Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021
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Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021. / Gillessen, Silke; Armstrong, Andrew; Attard, Gert; Beer, Tomasz M; Beltran, Himisha; Bjartell, Anders; Bossi, Alberto; Briganti, Alberto; Bristow, Robert G; Bulbul, Muhammad; Caffo, Orazio; Chi, Kim N; Clarke, Caroline S; Clarke, Noel; Davis, Ian D; de Bono, Johann S; Duran, Ignacio; Eeles, Ros; Efstathiou, Eleni; Efstathiou, Jason; Ekeke, Onyeanunam Ngozi; Evans, Christopher P; Fanti, Stefano; Feng, Felix Y; Fizazi, Karim; Frydenberg, Mark; George, Dan; Gleave, Martin; Halabi, Susan; Heinrich, Daniel; Higano, Celesta; Hofman, Michael S; Hussain, Maha; James, Nick; Jones, Robert; Kanesvaran, Ravindran; Khauli, Raja B; Klotz, Laurence; Leibowitz, Raya; Logothetis, Chris; Maluf, Fernando; Millman, Robin; Morgans, Alicia K; Morris, Michael J; Mottet, Nicolas; Mrabti, Hind; Murphy, Declan G; Murthy, Vedang; Oh, William K; Ost, Piet; O'Sullivan, Joe M; Padhani, Anwar R; Parker, Chris; Poon, Darren M C; Pritchard, Colin C; Rabah, Danny M; Rathkopf, Dana; Reiter, Rob E; Rubin, Mark; Ryan, Charles J; Saad, Fred; Sade, Juan P; Sartor, Oliver; Scher, Howard I; Shore, Neal; Skoneczna, Iwona; Small, Eric; Smith, Matthew; Soule, Howard; Spratt, Daniel E; Sternberg, Cora N; Suzuki, Hiroyoshi; Sweeney, Christopher; Sydes, Matthew R; Taplin, Mary-Ellen; Tilki, Derya; Tombal, Bertrand; Türkeri, Levent; Uemura, Hiroji; Uemura, Hirotsugu; van Oort, Inge; Yamoah, Kosj; Ye, Dingwei; Zapatero, Almudena; Omlin, Aurelius.
in: EUR UROL, Jahrgang 82, Nr. 1, 07.2022, S. 115-141.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021
AU - Gillessen, Silke
AU - Armstrong, Andrew
AU - Attard, Gert
AU - Beer, Tomasz M
AU - Beltran, Himisha
AU - Bjartell, Anders
AU - Bossi, Alberto
AU - Briganti, Alberto
AU - Bristow, Robert G
AU - Bulbul, Muhammad
AU - Caffo, Orazio
AU - Chi, Kim N
AU - Clarke, Caroline S
AU - Clarke, Noel
AU - Davis, Ian D
AU - de Bono, Johann S
AU - Duran, Ignacio
AU - Eeles, Ros
AU - Efstathiou, Eleni
AU - Efstathiou, Jason
AU - Ekeke, Onyeanunam Ngozi
AU - Evans, Christopher P
AU - Fanti, Stefano
AU - Feng, Felix Y
AU - Fizazi, Karim
AU - Frydenberg, Mark
AU - George, Dan
AU - Gleave, Martin
AU - Halabi, Susan
AU - Heinrich, Daniel
AU - Higano, Celesta
AU - Hofman, Michael S
AU - Hussain, Maha
AU - James, Nick
AU - Jones, Robert
AU - Kanesvaran, Ravindran
AU - Khauli, Raja B
AU - Klotz, Laurence
AU - Leibowitz, Raya
AU - Logothetis, Chris
AU - Maluf, Fernando
AU - Millman, Robin
AU - Morgans, Alicia K
AU - Morris, Michael J
AU - Mottet, Nicolas
AU - Mrabti, Hind
AU - Murphy, Declan G
AU - Murthy, Vedang
AU - Oh, William K
AU - Ost, Piet
AU - O'Sullivan, Joe M
AU - Padhani, Anwar R
AU - Parker, Chris
AU - Poon, Darren M C
AU - Pritchard, Colin C
AU - Rabah, Danny M
AU - Rathkopf, Dana
AU - Reiter, Rob E
AU - Rubin, Mark
AU - Ryan, Charles J
AU - Saad, Fred
AU - Sade, Juan P
AU - Sartor, Oliver
AU - Scher, Howard I
AU - Shore, Neal
AU - Skoneczna, Iwona
AU - Small, Eric
AU - Smith, Matthew
AU - Soule, Howard
AU - Spratt, Daniel E
AU - Sternberg, Cora N
AU - Suzuki, Hiroyoshi
AU - Sweeney, Christopher
AU - Sydes, Matthew R
AU - Taplin, Mary-Ellen
AU - Tilki, Derya
AU - Tombal, Bertrand
AU - Türkeri, Levent
AU - Uemura, Hiroji
AU - Uemura, Hirotsugu
AU - van Oort, Inge
AU - Yamoah, Kosj
AU - Ye, Dingwei
AU - Zapatero, Almudena
AU - Omlin, Aurelius
N1 - Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - BACKGROUND: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but various areas of management still lack high-level evidence to inform clinical practice. The 2021 Advanced Prostate Cancer Consensus Conference (APCCC) addressed some of these questions to supplement guidelines that are based on level 1 evidence.OBJECTIVE: To present the voting results from APCCC 2021.DESIGN, SETTING, AND PARTICIPANTS: The experts identified three major areas of controversy related to management of advanced prostate cancer: newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC), the use of prostate-specific membrane antigen ligands in diagnostics and therapy, and molecular characterisation of tissue and blood. A panel of 86 international prostate cancer experts developed the programme and the consensus questions.