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Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction

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Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction. / Schaub, Nora; Reichlin, Tobias; Meune, Christophe; Twerenbold, Raphael; Haaf, Philip; Hochholzer, Willibald; Niederhauser, Nadine; Bosshard, Piet; Stelzig, Claudia; Freese, Michael; Reiter, Miriam; Gea, Joachim; Buser, Andreas; Mebazaa, Alexandre; Osswald, Stefan; Mueller, Christian.

in: CLIN CHEM, Jahrgang 58, Nr. 1, 01.2012, S. 246-56.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schaub, N, Reichlin, T, Meune, C, Twerenbold, R, Haaf, P, Hochholzer, W, Niederhauser, N, Bosshard, P, Stelzig, C, Freese, M, Reiter, M, Gea, J, Buser, A, Mebazaa, A, Osswald, S & Mueller, C 2012, 'Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction', CLIN CHEM, Jg. 58, Nr. 1, S. 246-56. https://doi.org/10.1373/clinchem.2011.172940

APA

Schaub, N., Reichlin, T., Meune, C., Twerenbold, R., Haaf, P., Hochholzer, W., Niederhauser, N., Bosshard, P., Stelzig, C., Freese, M., Reiter, M., Gea, J., Buser, A., Mebazaa, A., Osswald, S., & Mueller, C. (2012). Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction. CLIN CHEM, 58(1), 246-56. https://doi.org/10.1373/clinchem.2011.172940

Vancouver

Schaub N, Reichlin T, Meune C, Twerenbold R, Haaf P, Hochholzer W et al. Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction. CLIN CHEM. 2012 Jan;58(1):246-56. https://doi.org/10.1373/clinchem.2011.172940

Bibtex

@article{85f3c5bc8e004dee9fb7ef64df460015,
title = "Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction",
abstract = "BACKGROUND: Plaque erosion and plaque rupture occur early in the pathophysiology of acute myocardial infarction (AMI). We hypothesized that markers of plaque instability might be useful in the early diagnosis and risk stratification of AMI.METHODS: In this multicenter study, we examined 4 markers of plaque instability, myeloperoxidase (MPO), myeloid-related protein 8/14 (MRP-8/14), pregnancy-associated plasma protein-A (PAPP-A), and C-reactive protein (CRP) in 398 consecutive patients presenting to the emergency department with acute chest pain and compared them to normal and high-sensitivity cardiac troponin T (cTnT and hs-cTnT). The final diagnosis was adjudicated by 2 independent cardiologists. Primary prognostic end point was death during a median follow-up of 27 months.RESULTS: The adjudicated final diagnosis was AMI in 76 patients (19%). At emergency department presentation, concentrations of all 4 biomarkers of plaque instability were significantly higher in patients with AMI than in patients with other diagnoses. However, their diagnostic accuracy as quantified by the area under the ROC curve (AUC) was low (MPO 0.63, MRP-8/14 0.65, PAPP-A 0.62, CRP 0.59) and inferior to both normal and high-sensitivity cardiac troponin T (cTnT 0.88, hs-cTnT 0.96; P<0.001 for all comparisons). Thirty-nine patients (10%) died during follow-up. Concentrations of MPO, MRP-8/14, and CRP were higher in nonsurvivors than in survivors and predicted all-cause mortality with moderate accuracy.CONCLUSIONS: Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain.",
keywords = "Acute Coronary Syndrome/diagnosis, Aged, Aged, 80 and over, Area Under Curve, Biomarkers/blood, C-Reactive Protein/analysis, Calgranulin A/blood, Calgranulin B/blood, Chest Pain/blood, Early Diagnosis, Female, Humans, Male, Middle Aged, Myocardial Infarction/diagnosis, Peroxidase/blood, Plaque, Atherosclerotic/complications, Pregnancy-Associated Plasma Protein-A/analysis, Prognosis, ROC Curve, Risk Assessment, Troponin T/blood",
author = "Nora Schaub and Tobias Reichlin and Christophe Meune and Raphael Twerenbold and Philip Haaf and Willibald Hochholzer and Nadine Niederhauser and Piet Bosshard and Claudia Stelzig and Michael Freese and Miriam Reiter and Joachim Gea and Andreas Buser and Alexandre Mebazaa and Stefan Osswald and Christian Mueller",
year = "2012",
month = jan,
doi = "10.1373/clinchem.2011.172940",
language = "English",
volume = "58",
pages = "246--56",
journal = "CLIN CHEM",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Markers of plaque instability in the early diagnosis and risk stratification of acute myocardial infarction

