 2021 Mär;34(2):167-175. https://doi.org/10.1016/j.aucc.2020.10.009

Bibtex

@article{d71c971f945c4123af1a3bfbedafa5be,
title = "Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany",
abstract = "BACKGROUND: There are large uncertainties with regard to the outcome of patients with coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50-97%) was proposed by some groups, leading to considerable uncertainties with regard to outcomes of critically ill patients with COVID-19.OBJECTIVES: The aim was to investigate the characteristics and outcomes of critically ill patients with COVID-19 requiring intensive care unit (ICU) admission and MV.METHODS: A multicentre retrospective observational cohort study at 15 hospitals in Hamburg, Germany, was performed. Critically ill adult patients with COVID-19 who completed their ICU stay between February and June 2020 were included. Patient demographics, severity of illness, and ICU course were retrospectively evaluated.RESULTS: A total of 223 critically ill patients with COVID-19 were included. The majority, 73% (n = 163), were men; the median age was 69 (interquartile range = 58-77.5) years, with 68% (n = 151) patients having at least one chronic medical condition. Their Sequential Organ Failure Assessment score was a median of 5 (3-9) points on admission. Overall, 167 (75%) patients needed MV. Noninvasive ventilation and high-flow nasal cannula were used in 31 (14%) and 26 (12%) patients, respectively. Subsequent MV, due to noninvasive ventilation/high-flow nasal cannula therapy failure, was necessary in 46 (81%) patients. Renal replacement therapy was initiated in 33% (n = 72) of patients, and owing to severe respiratory failure, extracorporeal membrane oxygenation was necessary in 9% (n = 20) of patients. Experimental antiviral therapy was used in 9% (n = 21) of patients. Complications during the ICU stay were as follows: septic shock (40%, n = 90), heart failure (8%, n = 17), and pulmonary embolism (6%, n = 14). The length of ICU stay was a median of 13 days (5-24), and the duration of MV was 15 days (8-25). The ICU mortality was 35% (n = 78) and 44% (n = 74) among mechanically ventilated patients.CONCLUSION: In this multicentre observational study of 223 critically ill patients with COVID-19, the survival to ICU discharge was 65%, and it was 56% among patients requiring MV. Patients showed high rate of septic complications during their ICU stay.",
author = "Kevin Roedl and Dominik Jarczak and Liina Thasler and Martin Bachmann and Frank Schulte and Berthold Bein and Weber, {Christian Friedrich} and Ulrich Sch{\"a}fer and Carsten Veit and Hans-Peter Hauber and Sebastian Kopp and Karsten Sydow and {de Weerth}, Andreas and Marc Bota and R{\"u}diger Schreiber and Oliver Detsch and Jan-Peer Rogmann and Daniel Frings and Barbara Sensen and Christoph Burdelski and Olaf Boenisch and Axel Nierhaus and {de Heer}, Geraldine and Stefan Kluge",
note = "Copyright {\textcopyright} 2020 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.aucc.2020.10.009",
language = "English",
volume = "34",
pages = "167--175",
journal = "AUST CRIT CARE",
issn = "1036-7314",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany

