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MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

Standard

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties. / Dietl, Sebastian; Schwinn, Stefanie; Dietl, Susanne; Riedel, Simone; Deinlein, Frank; Rutkowski, Stefan; von Bueren, Andre O; Krauss, Jürgen; Schweitzer, Tilmann; Vince, Giles H; Picard, Daniel; Eyrich, Matthias; Rosenwald, Andreas; Ramaswamy, Vijay; Taylor, Michael D; Remke, Marc; Monoranu, Camelia M; Beilhack, Andreas; Schlegel, Paul G; Wölfl, Matthias.

in: BMC CANCER, Jahrgang 16, Nr. 1, 2016, S. 115.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dietl, S, Schwinn, S, Dietl, S, Riedel, S, Deinlein, F, Rutkowski, S, von Bueren, AO, Krauss, J, Schweitzer, T, Vince, GH, Picard, D, Eyrich, M, Rosenwald, A, Ramaswamy, V, Taylor, MD, Remke, M, Monoranu, CM, Beilhack, A, Schlegel, PG & Wölfl, M 2016, 'MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties', BMC CANCER, Jg. 16, Nr. 1, S. 115. https://doi.org/10.1186/s12885-016-2170-z

APA

Dietl, S., Schwinn, S., Dietl, S., Riedel, S., Deinlein, F., Rutkowski, S., von Bueren, A. O., Krauss, J., Schweitzer, T., Vince, G. H., Picard, D., Eyrich, M., Rosenwald, A., Ramaswamy, V., Taylor, M. D., Remke, M., Monoranu, C. M., Beilhack, A., Schlegel, P. G., & Wölfl, M. (2016). MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties. BMC CANCER, 16(1), 115. https://doi.org/10.1186/s12885-016-2170-z

Vancouver

Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S et al. MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties. BMC CANCER. 2016;16(1):115. https://doi.org/10.1186/s12885-016-2170-z

Bibtex

@article{373fce49a97c4bc5bbe5714e9c911020,
title = "MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties",
abstract = "BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children and can be divided in different molecular subgroups. Patients whose tumor is classified as a Group 3 tumor have a dismal prognosis. However only very few tumor models are available for this subgroup.METHODS: We established a robust orthotopic xenograft model with a cell line derived from the malignant pleural effusions of a child suffering from a Group 3 medulloblastoma.RESULTS: Besides classical characteristics of this tumor subgroup, the cells display cancer stem cell characteristics including neurosphere formation, multilineage differentiation, CD133/CD15 expression, high ALDH-activity and high tumorigenicity in immunocompromised mice with xenografts exactly recapitulating the original tumor architecture.CONCLUSIONS: This model using unmanipulated, human medulloblastoma cells will enable translational research, specifically focused on Group 3 medulloblastoma.",
author = "Sebastian Dietl and Stefanie Schwinn and Susanne Dietl and Simone Riedel and Frank Deinlein and Stefan Rutkowski and {von Bueren}, {Andre O} and J{\"u}rgen Krauss and Tilmann Schweitzer and Vince, {Giles H} and Daniel Picard and Matthias Eyrich and Andreas Rosenwald and Vijay Ramaswamy and Taylor, {Michael D} and Marc Remke and Monoranu, {Camelia M} and Andreas Beilhack and Schlegel, {Paul G} and Matthias W{\"o}lfl",
year = "2016",
doi = "10.1186/s12885-016-2170-z",
language = "English",
volume = "16",
pages = "115",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties

AU - Dietl, Sebastian

AU - Schwinn, Stefanie

AU - Dietl, Susanne

AU - Riedel, Simone

AU - Deinlein, Frank

AU - Rutkowski, Stefan

AU - von Bueren, Andre O

AU - Krauss, Jürgen

AU - Schweitzer, Tilmann

AU - Vince, Giles H

AU - Picard, Daniel

AU - Eyrich, Matthias

AU - Rosenwald, Andreas

AU - Ramaswamy, Vijay

AU - Taylor, Michael D

AU - Remke, Marc

AU - Monoranu, Camelia M

AU - Beilhack, Andreas

AU - Schlegel, Paul G

AU - Wölfl, Matthias

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children and can be divided in different molecular subgroups. Patients whose tumor is classified as a Group 3 tumor have a dismal prognosis. However only very few tumor models are available for this subgroup.METHODS: We established a robust orthotopic xenograft model with a cell line derived from the malignant pleural effusions of a child suffering from a Group 3 medulloblastoma.RESULTS: Besides classical characteristics of this tumor subgroup, the cells display cancer stem cell characteristics including neurosphere formation, multilineage differentiation, CD133/CD15 expression, high ALDH-activity and high tumorigenicity in immunocompromised mice with xenografts exactly recapitulating the original tumor architecture.CONCLUSIONS: This model using unmanipulated, human medulloblastoma cells will enable translational research, specifically focused on Group 3 medulloblastoma.

AB - BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children and can be divided in different molecular subgroups. Patients whose tumor is classified as a Group 3 tumor have a dismal prognosis. However only very few tumor models are available for this subgroup.METHODS: We established a robust orthotopic xenograft model with a cell line derived from the malignant pleural effusions of a child suffering from a Group 3 medulloblastoma.RESULTS: Besides classical characteristics of this tumor subgroup, the cells display cancer stem cell characteristics including neurosphere formation, multilineage differentiation, CD133/CD15 expression, high ALDH-activity and high tumorigenicity in immunocompromised mice with xenografts exactly recapitulating the original tumor architecture.CONCLUSIONS: This model using unmanipulated, human medulloblastoma cells will enable translational research, specifically focused on Group 3 medulloblastoma.

U2 - 10.1186/s12885-016-2170-z

DO - 10.1186/s12885-016-2170-z

M3 - SCORING: Journal article

C2 - 26883117

VL - 16

SP - 115

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

IS - 1

ER -