Mandibular bone loss in ewe induced by hypothalamic-pituitary disconnection
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Mandibular bone loss in ewe induced by hypothalamic-pituitary disconnection. / Oheim, Ralf; Beil, F Timo; Krause, Matthias; Bindl, Ronny; Ignatius, Anita; Pogoda, Pia.
in: CLIN ORAL IMPLAN RES, Jahrgang 25, Nr. 11, 01.11.2014, S. 1239-1244.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Mandibular bone loss in ewe induced by hypothalamic-pituitary disconnection
AU - Oheim, Ralf
AU - Beil, F Timo
AU - Krause, Matthias
AU - Bindl, Ronny
AU - Ignatius, Anita
AU - Pogoda, Pia
N1 - © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - PURPOSE: It is supposed that the demographic change will lead to an increase in patients with impaired alveolar bone conditions. Large animal models are of particular interest in this context as they are suitable for developing and testing new dental implants. Recently, we demonstrated that surgical hypothalamo-pituitary disconnection (HPD) causes a pronounced low-turnover situation leading to cortical and trabecular bone loss in sheep. In this study, we aimed to investigate the influence of the HPD procedure on the alveolar bone.METHODS: Ten adult Merino ewes were randomly assigned to two groups: Control and HPD. After 6 months, we analysed the cortical and trabecular bone of all mandibles by histomorphometry and high-resolution peripheral quantitative computed tomography (HR-pQCT).RESULTS: HPD ewes showed a significant decrease in cortical thickness by ~20%, a significant increase in cortical porosity by ~20% and a significant decrease in bone volume by ~30% in comparison with Control ewes.CONCLUSION: Our results underline the importance of central regulatory mechanisms of bone turnover. However, further studies are needed to understand these central regulatory elements of bone turnover in detail and to judge the value of the HPD sheep for dental research.
AB - PURPOSE: It is supposed that the demographic change will lead to an increase in patients with impaired alveolar bone conditions. Large animal models are of particular interest in this context as they are suitable for developing and testing new dental implants. Recently, we demonstrated that surgical hypothalamo-pituitary disconnection (HPD) causes a pronounced low-turnover situation leading to cortical and trabecular bone loss in sheep. In this study, we aimed to investigate the influence of the HPD procedure on the alveolar bone.METHODS: Ten adult Merino ewes were randomly assigned to two groups: Control and HPD. After 6 months, we analysed the cortical and trabecular bone of all mandibles by histomorphometry and high-resolution peripheral quantitative computed tomography (HR-pQCT).RESULTS: HPD ewes showed a significant decrease in cortical thickness by ~20%, a significant increase in cortical porosity by ~20% and a significant decrease in bone volume by ~30% in comparison with Control ewes.CONCLUSION: Our results underline the importance of central regulatory mechanisms of bone turnover. However, further studies are needed to understand these central regulatory elements of bone turnover in detail and to judge the value of the HPD sheep for dental research.
U2 - 10.1111/clr.12259
DO - 10.1111/clr.12259
M3 - SCORING: Journal article
C2 - 24102843
VL - 25
SP - 1239
EP - 1244
JO - CLIN ORAL IMPLAN RES
JF - CLIN ORAL IMPLAN RES
SN - 0905-7161
IS - 11
ER -
