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Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.

Standard

Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. / Stelekati, Erietta; Bahri, Rajia; D'Orlando, Orietta; Orinska, Zane; Mittrücker, Hans Willi; Langenhaun, Rabea; Glatzel, Markus; Bollinger, Annalena; Paus, Ralf; Bulfone-Paus, Silvia.

in: IMMUNITY, Jahrgang 31, Nr. 4, 4, 2009, S. 665-676.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stelekati, E, Bahri, R, D'Orlando, O, Orinska, Z, Mittrücker, HW, Langenhaun, R, Glatzel, M, Bollinger, A, Paus, R & Bulfone-Paus, S 2009, 'Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.', IMMUNITY, Jg. 31, Nr. 4, 4, S. 665-676. <http://www.ncbi.nlm.nih.gov/pubmed/19818652?dopt=Citation>

APA

Stelekati, E., Bahri, R., D'Orlando, O., Orinska, Z., Mittrücker, H. W., Langenhaun, R., Glatzel, M., Bollinger, A., Paus, R., & Bulfone-Paus, S. (2009). Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. IMMUNITY, 31(4), 665-676. [4]. http://www.ncbi.nlm.nih.gov/pubmed/19818652?dopt=Citation

Vancouver

Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrücker HW, Langenhaun R et al. Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. IMMUNITY. 2009;31(4):665-676. 4.

Bibtex

@article{96e372453643476f8757ebd37b9cd182,
title = "Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.",
abstract = "The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8(+) T cells have not been elucidated. Here, we demonstrated that MCs induced antigen-specific CD8(+) T cell activation and proliferation. This process required direct cell contact and MHC class I-dependent antigen cross-presentation by MCs and induced the secretion of interleukin-2, interferon-gamma, and macrophage inflammatory protein-1alpha by CD8(+) T cells. MCs regulated antigen-specific CD8(+) T cell cytotoxicity by increasing granzyme B expression and by promoting CD8(+) T cell degranulation. Because MCs also upregulated their expression of costimulatory molecules (4-1BB) and released osteopontin upon direct T cell contact, MC-T cell interactions probably are bidirectional. In vivo, adoptive transfer of antigen-pulsed MCs induced MHC class I-dependent, antigen-specific CD8(+) T cell proliferation, and MCs regulated CD8(+) T cell-specific priming in experimental autoimmune encephalomyelitis. Thus, MCs are important players in antigen-specific regulation of CD8(+) T cells.",
author = "Erietta Stelekati and Rajia Bahri and Orietta D'Orlando and Zane Orinska and Mittr{\"u}cker, {Hans Willi} and Rabea Langenhaun and Markus Glatzel and Annalena Bollinger and Ralf Paus and Silvia Bulfone-Paus",
year = "2009",
language = "Deutsch",
volume = "31",
pages = "665--676",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.

AU - Stelekati, Erietta

AU - Bahri, Rajia

AU - D'Orlando, Orietta

AU - Orinska, Zane

AU - Mittrücker, Hans Willi

AU - Langenhaun, Rabea

AU - Glatzel, Markus

AU - Bollinger, Annalena

AU - Paus, Ralf

AU - Bulfone-Paus, Silvia

PY - 2009

Y1 - 2009

N2 - The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8(+) T cells have not been elucidated. Here, we demonstrated that MCs induced antigen-specific CD8(+) T cell activation and proliferation. This process required direct cell contact and MHC class I-dependent antigen cross-presentation by MCs and induced the secretion of interleukin-2, interferon-gamma, and macrophage inflammatory protein-1alpha by CD8(+) T cells. MCs regulated antigen-specific CD8(+) T cell cytotoxicity by increasing granzyme B expression and by promoting CD8(+) T cell degranulation. Because MCs also upregulated their expression of costimulatory molecules (4-1BB) and released osteopontin upon direct T cell contact, MC-T cell interactions probably are bidirectional. In vivo, adoptive transfer of antigen-pulsed MCs induced MHC class I-dependent, antigen-specific CD8(+) T cell proliferation, and MCs regulated CD8(+) T cell-specific priming in experimental autoimmune encephalomyelitis. Thus, MCs are important players in antigen-specific regulation of CD8(+) T cells.

AB - The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8(+) T cells have not been elucidated. Here, we demonstrated that MCs induced antigen-specific CD8(+) T cell activation and proliferation. This process required direct cell contact and MHC class I-dependent antigen cross-presentation by MCs and induced the secretion of interleukin-2, interferon-gamma, and macrophage inflammatory protein-1alpha by CD8(+) T cells. MCs regulated antigen-specific CD8(+) T cell cytotoxicity by increasing granzyme B expression and by promoting CD8(+) T cell degranulation. Because MCs also upregulated their expression of costimulatory molecules (4-1BB) and released osteopontin upon direct T cell contact, MC-T cell interactions probably are bidirectional. In vivo, adoptive transfer of antigen-pulsed MCs induced MHC class I-dependent, antigen-specific CD8(+) T cell proliferation, and MCs regulated CD8(+) T cell-specific priming in experimental autoimmune encephalomyelitis. Thus, MCs are important players in antigen-specific regulation of CD8(+) T cells.

M3 - SCORING: Zeitschriftenaufsatz

VL - 31

SP - 665

EP - 676

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 4

M1 - 4

ER -