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The panel voted publicly but anonymously on 107 pre-defined questions, which were developed by both voting and non-voting panel members prior to the conference following a modified Delphi process.RESULTS AND LIMITATIONS: The voting reflected the opinions of panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results reported in the Supplementary material.CONCLUSIONS: These voting results from a panel of experts in advanced prostate cancer can help clinicians and patients to navigate controversial areas of management for which high-level evidence is scant. However, diagnostic and treatment decisions should always be individualised according to patient characteristics, such as the extent and location of disease, prior treatment(s), comorbidities, patient preferences, and treatment recommendations, and should also incorporate current and emerging clinical evidence and logistic and economic constraints. Enrolment in clinical trials should be strongly encouraged. Importantly, APCCC 2021 once again identified salient questions that merit evaluation in specifically designed trials.PATIENT SUMMARY: The Advanced Prostate Cancer Consensus Conference is a forum for discussing current diagnosis and treatment options for patients with advanced prostate cancer. An expert panel votes on predefined questions focused on the most clinically relevant areas for treatment of advanced prostate cancer for which there are gaps in knowledge. The voting results provide a practical guide to help clinicians in discussing treatment options with patients as part of shared decision-making.
AB - BACKGROUND: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but various areas of management still lack high-level evidence to inform clinical practice. The 2021 Advanced Prostate Cancer Consensus Conference (APCCC) addressed some of these questions to supplement guidelines that are based on level 1 evidence.OBJECTIVE: To present the voting results from APCCC 2021.DESIGN, SETTING, AND PARTICIPANTS: The experts identified three major areas of controversy related to management of advanced prostate cancer: newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC), the use of prostate-specific membrane antigen ligands in diagnostics and therapy, and molecular characterisation of tissue and blood. A panel of 86 international prostate cancer experts developed the programme and the consensus questions.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The panel voted publicly but anonymously on 107 pre-defined questions, which were developed by both voting and non-voting panel members prior to the conference following a modified Delphi process.RESULTS AND LIMITATIONS: The voting reflected the opinions of panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results reported in the Supplementary material.CONCLUSIONS: These voting results from a panel of experts in advanced prostate cancer can help clinicians and patients to navigate controversial areas of management for which high-level evidence is scant. However, diagnostic and treatment decisions should always be individualised according to patient characteristics, such as the extent and location of disease, prior treatment(s), comorbidities, patient preferences, and treatment recommendations, and should also incorporate current and emerging clinical evidence and logistic and economic constraints. Enrolment in clinical trials should be strongly encouraged. Importantly, APCCC 2021 once again identified salient questions that merit evaluation in specifically designed trials.PATIENT SUMMARY: The Advanced Prostate Cancer Consensus Conference is a forum for discussing current diagnosis and treatment options for patients with advanced prostate cancer. An expert panel votes on predefined questions focused on the most clinically relevant areas for treatment of advanced prostate cancer for which there are gaps in knowledge. The voting results provide a practical guide to help clinicians in discussing treatment options with patients as part of shared decision-making.
KW - Consensus
KW - Humans
KW - Male
KW - Prostatic Neoplasms/diagnosis
U2 - 10.1016/j.eururo.2022.04.002
DO - 10.1016/j.eururo.2022.04.002
M3 - SCORING: Journal article
C2 - 35450732
VL - 82
SP - 115
EP - 141
JO - EUR UROL
JF - EUR UROL
SN - 0302-2838
IS - 1
ER -