AU - Schaub, Nora

AU - Reichlin, Tobias

AU - Meune, Christophe

AU - Twerenbold, Raphael

AU - Haaf, Philip

AU - Hochholzer, Willibald

AU - Niederhauser, Nadine

AU - Bosshard, Piet

AU - Stelzig, Claudia

AU - Freese, Michael

AU - Reiter, Miriam

AU - Gea, Joachim

AU - Buser, Andreas

AU - Mebazaa, Alexandre

AU - Osswald, Stefan

AU - Mueller, Christian

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND: Plaque erosion and plaque rupture occur early in the pathophysiology of acute myocardial infarction (AMI). We hypothesized that markers of plaque instability might be useful in the early diagnosis and risk stratification of AMI.METHODS: In this multicenter study, we examined 4 markers of plaque instability, myeloperoxidase (MPO), myeloid-related protein 8/14 (MRP-8/14), pregnancy-associated plasma protein-A (PAPP-A), and C-reactive protein (CRP) in 398 consecutive patients presenting to the emergency department with acute chest pain and compared them to normal and high-sensitivity cardiac troponin T (cTnT and hs-cTnT). The final diagnosis was adjudicated by 2 independent cardiologists. Primary prognostic end point was death during a median follow-up of 27 months.RESULTS: The adjudicated final diagnosis was AMI in 76 patients (19%). At emergency department presentation, concentrations of all 4 biomarkers of plaque instability were significantly higher in patients with AMI than in patients with other diagnoses. However, their diagnostic accuracy as quantified by the area under the ROC curve (AUC) was low (MPO 0.63, MRP-8/14 0.65, PAPP-A 0.62, CRP 0.59) and inferior to both normal and high-sensitivity cardiac troponin T (cTnT 0.88, hs-cTnT 0.96; P<0.001 for all comparisons). Thirty-nine patients (10%) died during follow-up. Concentrations of MPO, MRP-8/14, and CRP were higher in nonsurvivors than in survivors and predicted all-cause mortality with moderate accuracy.CONCLUSIONS: Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain.

AB - BACKGROUND: Plaque erosion and plaque rupture occur early in the pathophysiology of acute myocardial infarction (AMI). We hypothesized that markers of plaque instability might be useful in the early diagnosis and risk stratification of AMI.METHODS: In this multicenter study, we examined 4 markers of plaque instability, myeloperoxidase (MPO), myeloid-related protein 8/14 (MRP-8/14), pregnancy-associated plasma protein-A (PAPP-A), and C-reactive protein (CRP) in 398 consecutive patients presenting to the emergency department with acute chest pain and compared them to normal and high-sensitivity cardiac troponin T (cTnT and hs-cTnT). The final diagnosis was adjudicated by 2 independent cardiologists. Primary prognostic end point was death during a median follow-up of 27 months.RESULTS: The adjudicated final diagnosis was AMI in 76 patients (19%). At emergency department presentation, concentrations of all 4 biomarkers of plaque instability were significantly higher in patients with AMI than in patients with other diagnoses. However, their diagnostic accuracy as quantified by the area under the ROC curve (AUC) was low (MPO 0.63, MRP-8/14 0.65, PAPP-A 0.62, CRP 0.59) and inferior to both normal and high-sensitivity cardiac troponin T (cTnT 0.88, hs-cTnT 0.96; P<0.001 for all comparisons). Thirty-nine patients (10%) died during follow-up. Concentrations of MPO, MRP-8/14, and CRP were higher in nonsurvivors than in survivors and predicted all-cause mortality with moderate accuracy.CONCLUSIONS: Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain.

KW - Acute Coronary Syndrome/diagnosis

KW - Aged

KW - Aged, 80 and over

KW - Area Under Curve

KW - Biomarkers/blood

KW - C-Reactive Protein/analysis

KW - Calgranulin A/blood

KW - Calgranulin B/blood

KW - Chest Pain/blood

KW - Early Diagnosis

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Peroxidase/blood

KW - Plaque, Atherosclerotic/complications

KW - Pregnancy-Associated Plasma Protein-A/analysis

KW - Prognosis

KW - ROC Curve

KW - Risk Assessment

KW - Troponin T/blood

U2 - 10.1373/clinchem.2011.172940

DO - 10.1373/clinchem.2011.172940

M3 - SCORING: Journal article

C2 - 22057876

VL - 58

SP - 246

EP - 256

JO - CLIN CHEM

JF - CLIN CHEM

SN - 0009-9147

IS - 1

ER -