Mapping the genetic variation of executive attention onto brain activity
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Mapping the genetic variation of executive attention onto brain activity. / Fan, Jin; Fossella, John; Sommer-Blöchl, Tobias; Wu, Yanghong; Posner, Michael I.
in: P NATL ACAD SCI USA, Jahrgang 100, Nr. 12, 10.06.2003, S. 7406-11.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Mapping the genetic variation of executive attention onto brain activity
AU - Fan, Jin
AU - Fossella, John
AU - Sommer-Blöchl, Tobias
AU - Wu, Yanghong
AU - Posner, Michael I
PY - 2003/6/10
Y1 - 2003/6/10
N2 - Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in the brain network mediating conflict. We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences in the Attention Network Test (ANT). To examine whether this genetic variation might contribute to differences in brain activation within the anterior cingulate cortex, we genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the ANT. In each of the two genes previously associated with more efficient handling of conflict in reaction time experiments, we found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the ANT than those with the allele associated with worse performance. The results demonstrate how genetic differences among individuals can be linked to individual differences in neuromodulators and in the efficiency of the operation of an appropriate attentional network.
AB - Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in the brain network mediating conflict. We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences in the Attention Network Test (ANT). To examine whether this genetic variation might contribute to differences in brain activation within the anterior cingulate cortex, we genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the ANT. In each of the two genes previously associated with more efficient handling of conflict in reaction time experiments, we found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the ANT than those with the allele associated with worse performance. The results demonstrate how genetic differences among individuals can be linked to individual differences in neuromodulators and in the efficiency of the operation of an appropriate attentional network.
KW - Adolescent
KW - Adult
KW - Alleles
KW - Attention
KW - Base Sequence
KW - Brain Mapping
KW - Conflict (Psychology)
KW - DNA
KW - Female
KW - Genetic Variation
KW - Gyrus Cinguli
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Monoamine Oxidase
KW - Polymorphism, Genetic
KW - Receptors, Dopamine D2
KW - Receptors, Dopamine D4
U2 - 10.1073/pnas.0732088100
DO - 10.1073/pnas.0732088100
M3 - SCORING: Journal article
C2 - 12773616
VL - 100
SP - 7406
EP - 7411
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 12
ER -
