Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants
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Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants. / Hartz, Annika; Schreiter, Lena; Pagel, Julia; Moser, Katja; Wieg, Christian; Grotheer, Anneke; Rupp, Jan; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph.
in: PEDIATR RES, Jahrgang 84, Nr. 1, 07.2018, S. 134-138.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants
AU - Hartz, Annika
AU - Schreiter, Lena
AU - Pagel, Julia
AU - Moser, Katja
AU - Wieg, Christian
AU - Grotheer, Anneke
AU - Rupp, Jan
AU - Herting, Egbert
AU - Göpel, Wolfgang
AU - Härtel, Christoph
PY - 2018/7
Y1 - 2018/7
N2 - OBJECTIVE: The aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infants (VLBWI).METHODS: MBL and MASP2 were measured in plasma samples of n = 89 VLBWI using ELISA and correlated with clinical parameters. MBL plasma levels were aligned with genotyping data of mbl2 exon 1 polymorphisms, rs1800450, rs1800451, and rs5030737.RESULTS: MBL levels were clearly determined by MBL genotype, i.e., AA individuals had tenfold higher MBL levels than AO individuals. MBL and MASP2 levels did not correlate with gestational age, apart from MASP2 levels on day 7. During the first 21 days of life, we noted a gradual increase in both MBL and MASP2 levels. On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants.CONCLUSIONS: In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life. Lower MASP2 levels on day 7 may indicate increased risk for late-onset infection.
AB - OBJECTIVE: The aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infants (VLBWI).METHODS: MBL and MASP2 were measured in plasma samples of n = 89 VLBWI using ELISA and correlated with clinical parameters. MBL plasma levels were aligned with genotyping data of mbl2 exon 1 polymorphisms, rs1800450, rs1800451, and rs5030737.RESULTS: MBL levels were clearly determined by MBL genotype, i.e., AA individuals had tenfold higher MBL levels than AO individuals. MBL and MASP2 levels did not correlate with gestational age, apart from MASP2 levels on day 7. During the first 21 days of life, we noted a gradual increase in both MBL and MASP2 levels. On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants.CONCLUSIONS: In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life. Lower MASP2 levels on day 7 may indicate increased risk for late-onset infection.
KW - Birth Weight
KW - Exons
KW - Female
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Gestational Age
KW - Humans
KW - Infant, Newborn
KW - Infant, Very Low Birth Weight
KW - Male
KW - Mannose-Binding Lectin/blood
KW - Mannose-Binding Protein-Associated Serine Proteases/analysis
KW - Polymorphism, Genetic
KW - Polymorphism, Single Nucleotide
KW - Premature Birth
KW - Prospective Studies
KW - Sepsis/blood
U2 - 10.1038/s41390-018-0017-9
DO - 10.1038/s41390-018-0017-9
M3 - SCORING: Journal article
C2 - 29807983
VL - 84
SP - 134
EP - 138
JO - PEDIATR RES
JF - PEDIATR RES
SN - 0031-3998
IS - 1
ER -
