PortalPublikationenMass Spectrometric Comparison of HPV-Positive and HPV-Negati...

Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer

Standard

Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. / Wurlitzer, Marcus; Möckelmann, Nikolaus; Kriegs, Malte; Vens, Maren; Omidi, Maryam; Hoffer, Konstantin; Bargen, Clara von; Möller-Koop, Christina; Witt, Melanie; Droste, Conrad; Oetting, Agnes; Petersen, Hannes; Busch, Chia-Jung; Münscher, Adrian; Schlüter, Hartmut; Clauditz, Till Sebastian; Rieckmann, Thorsten.

in: CANCERS, Jahrgang 12, Nr. 6, 11.06.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wurlitzer, M, Möckelmann, N, Kriegs, M, Vens, M, Omidi, M, Hoffer, K, Bargen, CV, Möller-Koop, C, Witt, M, Droste, C, Oetting, A, Petersen, H, Busch, C-J, Münscher, A, Schlüter, H, Clauditz, TS & Rieckmann, T 2020, 'Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer', CANCERS, Jg. 12, Nr. 6. https://doi.org/10.3390/cancers12061531

APA

Wurlitzer, M., Möckelmann, N., Kriegs, M., Vens, M., Omidi, M., Hoffer, K., Bargen, C. V., Möller-Koop, C., Witt, M., Droste, C., Oetting, A., Petersen, H., Busch, C-J., Münscher, A., Schlüter, H., Clauditz, T. S., & Rieckmann, T. (2020). Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. CANCERS, 12(6). https://doi.org/10.3390/cancers12061531

Vancouver

Wurlitzer M, Möckelmann N, Kriegs M, Vens M, Omidi M, Hoffer K et al. Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer. CANCERS. 2020 Jun 11;12(6). https://doi.org/10.3390/cancers12061531

Bibtex

@article{c5face5809054496a67f40d950a83f1d,
title = "Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer",
abstract = "Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in many countries. HPV-positive HNSCC mostly arise in the oropharynx and are characterized by an enhanced sensitivity towards radiotherapy and a favorable prognosis. To identify molecular differences between both entities on the protein level, we conducted a mass spectrometric comparison of eight HPV-positive and nine HPV-negative oropharyngeal tumors (OPSCC). Overall, we identified 2051 proteins, of which 31 were found to be differentially expressed. Seventeen of these can be assorted to three functional groups, namely DNA replication, nuclear architecture and cytoskeleton regulation, with the differences in the last group potentially reflecting an enhanced migratory and invasive capacity. Furthermore, a number of identified proteins have been described to directly impact on DNA double-strand break repair or radiation sensitivity (e.g., SLC3A2, cortactin, RBBP4, Numa1), offering explanations for the differential prognosis. The unequal expression of three proteins (SLC3A2, MCM2 and lamin B1) was confirmed by immunohistochemical staining using a tissue microarray containing 205 OPSCC samples. The expression levels of SLC3A2 and lamin B1 were found be of prognostic relevance in patients with HPV-positive and HPV-negative OPSCC, respectively.",
author = "Marcus Wurlitzer and Nikolaus M{\"o}ckelmann and Malte Kriegs and Maren Vens and Maryam Omidi and Konstantin Hoffer and Bargen, {Clara von} and Christina M{\"o}ller-Koop and Melanie Witt and Conrad Droste and Agnes Oetting and Hannes Petersen and Chia-Jung Busch and Adrian M{\"u}nscher and Hartmut Schl{\"u}ter and Clauditz, {Till Sebastian} and Thorsten Rieckmann",
year = "2020",
month = jun,
day = "11",
doi = "10.3390/cancers12061531",
language = "English",
volume = "12",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

RIS

TY - JOUR

T1 - Mass Spectrometric Comparison of HPV-Positive and HPV-Negative Oropharyngeal Cancer

AU - Wurlitzer, Marcus

AU - Möckelmann, Nikolaus

AU - Kriegs, Malte

AU - Vens, Maren

AU - Omidi, Maryam

AU - Hoffer, Konstantin

AU - Bargen, Clara von

AU - Möller-Koop, Christina

AU - Witt, Melanie

AU - Droste, Conrad

AU - Oetting, Agnes

AU - Petersen, Hannes

AU - Busch, Chia-Jung

AU - Münscher, Adrian

AU - Schlüter, Hartmut

AU - Clauditz, Till Sebastian

AU - Rieckmann, Thorsten

PY - 2020/6/11

Y1 - 2020/6/11

N2 - Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in many countries. HPV-positive HNSCC mostly arise in the oropharynx and are characterized by an enhanced sensitivity towards radiotherapy and a favorable prognosis. To identify molecular differences between both entities on the protein level, we conducted a mass spectrometric comparison of eight HPV-positive and nine HPV-negative oropharyngeal tumors (OPSCC). Overall, we identified 2051 proteins, of which 31 were found to be differentially expressed. Seventeen of these can be assorted to three functional groups, namely DNA replication, nuclear architecture and cytoskeleton regulation, with the differences in the last group potentially reflecting an enhanced migratory and invasive capacity. Furthermore, a number of identified proteins have been described to directly impact on DNA double-strand break repair or radiation sensitivity (e.g., SLC3A2, cortactin, RBBP4, Numa1), offering explanations for the differential prognosis. The unequal expression of three proteins (SLC3A2, MCM2 and lamin B1) was confirmed by immunohistochemical staining using a tissue microarray containing 205 OPSCC samples. The expression levels of SLC3A2 and lamin B1 were found be of prognostic relevance in patients with HPV-positive and HPV-negative OPSCC, respectively.

AB - Squamous cell carcinoma of the head and neck (HNSCC) consist of two distinct biological entities. While the numbers of classical, tobacco-induced HNSCC are declining, tumors caused by human papillomavirus (HPV) infection are increasing in many countries. HPV-positive HNSCC mostly arise in the oropharynx and are characterized by an enhanced sensitivity towards radiotherapy and a favorable prognosis. To identify molecular differences between both entities on the protein level, we conducted a mass spectrometric comparison of eight HPV-positive and nine HPV-negative oropharyngeal tumors (OPSCC). Overall, we identified 2051 proteins, of which 31 were found to be differentially expressed. Seventeen of these can be assorted to three functional groups, namely DNA replication, nuclear architecture and cytoskeleton regulation, with the differences in the last group potentially reflecting an enhanced migratory and invasive capacity. Furthermore, a number of identified proteins have been described to directly impact on DNA double-strand break repair or radiation sensitivity (e.g., SLC3A2, cortactin, RBBP4, Numa1), offering explanations for the differential prognosis. The unequal expression of three proteins (SLC3A2, MCM2 and lamin B1) was confirmed by immunohistochemical staining using a tissue microarray containing 205 OPSCC samples. The expression levels of SLC3A2 and lamin B1 were found be of prognostic relevance in patients with HPV-positive and HPV-negative OPSCC, respectively.

U2 - 10.3390/cancers12061531

DO - 10.3390/cancers12061531

M3 - SCORING: Journal article

C2 - 32545200

VL - 12

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 6

ER -