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Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.

Standard

Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells. / Miroci, Hatmone; Schob, Claudia; Kindler, Stefan; Ölschläger-Schütt, Janin; Fehr, Susanne; Jungenitz, Tassilo; Schwarzacher, Stephan W; Bagni, Claudia; Mohr, Evita.

in: J BIOL CHEM, Jahrgang 287, Nr. 2, 2, 2012, S. 1322-1334.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Miroci, H, Schob, C, Kindler, S, Ölschläger-Schütt, J, Fehr, S, Jungenitz, T, Schwarzacher, SW, Bagni, C & Mohr, E 2012, 'Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.', J BIOL CHEM, Jg. 287, Nr. 2, 2, S. 1322-1334. <http://www.ncbi.nlm.nih.gov/pubmed/22128154?dopt=Citation>

APA

Miroci, H., Schob, C., Kindler, S., Ölschläger-Schütt, J., Fehr, S., Jungenitz, T., Schwarzacher, S. W., Bagni, C., & Mohr, E. (2012). Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells. J BIOL CHEM, 287(2), 1322-1334. [2]. http://www.ncbi.nlm.nih.gov/pubmed/22128154?dopt=Citation

Vancouver

Miroci H, Schob C, Kindler S, Ölschläger-Schütt J, Fehr S, Jungenitz T et al. Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells. J BIOL CHEM. 2012;287(2):1322-1334. 2.

Bibtex

@article{fc531894ee3f49e6a23c8f0030a64a22,
title = "Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.",
abstract = "The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein complexes, plays a crucial role in the control of mRNA translation rates, stability, and subcellular targeting. In this study we identify RING zinc finger protein Makorin 1 (MKRN1), a bona fide RNA-binding protein, as a binding partner of PABP that interacts with PABP in an RNA-independent manner. In rat brain, a so far uncharacterized short MKRN1 isoform, MKRN1-short, predominates and is detected in forebrain nerve cells. In neuronal dendrites, MKRN1-short co-localizes with PABP in granule-like structures, which are morphological correlates of sites of mRNA metabolism. Moreover, in primary rat neurons MKRN1-short associates with dendritically localized mRNAs. When tethered to a reporter mRNA, MKRN1-short significantly enhances reporter protein synthesis. Furthermore, after induction of synaptic plasticity via electrical stimulation of the perforant path in vivo, MKRN1-short specifically accumulates in the activated dendritic lamina, the middle molecular layer of the hippocampal dentate gyrus. Collectively, these data indicate that in mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses.",
keywords = "Animals, Male, Rats, Rats, Sprague-Dawley, Dendrites/genetics/*metabolism, Dentate Gyrus/cytology/*metabolism, Nerve Tissue Proteins/genetics/*metabolism, Neuronal Plasticity/physiology, Poly(A)-Binding Proteins/genetics/*metabolism, Protein Biosynthesis/*physiology, Protein Isoforms/genetics/metabolism, RNA, Messenger/genetics/*metabolism, Synapses/genetics/metabolism, Animals, Male, Rats, Rats, Sprague-Dawley, Dendrites/genetics/*metabolism, Dentate Gyrus/cytology/*metabolism, Nerve Tissue Proteins/genetics/*metabolism, Neuronal Plasticity/physiology, Poly(A)-Binding Proteins/genetics/*metabolism, Protein Biosynthesis/*physiology, Protein Isoforms/genetics/metabolism, RNA, Messenger/genetics/*metabolism, Synapses/genetics/metabolism",
author = "Hatmone Miroci and Claudia Schob and Stefan Kindler and Janin {\"O}lschl{\"a}ger-Sch{\"u}tt and Susanne Fehr and Tassilo Jungenitz and Schwarzacher, {Stephan W} and Claudia Bagni and Evita Mohr",
year = "2012",
language = "English",
volume = "287",
pages = "1322--1334",
journal = "J BIOL CHEM",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.

AU - Miroci, Hatmone

AU - Schob, Claudia

AU - Kindler, Stefan

AU - Ölschläger-Schütt, Janin

AU - Fehr, Susanne

AU - Jungenitz, Tassilo

AU - Schwarzacher, Stephan W

AU - Bagni, Claudia

AU - Mohr, Evita

PY - 2012

Y1 - 2012

N2 - The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein complexes, plays a crucial role in the control of mRNA translation rates, stability, and subcellular targeting. In this study we identify RING zinc finger protein Makorin 1 (MKRN1), a bona fide RNA-binding protein, as a binding partner of PABP that interacts with PABP in an RNA-independent manner. In rat brain, a so far uncharacterized short MKRN1 isoform, MKRN1-short, predominates and is detected in forebrain nerve cells. In neuronal dendrites, MKRN1-short co-localizes with PABP in granule-like structures, which are morphological correlates of sites of mRNA metabolism. Moreover, in primary rat neurons MKRN1-short associates with dendritically localized mRNAs. When tethered to a reporter mRNA, MKRN1-short significantly enhances reporter protein synthesis. Furthermore, after induction of synaptic plasticity via electrical stimulation of the perforant path in vivo, MKRN1-short specifically accumulates in the activated dendritic lamina, the middle molecular layer of the hippocampal dentate gyrus. Collectively, these data indicate that in mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses.

AB - The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein complexes, plays a crucial role in the control of mRNA translation rates, stability, and subcellular targeting. In this study we identify RING zinc finger protein Makorin 1 (MKRN1), a bona fide RNA-binding protein, as a binding partner of PABP that interacts with PABP in an RNA-independent manner. In rat brain, a so far uncharacterized short MKRN1 isoform, MKRN1-short, predominates and is detected in forebrain nerve cells. In neuronal dendrites, MKRN1-short co-localizes with PABP in granule-like structures, which are morphological correlates of sites of mRNA metabolism. Moreover, in primary rat neurons MKRN1-short associates with dendritically localized mRNAs. When tethered to a reporter mRNA, MKRN1-short significantly enhances reporter protein synthesis. Furthermore, after induction of synaptic plasticity via electrical stimulation of the perforant path in vivo, MKRN1-short specifically accumulates in the activated dendritic lamina, the middle molecular layer of the hippocampal dentate gyrus. Collectively, these data indicate that in mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses.

KW - Animals

KW - Male

KW - Rats

KW - Rats, Sprague-Dawley

KW - Dendrites/genetics/metabolism

KW - Dentate Gyrus/cytology/metabolism

KW - Nerve Tissue Proteins/genetics/metabolism

KW - Neuronal Plasticity/physiology

KW - Poly(A)-Binding Proteins/genetics/metabolism

KW - Protein Biosynthesis/physiology

KW - Protein Isoforms/genetics/metabolism

KW - RNA, Messenger/genetics/metabolism

KW - Synapses/genetics/metabolism

KW - Animals

KW - Male

KW - Rats

KW - Rats, Sprague-Dawley

KW - Dendrites/genetics/metabolism

KW - Dentate Gyrus/cytology/metabolism

KW - Nerve Tissue Proteins/genetics/metabolism

KW - Neuronal Plasticity/physiology

KW - Poly(A)-Binding Proteins/genetics/metabolism

KW - Protein Biosynthesis/physiology

KW - Protein Isoforms/genetics/metabolism

KW - RNA, Messenger/genetics/metabolism

KW - Synapses/genetics/metabolism

M3 - SCORING: Journal article

VL - 287

SP - 1322

EP - 1334

JO - J BIOL CHEM

JF - J BIOL CHEM

SN - 0021-9258

IS - 2

M1 - 2

ER -