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Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function?

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Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function? / Lopez-Rojas, Jeffrey; Kreutz, Michael R .

in: NEUROSCI BIOBEHAV R, Jahrgang 64, 05.2016, S. 167-74.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lopez-Rojas, J & Kreutz, MR 2016, 'Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function?', NEUROSCI BIOBEHAV R, Jg. 64, S. 167-74. https://doi.org/10.1016/j.neubiorev.2016.02.021

APA

Lopez-Rojas, J., & Kreutz, M. R. (2016). Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function? NEUROSCI BIOBEHAV R, 64, 167-74. https://doi.org/10.1016/j.neubiorev.2016.02.021

Vancouver

Lopez-Rojas J, Kreutz MR. Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function? NEUROSCI BIOBEHAV R. 2016 Mai;64:167-74. https://doi.org/10.1016/j.neubiorev.2016.02.021

Bibtex

@article{32c154a76c184aa8b24c6ddee45abf4d,
title = "Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function?",
abstract = "The dentate gyrus is the main entrance of highly processed information to the hippocampus which derives from associative cortices and it is one of the few privileged areas in the brain where adult neurogenesis occurs. This creates the unique situation that neurons of diverse maturation stages are part of one neuronal network at any given point in life. While recently adult-born cells have a low induction threshold for long-term potentiation several studies suggest that following maturation granule cells are poorly excitable and they exhibit reduced Hebbian synaptic plasticity to an extent that it was even suggested that they functionally retire. Here, we review the functional properties of mature granule cells and discuss how plasticity of intrinsic excitability and alterations in excitation-inhibition balance might impact on their role in hippocampal information processing.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Jeffrey Lopez-Rojas and Kreutz, {Michael R}",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2016",
month = may,
doi = "10.1016/j.neubiorev.2016.02.021",
language = "English",
volume = "64",
pages = "167--74",
journal = "NEUROSCI BIOBEHAV R",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Mature granule cells of the dentate gyrus--Passive bystanders or principal performers in hippocampal function?

AU - Lopez-Rojas, Jeffrey

AU - Kreutz, Michael R

N1 - Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2016/5

Y1 - 2016/5

N2 - The dentate gyrus is the main entrance of highly processed information to the hippocampus which derives from associative cortices and it is one of the few privileged areas in the brain where adult neurogenesis occurs. This creates the unique situation that neurons of diverse maturation stages are part of one neuronal network at any given point in life. While recently adult-born cells have a low induction threshold for long-term potentiation several studies suggest that following maturation granule cells are poorly excitable and they exhibit reduced Hebbian synaptic plasticity to an extent that it was even suggested that they functionally retire. Here, we review the functional properties of mature granule cells and discuss how plasticity of intrinsic excitability and alterations in excitation-inhibition balance might impact on their role in hippocampal information processing.

AB - The dentate gyrus is the main entrance of highly processed information to the hippocampus which derives from associative cortices and it is one of the few privileged areas in the brain where adult neurogenesis occurs. This creates the unique situation that neurons of diverse maturation stages are part of one neuronal network at any given point in life. While recently adult-born cells have a low induction threshold for long-term potentiation several studies suggest that following maturation granule cells are poorly excitable and they exhibit reduced Hebbian synaptic plasticity to an extent that it was even suggested that they functionally retire. Here, we review the functional properties of mature granule cells and discuss how plasticity of intrinsic excitability and alterations in excitation-inhibition balance might impact on their role in hippocampal information processing.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.neubiorev.2016.02.021

DO - 10.1016/j.neubiorev.2016.02.021

M3 - SCORING: Journal article

C2 - 26949226

VL - 64

SP - 167

EP - 174

JO - NEUROSCI BIOBEHAV R

JF - NEUROSCI BIOBEHAV R

SN - 0149-7634

ER -