Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms
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Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms. / Flondell-Sité, Despina; Lindblad, Bengt; Kölbel, Tilo; Gottsäter, Anders.
in: VASC ENDOVASC SURG, Jahrgang 44, Nr. 4, 05.2010, S. 262-268.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms
AU - Flondell-Sité, Despina
AU - Lindblad, Bengt
AU - Kölbel, Tilo
AU - Gottsäter, Anders
PY - 2010/5
Y1 - 2010/5
N2 - UNLABELLED: We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs).MATERIAL AND METHODS: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients.RESULTS: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth.CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified.
AB - UNLABELLED: We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs).MATERIAL AND METHODS: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients.RESULTS: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth.CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified.
KW - Aged
KW - Aged, 80 and over
KW - Aortic Aneurysm, Abdominal/blood
KW - Biomarkers/blood
KW - Blood Coagulation
KW - Case-Control Studies
KW - Disease Progression
KW - Female
KW - Fibrinolysis
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Matrix Metalloproteinase 2/blood
KW - Matrix Metalloproteinase 9/blood
KW - Middle Aged
KW - Peptide Hydrolases/blood
KW - Plasminogen Activator Inhibitor 1/blood
KW - Prospective Studies
KW - Protein C/metabolism
KW - Protein C Inhibitor/blood
KW - Sweden
KW - Time Factors
KW - Tissue Inhibitor of Metalloproteinase-1/blood
KW - Tissue Plasminogen Activator/blood
U2 - 10.1177/1538574410361971
DO - 10.1177/1538574410361971
M3 - SCORING: Journal article
C2 - 20356864
VL - 44
SP - 262
EP - 268
JO - VASC ENDOVASC SURG
JF - VASC ENDOVASC SURG
SN - 1538-5744
IS - 4
ER -
