Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia

Froukje B van Hoeij; Fraukje A Ponds; Yuki Werner; Joel M Sternbach; Paul Fockens; Barbara A Bastiaansen; André J P M Smout; John E Pandolfino; Thomas Rösch; Albert J Bredenoord

doi:10.1016/j.gie.2017.04.036

Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia

Standard

Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia. / van Hoeij, Froukje B; Ponds, Fraukje A; Werner, Yuki; Sternbach, Joel M; Fockens, Paul; Bastiaansen, Barbara A; Smout, André J P M; Pandolfino, John E; Rösch, Thomas; Bredenoord, Albert J.

in: GASTROINTEST ENDOSC, Jahrgang 87, Nr. 1, 01.2018, S. 95-101.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

van Hoeij, FB, Ponds, FA, Werner, Y, Sternbach, JM, Fockens, P, Bastiaansen, BA, Smout, AJPM, Pandolfino, JE, Rösch, T & Bredenoord, AJ 2018, 'Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia', GASTROINTEST ENDOSC, Jg. 87, Nr. 1, S. 95-101. https://doi.org/10.1016/j.gie.2017.04.036

APA

van Hoeij, F. B., Ponds, F. A., Werner, Y., Sternbach, J. M., Fockens, P., Bastiaansen, B. A., Smout, A. J. P. M., Pandolfino, J. E., Rösch, T., & Bredenoord, A. J. (2018). Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia. GASTROINTEST ENDOSC, 87(1), 95-101. https://doi.org/10.1016/j.gie.2017.04.036

Vancouver

van Hoeij FB, Ponds FA, Werner Y, Sternbach JM, Fockens P, Bastiaansen BA et al. Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia. GASTROINTEST ENDOSC. 2018 Jan;87(1):95-101. https://doi.org/10.1016/j.gie.2017.04.036

Bibtex

@article{23b74daccbf947f1a0502bd273d25880,

title = "Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia",

abstract = "BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) has been rapidly gaining ground as a treatment for achalasia. Although POEM is a safe and effective treatment, a subset of patients has persistent or recurrent symptoms after POEM. This study aimed to examine the efficacy of different retreatments after failed POEM.METHODS: POEM was performed on 441 patients with achalasia at 3 tertiary-care hospitals between 2010 and 2015. A review of prospectively collected data was conducted. All patients with achalasia with significant persistent or recurrent symptoms within 3 years after POEM, defined as an Eckardt symptom score >3, were included.RESULTS: Forty-three of 441 patients (9.8%) had persistent or recurrent symptoms after POEM, of which 34 (8%) received 1 or more retreatments. Retreatment with laparoscopic Heller myotomy and retreatment with POEM showed a modest efficacy of 45% and 63%, respectively, whereas pneumatic dilatation showed a poor efficacy of only 0% to 20%, depending on the size of the balloon. Male patients were more likely to have retreatment failure than female patients (P = .038).CONCLUSIONS: In patients with achalasia with persistent or recurrent symptoms after failed POEM, retreatment with laparoscopic Heller myotomy or retreatment with POEM has a higher efficacy than retreatment with pneumatic dilatations. Failure of retreatment occurred more often in male patients.",

keywords = "Journal Article",

author = "{van Hoeij}, {Froukje B} and Ponds, {Fraukje A} and Yuki Werner and Sternbach, {Joel M} and Paul Fockens and Bastiaansen, {Barbara A} and Smout, {Andr{\'e} J P M} and Pandolfino, {John E} and Thomas R{\"o}sch and Bredenoord, {Albert J}",

year = "2018",

month = jan,

doi = "10.1016/j.gie.2017.04.036",

language = "English",

volume = "87",

pages = "95--101",

journal = "GASTROINTEST ENDOSC",

issn = "0016-5107",

publisher = "Mosby Inc.",

number = "1",

}

RIS

TY - JOUR

T1 - Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia

AU - van Hoeij, Froukje B

AU - Ponds, Fraukje A

AU - Werner, Yuki

AU - Sternbach, Joel M

AU - Fockens, Paul

AU - Bastiaansen, Barbara A

AU - Smout, André J P M

AU - Pandolfino, John E

AU - Rösch, Thomas

AU - Bredenoord, Albert J

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) has been rapidly gaining ground as a treatment for achalasia. Although POEM is a safe and effective treatment, a subset of patients has persistent or recurrent symptoms after POEM. This study aimed to examine the efficacy of different retreatments after failed POEM.METHODS: POEM was performed on 441 patients with achalasia at 3 tertiary-care hospitals between 2010 and 2015. A review of prospectively collected data was conducted. All patients with achalasia with significant persistent or recurrent symptoms within 3 years after POEM, defined as an Eckardt symptom score >3, were included.RESULTS: Forty-three of 441 patients (9.8%) had persistent or recurrent symptoms after POEM, of which 34 (8%) received 1 or more retreatments. Retreatment with laparoscopic Heller myotomy and retreatment with POEM showed a modest efficacy of 45% and 63%, respectively, whereas pneumatic dilatation showed a poor efficacy of only 0% to 20%, depending on the size of the balloon. Male patients were more likely to have retreatment failure than female patients (P = .038).CONCLUSIONS: In patients with achalasia with persistent or recurrent symptoms after failed POEM, retreatment with laparoscopic Heller myotomy or retreatment with POEM has a higher efficacy than retreatment with pneumatic dilatations. Failure of retreatment occurred more often in male patients.

AB - BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) has been rapidly gaining ground as a treatment for achalasia. Although POEM is a safe and effective treatment, a subset of patients has persistent or recurrent symptoms after POEM. This study aimed to examine the efficacy of different retreatments after failed POEM.METHODS: POEM was performed on 441 patients with achalasia at 3 tertiary-care hospitals between 2010 and 2015. A review of prospectively collected data was conducted. All patients with achalasia with significant persistent or recurrent symptoms within 3 years after POEM, defined as an Eckardt symptom score >3, were included.RESULTS: Forty-three of 441 patients (9.8%) had persistent or recurrent symptoms after POEM, of which 34 (8%) received 1 or more retreatments. Retreatment with laparoscopic Heller myotomy and retreatment with POEM showed a modest efficacy of 45% and 63%, respectively, whereas pneumatic dilatation showed a poor efficacy of only 0% to 20%, depending on the size of the balloon. Male patients were more likely to have retreatment failure than female patients (P = .038).CONCLUSIONS: In patients with achalasia with persistent or recurrent symptoms after failed POEM, retreatment with laparoscopic Heller myotomy or retreatment with POEM has a higher efficacy than retreatment with pneumatic dilatations. Failure of retreatment occurred more often in male patients.

KW - Journal Article

U2 - 10.1016/j.gie.2017.04.036

DO - 10.1016/j.gie.2017.04.036

M3 - SCORING: Journal article

C2 - 28478028

VL - 87

SP - 95

EP - 101

JO - GASTROINTEST ENDOSC

JF - GASTROINTEST ENDOSC

SN - 0016-5107

IS - 1

ER -