Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability

TY - JOUR

T1 - Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability

AU - Panova-Noeva, Marina

AU - Arnold, Natalie

AU - Hermanns, M Iris

AU - Prochaska, Jürgen H

AU - Schulz, Andreas

AU - Spronk, Henri M

AU - Binder, Harald

AU - Pfeiffer, Norbert

AU - Beutel, Manfred

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Lotz, Johannes

AU - Münzel, Thomas

AU - Lackner, Karl J

AU - Ten Cate, Hugo

AU - Wild, Philipp S

PY - 2017/1/6

Y1 - 2017/1/6

N2 - Vessel wall stiffening is an important clinical parameter, but it is unknown whether platelets, key elements in the pathogenesis of arterial thrombosis, are associated with arterial stiffness. The present studies sought to determine whether mean platelet volume (MPV), a potential marker of platelet activation, is linked to vascular elasticity as assessed by the augmentation index (AIx), in 15,010 individuals from the population-based Gutenberg Health Study. Multivariable analysis showed that MPV in both males (β 0.776; 95thCI [0.250;1.16]; p = 0.0024) and females (β 0.881[0.328;1.43]; p = 0.0018) is strongly associated with AIx. Individuals with MPV and AIx above the sex-specific medians had worse survival. Association analysis between MPV-related genetic variants and arterial stiffness identified four genetic variants in males and one in females related with AIx. Cox regression analysis for mortality identified one of these joint genetic variants close to ring finger protein 145 gene (RNF145, rs10076782) linked with increased mortality (hazard ratio 2.02; 95thCI [1.35;3.02]; p = 0.00061). Thus, these population-based data demonstrate a close relation between platelet volume as a potential marker of platelet activation and arterial stiffness in both sexes. Further research is warranted to further elucidate the mechanisms underlying larger platelets' role in arterial stiffening including the role of shared common genetics.

AB - Vessel wall stiffening is an important clinical parameter, but it is unknown whether platelets, key elements in the pathogenesis of arterial thrombosis, are associated with arterial stiffness. The present studies sought to determine whether mean platelet volume (MPV), a potential marker of platelet activation, is linked to vascular elasticity as assessed by the augmentation index (AIx), in 15,010 individuals from the population-based Gutenberg Health Study. Multivariable analysis showed that MPV in both males (β 0.776; 95thCI [0.250;1.16]; p = 0.0024) and females (β 0.881[0.328;1.43]; p = 0.0018) is strongly associated with AIx. Individuals with MPV and AIx above the sex-specific medians had worse survival. Association analysis between MPV-related genetic variants and arterial stiffness identified four genetic variants in males and one in females related with AIx. Cox regression analysis for mortality identified one of these joint genetic variants close to ring finger protein 145 gene (RNF145, rs10076782) linked with increased mortality (hazard ratio 2.02; 95thCI [1.35;3.02]; p = 0.00061). Thus, these population-based data demonstrate a close relation between platelet volume as a potential marker of platelet activation and arterial stiffness in both sexes. Further research is warranted to further elucidate the mechanisms underlying larger platelets' role in arterial stiffening including the role of shared common genetics.

KW - Biomarkers

KW - Cardiovascular Diseases/epidemiology

KW - Elasticity

KW - Female

KW - Genetic Variation

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Mean Platelet Volume

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Sex Factors

KW - Vascular Stiffness

U2 - 10.1038/srep40229

DO - 10.1038/srep40229

M3 - SCORING: Journal article

C2 - 28059166

VL - 7

SP - 40229

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -