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Maternal outcomes and risk factors for COVID-19 severity among pregnant women

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Maternal outcomes and risk factors for COVID-19 severity among pregnant women. / Vouga, Manon; Favre, Guillaume; Martinez-Perez, Oscar; Pomar, Leo; Acebal, Laura Forcen; Abascal-Saiz, Alejandra; Hernandez, Maria Rosa Vila; Hcini, Najeh; Lambert, Véronique; Carles, Gabriel; Sichitiu, Joanna; Salomon, Laurent; Stirnemann, Julien; Ville, Yves; de Tejada, Begoña Martinez; Goncé, Anna; Hawkins-Villarreal, Ameth; Castillo, Karen; Solsona, Eduard Gratacos; Trigo, Lucas; Cleary, Brian; Geary, Michael; Bartels, Helena; Al-Kharouf, Feras; Malone, Fergal; Higgins, Mary; Keating, Niamh; Knowles, Susan; Poncelet, Christophe; Ribeiro-do-Valle, Carolina Carvalho; Surita, Fernanda; Dantas-Silva, Amanda; Borrelli, Carolina; Luz, Adriana Gomes; Fuenzalida, Javiera; Carvajal, Jorge; Canales, Manuel Guerra; Hernandez, Olivia; Grechukhina, Olga; Ko, Albert I; Reddy, Uma; Figueiredo, Rita; Moucho, Marina; Pinto, Pedro Viana; De Luca, Carmen; De Santis, Marco; de Campos, Diogo Ayres; Martins, Inês; Garabedian, Charles; Subtil, Damien; Bohrer, Betania; Da Rocha Oppermann, Maria Lucia; Wender, Maria Celeste Osorio; Schuler-Faccini, Lavinia; Sanseverino, Maria Teresa Vieira; Giugliani, Camila; Friedrich, Luciana; Scherer, Mariana Horn; Mottet, Nicolas; Ducarme, Guillaume; Pelerin, Helene; Moreau, Chloe; Breton, Bénédicte; Quibel, Thibaud; Rozenberg, Patrick; Giannoni, Eric; Granado, Cristina; Monod, Cécile; Mueller, Doris; Hoesli, Irene; Bassler, Dirk; Heldstab, Sandra; Kölble, Nicole Ochsenbein; Sentilhes, Loïc; Charvet, Melissa; Deprest, Jan; Richter, Jute; Van der Veeken, Lennart; Eggel-Hort, Béatrice; Plantefeve, Gaetan; Derouich, Mohamed; Calvache, Albaro José Nieto; Lopez-Giron, Maria Camila; Burgos-Luna, Juan Manuel; Escobar-Vidarte, Maria Fernanda; Hecher, Kurt; Tallarek, Ann-Christin; Hadar, Eran; Haratz, Karina Krajden; Amikam, Uri; Malinger, Gustavo; Maymon, Ron; Yogev, Yariv; Schäffer, Leonhard; Toussaint, Arnaud; Rossier, Marie-Claude; De Sa, Renato Augusto Moreira; Grawe, Claudia; Aebi-Popp, Karoline; Radan, Anda-Petronela; Raio, Luigi; Surbek, Daniel; Böckenhoff, Paul; Strizek, Brigitte; Kaufmann, Martin; Bloch, Andrea; Boulvain, Michel; Johann, Silke; Heldstab, Sandra Andrea; Bernasconi, Monya Todesco; Grant, Gaston; Feki, Anis; Brochut, Anne-Claude Muller; Giral, Marylene; Sedille, Lucie; Papadia, Andrea; Brugger, Romina Capoccia; Weber, Brigitte; Fischer, Tina; Kahlert, Christian; Saines, Karin Nielsen; Cambou, Mary; Kanellos, Panagiotis; Chen, Xiang; Yin, Mingzhu; Haessig, Annina; Ackermann, Sandrine; Baud, David; Panchaud, Alice.

in: SCI REP-UK, Jahrgang 11, Nr. 1, 13898, 06.07.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vouga, M, Favre, G, Martinez-Perez, O, Pomar, L, Acebal, LF, Abascal-Saiz, A, Hernandez, MRV, Hcini, N, Lambert, V, Carles, G, Sichitiu, J, Salomon, L, Stirnemann, J, Ville, Y, de Tejada, BM, Goncé, A, Hawkins-Villarreal, A, Castillo, K, Solsona, EG, Trigo, L, Cleary, B, Geary, M, Bartels, H, Al-Kharouf, F, Malone, F, Higgins, M, Keating, N, Knowles, S, Poncelet, C, Ribeiro-do-Valle, CC, Surita, F, Dantas-Silva, A, Borrelli, C, Luz, AG, Fuenzalida, J, Carvajal, J, Canales, MG, Hernandez, O, Grechukhina, O, Ko, AI, Reddy, U, Figueiredo, R, Moucho, M, Pinto, PV, De Luca, C, De Santis, M, de Campos, DA, Martins, I, Garabedian, C, Subtil, D, Bohrer, B, Da Rocha Oppermann, ML, Wender, MCO, Schuler-Faccini, L, Sanseverino, MTV, Giugliani, C, Friedrich, L, Scherer, MH, Mottet, N, Ducarme, G, Pelerin, H, Moreau, C, Breton, B, Quibel, T, Rozenberg, P, Giannoni, E, Granado, C, Monod, C, Mueller, D, Hoesli, I, Bassler, D, Heldstab, S, Kölble, NO, Sentilhes, L, Charvet, M, Deprest, J, Richter, J, Van der Veeken, L, Eggel-Hort, B, Plantefeve, G, Derouich, M, Calvache, AJN, Lopez-Giron, MC, Burgos-Luna, JM, Escobar-Vidarte, MF, Hecher, K, Tallarek, A-C, Hadar, E, Haratz, KK, Amikam, U, Malinger, G, Maymon, R, Yogev, Y, Schäffer, L, Toussaint, A, Rossier, M-C, De Sa, RAM, Grawe, C, Aebi-Popp, K, Radan, A-P, Raio, L, Surbek, D, Böckenhoff, P, Strizek, B, Kaufmann, M, Bloch, A, Boulvain, M, Johann, S, Heldstab, SA, Bernasconi, MT, Grant, G, Feki, A, Brochut, A-CM, Giral, M, Sedille, L, Papadia, A, Brugger, RC, Weber, B, Fischer, T, Kahlert, C, Saines, KN, Cambou, M, Kanellos, P, Chen, X, Yin, M, Haessig, A, Ackermann, S, Baud, D & Panchaud, A 2021, 'Maternal outcomes and risk factors for COVID-19 severity among pregnant women', SCI REP-UK, Jg. 11, Nr. 1, 13898. https://doi.org/10.1038/s41598-021-92357-y

APA

Vouga, M., Favre, G., Martinez-Perez, O., Pomar, L., Acebal, L. F., Abascal-Saiz, A., Hernandez, M. R. V., Hcini, N., Lambert, V., Carles, G., Sichitiu, J., Salomon, L., Stirnemann, J., Ville, Y., de Tejada, B. M., Goncé, A., Hawkins-Villarreal, A., Castillo, K., Solsona, E. G., ... Panchaud, A. (2021). Maternal outcomes and risk factors for COVID-19 severity among pregnant women. SCI REP-UK, 11(1), [13898]. https://doi.org/10.1038/s41598-021-92357-y

Vancouver

Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. SCI REP-UK. 2021 Jul 6;11(1). 13898. https://doi.org/10.1038/s41598-021-92357-y

