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Maintaining proteostasis under mechanical stress

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Maintaining proteostasis under mechanical stress. / Höhfeld, Jörg; Benzing, Thomas; Bloch, Wilhelm; Fürst, Dieter O; Gehlert, Sebastian; Hesse, Michael; Hoffmann, Bernd; Hoppe, Thorsten; Huesgen, Pitter F; Köhn, Maja; Kolanus, Waldemar; Merkel, Rudolf; Niessen, Carien M; Pokrzywa, Wojciech; Rinschen, Markus M; Wachten, Dagmar; Warscheid, Bettina.

in: EMBO REP, Jahrgang 22, Nr. 8, e52507, 04.08.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Höhfeld, J, Benzing, T, Bloch, W, Fürst, DO, Gehlert, S, Hesse, M, Hoffmann, B, Hoppe, T, Huesgen, PF, Köhn, M, Kolanus, W, Merkel, R, Niessen, CM, Pokrzywa, W, Rinschen, MM, Wachten, D & Warscheid, B 2021, 'Maintaining proteostasis under mechanical stress', EMBO REP, Jg. 22, Nr. 8, e52507. https://doi.org/10.15252/embr.202152507

APA

Höhfeld, J., Benzing, T., Bloch, W., Fürst, D. O., Gehlert, S., Hesse, M., Hoffmann, B., Hoppe, T., Huesgen, P. F., Köhn, M., Kolanus, W., Merkel, R., Niessen, C. M., Pokrzywa, W., Rinschen, M. M., Wachten, D., & Warscheid, B. (2021). Maintaining proteostasis under mechanical stress. EMBO REP, 22(8), [e52507]. https://doi.org/10.15252/embr.202152507

Vancouver

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M et al. Maintaining proteostasis under mechanical stress. EMBO REP. 2021 Aug 4;22(8). e52507. https://doi.org/10.15252/embr.202152507

Bibtex

@article{8d73653538134ed9901449a1f1011c83,
title = "Maintaining proteostasis under mechanical stress",
abstract = "Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.",
keywords = "Cell Survival, Protein Folding, Proteome/metabolism, Proteostasis, Stress, Mechanical",
author = "J{\"o}rg H{\"o}hfeld and Thomas Benzing and Wilhelm Bloch and F{\"u}rst, {Dieter O} and Sebastian Gehlert and Michael Hesse and Bernd Hoffmann and Thorsten Hoppe and Huesgen, {Pitter F} and Maja K{\"o}hn and Waldemar Kolanus and Rudolf Merkel and Niessen, {Carien M} and Wojciech Pokrzywa and Rinschen, {Markus M} and Dagmar Wachten and Bettina Warscheid",
note = "{\textcopyright} 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.",
year = "2021",
month = aug,
day = "4",
doi = "10.15252/embr.202152507",
language = "English",
volume = "22",
journal = "EMBO REP",
issn = "1469-221X",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Maintaining proteostasis under mechanical stress

AU - Höhfeld, Jörg

AU - Benzing, Thomas

AU - Bloch, Wilhelm

AU - Fürst, Dieter O

AU - Gehlert, Sebastian

AU - Hesse, Michael

AU - Hoffmann, Bernd

AU - Hoppe, Thorsten

AU - Huesgen, Pitter F

AU - Köhn, Maja

AU - Kolanus, Waldemar

AU - Merkel, Rudolf

AU - Niessen, Carien M

AU - Pokrzywa, Wojciech

AU - Rinschen, Markus M

AU - Wachten, Dagmar

AU - Warscheid, Bettina

N1 - © 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

PY - 2021/8/4

Y1 - 2021/8/4

N2 - Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.

AB - Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.

KW - Cell Survival

KW - Protein Folding

KW - Proteome/metabolism

KW - Proteostasis

KW - Stress, Mechanical

U2 - 10.15252/embr.202152507

DO - 10.15252/embr.202152507

M3 - SCORING: Review article

C2 - 34309183

VL - 22

JO - EMBO REP

JF - EMBO REP

SN - 1469-221X

IS - 8

M1 - e52507

ER -