AU - Roedl, Kevin

AU - Jarczak, Dominik

AU - Thasler, Liina

AU - Bachmann, Martin

AU - Schulte, Frank

AU - Bein, Berthold

AU - Weber, Christian Friedrich

AU - Schäfer, Ulrich

AU - Veit, Carsten

AU - Hauber, Hans-Peter

AU - Kopp, Sebastian

AU - Sydow, Karsten

AU - de Weerth, Andreas

AU - Bota, Marc

AU - Schreiber, Rüdiger

AU - Detsch, Oliver

AU - Rogmann, Jan-Peer

AU - Frings, Daniel

AU - Sensen, Barbara

AU - Burdelski, Christoph

AU - Boenisch, Olaf

AU - Nierhaus, Axel

AU - de Heer, Geraldine

AU - Kluge, Stefan

N1 - Copyright © 2020 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: There are large uncertainties with regard to the outcome of patients with coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50-97%) was proposed by some groups, leading to considerable uncertainties with regard to outcomes of critically ill patients with COVID-19.OBJECTIVES: The aim was to investigate the characteristics and outcomes of critically ill patients with COVID-19 requiring intensive care unit (ICU) admission and MV.METHODS: A multicentre retrospective observational cohort study at 15 hospitals in Hamburg, Germany, was performed. Critically ill adult patients with COVID-19 who completed their ICU stay between February and June 2020 were included. Patient demographics, severity of illness, and ICU course were retrospectively evaluated.RESULTS: A total of 223 critically ill patients with COVID-19 were included. The majority, 73% (n = 163), were men; the median age was 69 (interquartile range = 58-77.5) years, with 68% (n = 151) patients having at least one chronic medical condition. Their Sequential Organ Failure Assessment score was a median of 5 (3-9) points on admission. Overall, 167 (75%) patients needed MV. Noninvasive ventilation and high-flow nasal cannula were used in 31 (14%) and 26 (12%) patients, respectively. Subsequent MV, due to noninvasive ventilation/high-flow nasal cannula therapy failure, was necessary in 46 (81%) patients. Renal replacement therapy was initiated in 33% (n = 72) of patients, and owing to severe respiratory failure, extracorporeal membrane oxygenation was necessary in 9% (n = 20) of patients. Experimental antiviral therapy was used in 9% (n = 21) of patients. Complications during the ICU stay were as follows: septic shock (40%, n = 90), heart failure (8%, n = 17), and pulmonary embolism (6%, n = 14). The length of ICU stay was a median of 13 days (5-24), and the duration of MV was 15 days (8-25). The ICU mortality was 35% (n = 78) and 44% (n = 74) among mechanically ventilated patients.CONCLUSION: In this multicentre observational study of 223 critically ill patients with COVID-19, the survival to ICU discharge was 65%, and it was 56% among patients requiring MV. Patients showed high rate of septic complications during their ICU stay.

AB - BACKGROUND: There are large uncertainties with regard to the outcome of patients with coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50-97%) was proposed by some groups, leading to considerable uncertainties with regard to outcomes of critically ill patients with COVID-19.OBJECTIVES: The aim was to investigate the characteristics and outcomes of critically ill patients with COVID-19 requiring intensive care unit (ICU) admission and MV.METHODS: A multicentre retrospective observational cohort study at 15 hospitals in Hamburg, Germany, was performed. Critically ill adult patients with COVID-19 who completed their ICU stay between February and June 2020 were included. Patient demographics, severity of illness, and ICU course were retrospectively evaluated.RESULTS: A total of 223 critically ill patients with COVID-19 were included. The majority, 73% (n = 163), were men; the median age was 69 (interquartile range = 58-77.5) years, with 68% (n = 151) patients having at least one chronic medical condition. Their Sequential Organ Failure Assessment score was a median of 5 (3-9) points on admission. Overall, 167 (75%) patients needed MV. Noninvasive ventilation and high-flow nasal cannula were used in 31 (14%) and 26 (12%) patients, respectively. Subsequent MV, due to noninvasive ventilation/high-flow nasal cannula therapy failure, was necessary in 46 (81%) patients. Renal replacement therapy was initiated in 33% (n = 72) of patients, and owing to severe respiratory failure, extracorporeal membrane oxygenation was necessary in 9% (n = 20) of patients. Experimental antiviral therapy was used in 9% (n = 21) of patients. Complications during the ICU stay were as follows: septic shock (40%, n = 90), heart failure (8%, n = 17), and pulmonary embolism (6%, n = 14). The length of ICU stay was a median of 13 days (5-24), and the duration of MV was 15 days (8-25). The ICU mortality was 35% (n = 78) and 44% (n = 74) among mechanically ventilated patients.CONCLUSION: In this multicentre observational study of 223 critically ill patients with COVID-19, the survival to ICU discharge was 65%, and it was 56% among patients requiring MV. Patients showed high rate of septic complications during their ICU stay.

U2 - 10.1016/j.aucc.2020.10.009

DO - 10.1016/j.aucc.2020.10.009

M3 - SCORING: Journal article

C2 - 33250401

VL - 34

SP - 167

EP - 175

JO - AUST CRIT CARE

JF - AUST CRIT CARE

SN - 1036-7314

IS - 2

ER -