Bibtex

@article{a2a021c1260e4e509a540d02b3c25570,
title = "Maternal outcomes and risk factors for COVID-19 severity among pregnant women",
abstract = "Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.",
keywords = "Adult, COVID-19/virology, Case-Control Studies, Female, Humans, Pregnancy, Pregnancy Complications, Infectious/virology, Pregnancy Outcome, Pregnant Women, Premature Birth/virology, Risk Factors, SARS-CoV-2/pathogenicity",
author = "Manon Vouga and Guillaume Favre and Oscar Martinez-Perez and Leo Pomar and Acebal, {Laura Forcen} and Alejandra Abascal-Saiz and Hernandez, {Maria Rosa Vila} and Najeh Hcini and V{\'e}ronique Lambert and Gabriel Carles and Joanna Sichitiu and Laurent Salomon and Julien Stirnemann and Yves Ville and {de Tejada}, {Bego{\~n}a Martinez} and Anna Gonc{\'e} and Ameth Hawkins-Villarreal and Karen Castillo and Solsona, {Eduard Gratacos} and Lucas Trigo and Brian Cleary and Michael Geary and Helena Bartels and Feras Al-Kharouf and Fergal Malone and Mary Higgins and Niamh Keating and Susan Knowles and Christophe Poncelet and Ribeiro-do-Valle, {Carolina Carvalho} and Fernanda Surita and Amanda Dantas-Silva and Carolina Borrelli and Luz, {Adriana Gomes} and Javiera Fuenzalida and Jorge Carvajal and Canales, {Manuel Guerra} and Olivia Hernandez and Olga Grechukhina and Ko, {Albert I} and Uma Reddy and Rita Figueiredo and Marina Moucho and Pinto, {Pedro Viana} and {De Luca}, Carmen and {De Santis}, Marco and {de Campos}, {Diogo Ayres} and In{\^e}s Martins and Charles Garabedian and Damien Subtil and Betania Bohrer and {Da Rocha Oppermann}, {Maria Lucia} and Wender, {Maria Celeste Osorio} and Lavinia Schuler-Faccini and Sanseverino, {Maria Teresa Vieira} and Camila Giugliani and Luciana Friedrich and Scherer, {Mariana Horn} and Nicolas Mottet and Guillaume Ducarme and Helene Pelerin and Chloe Moreau and B{\'e}n{\'e}dicte Breton and Thibaud Quibel and Patrick Rozenberg and Eric Giannoni and Cristina Granado and C{\'e}cile Monod and Doris Mueller and Irene Hoesli and Dirk Bassler and Sandra Heldstab and K{\"o}lble, {Nicole Ochsenbein} and Lo{\"i}c Sentilhes and Melissa Charvet and Jan Deprest and Jute Richter and {Van der Veeken}, Lennart and B{\'e}atrice Eggel-Hort and Gaetan Plantefeve and Mohamed Derouich and Calvache, {Albaro Jos{\'e} Nieto} and Lopez-Giron, {Maria Camila} and Burgos-Luna, {Juan Manuel} and Escobar-Vidarte, {Maria Fernanda} and Kurt Hecher and Ann-Christin Tallarek and Eran Hadar and Haratz, {Karina Krajden} and Uri Amikam and Gustavo Malinger and Ron Maymon and Yariv Yogev and Leonhard Sch{\"a}ffer and Arnaud Toussaint and Marie-Claude Rossier and {De Sa}, {Renato Augusto Moreira} and Claudia Grawe and Karoline Aebi-Popp and Anda-Petronela Radan and Luigi Raio and Daniel Surbek and Paul B{\"o}ckenhoff and Brigitte Strizek and Martin Kaufmann and Andrea Bloch and Michel Boulvain and Silke Johann and Heldstab, {Sandra Andrea} and Bernasconi, {Monya Todesco} and Gaston Grant and Anis Feki and Brochut, {Anne-Claude Muller} and Marylene Giral and Lucie Sedille and Andrea Papadia and Brugger, {Romina Capoccia} and Brigitte Weber and Tina Fischer and Christian Kahlert and Saines, {Karin Nielsen} and Mary Cambou and Panagiotis Kanellos and Xiang Chen and Mingzhu Yin and Annina Haessig and Sandrine Ackermann and David Baud and Alice Panchaud",
year = "2021",
month = jul,
day = "6",
doi = "10.1038/s41598-021-92357-y",
language = "English",
volume = "11",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Maternal outcomes and risk factors for COVID-19 severity among pregnant women

AU - Vouga, Manon

AU - Favre, Guillaume

AU - Martinez-Perez, Oscar

AU - Pomar, Leo

AU - Acebal, Laura Forcen

AU - Abascal-Saiz, Alejandra

AU - Hernandez, Maria Rosa Vila

AU - Hcini, Najeh

AU - Lambert, Véronique

AU - Carles, Gabriel

AU - Sichitiu, Joanna

AU - Salomon, Laurent

AU - Stirnemann, Julien

AU - Ville, Yves

AU - de Tejada, Begoña Martinez

AU - Goncé, Anna

AU - Hawkins-Villarreal, Ameth

AU - Castillo, Karen

AU - Solsona, Eduard Gratacos

AU - Trigo, Lucas

AU - Cleary, Brian

AU - Geary, Michael

AU - Bartels, Helena

AU - Al-Kharouf, Feras

AU - Malone, Fergal

AU - Higgins, Mary

AU - Keating, Niamh

AU - Knowles, Susan

AU - Poncelet, Christophe

AU - Ribeiro-do-Valle, Carolina Carvalho

AU - Surita, Fernanda

AU - Dantas-Silva, Amanda

AU - Borrelli, Carolina

AU - Luz, Adriana Gomes

AU - Fuenzalida, Javiera

AU - Carvajal, Jorge

AU - Canales, Manuel Guerra

AU - Hernandez, Olivia

AU - Grechukhina, Olga

AU - Ko, Albert I

AU - Reddy, Uma

AU - Figueiredo, Rita

AU - Moucho, Marina

AU - Pinto, Pedro Viana

AU - De Luca, Carmen

AU - De Santis, Marco

AU - de Campos, Diogo Ayres

AU - Martins, Inês

AU - Garabedian, Charles

AU - Subtil, Damien

AU - Bohrer, Betania

AU - Da Rocha Oppermann, Maria Lucia

AU - Wender, Maria Celeste Osorio

AU - Schuler-Faccini, Lavinia

AU - Sanseverino, Maria Teresa Vieira

AU - Giugliani, Camila

AU - Friedrich, Luciana

AU - Scherer, Mariana Horn

AU - Mottet, Nicolas

AU - Ducarme, Guillaume

AU - Pelerin, Helene

AU - Moreau, Chloe

AU - Breton, Bénédicte

AU - Quibel, Thibaud

AU - Rozenberg, Patrick

AU - Giannoni, Eric

AU - Granado, Cristina

AU - Monod, Cécile

AU - Mueller, Doris

AU - Hoesli, Irene

AU - Bassler, Dirk

AU - Heldstab, Sandra

AU - Kölble, Nicole Ochsenbein

AU - Sentilhes, Loïc

AU - Charvet, Melissa

AU - Deprest, Jan

AU - Richter, Jute

AU - Van der Veeken, Lennart

AU - Eggel-Hort, Béatrice

AU - Plantefeve, Gaetan

AU - Derouich, Mohamed

AU - Calvache, Albaro José Nieto

AU - Lopez-Giron, Maria Camila

AU - Burgos-Luna, Juan Manuel

AU - Escobar-Vidarte, Maria Fernanda

AU - Hecher, Kurt

AU - Tallarek, Ann-Christin

AU - Hadar, Eran

AU - Haratz, Karina Krajden

AU - Amikam, Uri

AU - Malinger, Gustavo

AU - Maymon, Ron

AU - Yogev, Yariv

AU - Schäffer, Leonhard

AU - Toussaint, Arnaud

AU - Rossier, Marie-Claude

AU - De Sa, Renato Augusto Moreira

AU - Grawe, Claudia

AU - Aebi-Popp, Karoline

AU - Radan, Anda-Petronela

AU - Raio, Luigi

AU - Surbek, Daniel

AU - Böckenhoff, Paul

AU - Strizek, Brigitte

AU - Kaufmann, Martin

AU - Bloch, Andrea

AU - Boulvain, Michel

AU - Johann, Silke

AU - Heldstab, Sandra Andrea

AU - Bernasconi, Monya Todesco

AU - Grant, Gaston

AU - Feki, Anis

AU - Brochut, Anne-Claude Muller

AU - Giral, Marylene

AU - Sedille, Lucie

AU - Papadia, Andrea

AU - Brugger, Romina Capoccia

AU - Weber, Brigitte

AU - Fischer, Tina

AU - Kahlert, Christian

AU - Saines, Karin Nielsen

AU - Cambou, Mary

AU - Kanellos, Panagiotis

AU - Chen, Xiang

AU - Yin, Mingzhu

AU - Haessig, Annina

AU - Ackermann, Sandrine

AU - Baud, David

AU - Panchaud, Alice

PY - 2021/7/6

Y1 - 2021/7/6

N2 - Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.

AB - Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.

KW - Adult

KW - COVID-19/virology

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Pregnancy

KW - Pregnancy Complications, Infectious/virology

KW - Pregnancy Outcome

KW - Pregnant Women

KW - Premature Birth/virology

KW - Risk Factors

KW - SARS-CoV-2/pathogenicity

U2 - 10.1038/s41598-021-92357-y

DO - 10.1038/s41598-021-92357-y

M3 - SCORING: Journal article

C2 - 34230507

VL - 11

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 13898

ER -