PortalPublikationenMagnitude of Type I Interferon Responses by Plasmacytoid Den...

Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy

Standard

Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy. / Thiele, Rebecca-Jo; Grünhagel, Benjamin; Muenchhoff, Maximilian; Pujantell-Graell, Maria; Jocham, Linda; Düsedau, Arne; Hennesen, Jana; Hildebrandt, Heike; Hagen, Sven Hendrik; Sandfort, Deborah; Bunders, Madeleine J; Keppler, Oliver T; Hoffmann, Christian; Altfeld, Marcus.

in: J INFECT DIS, Jahrgang 229, Nr. 6, 14.06.2024, S. 1781-1785.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Thiele, R-J, Grünhagel, B, Muenchhoff, M, Pujantell-Graell, M, Jocham, L, Düsedau, A, Hennesen, J, Hildebrandt, H, Hagen, SH, Sandfort, D, Bunders, MJ, Keppler, OT, Hoffmann, C & Altfeld, M 2024, 'Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy', J INFECT DIS, Jg. 229, Nr. 6, S. 1781-1785. https://doi.org/10.1093/infdis/jiae013

APA

Thiele, R-J., Grünhagel, B., Muenchhoff, M., Pujantell-Graell, M., Jocham, L., Düsedau, A., Hennesen, J., Hildebrandt, H., Hagen, S. H., Sandfort, D., Bunders, M. J., Keppler, O. T., Hoffmann, C., & Altfeld, M. (2024). Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy. J INFECT DIS, 229(6), 1781-1785. https://doi.org/10.1093/infdis/jiae013

Vancouver

Thiele R-J, Grünhagel B, Muenchhoff M, Pujantell-Graell M, Jocham L, Düsedau A et al. Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy. J INFECT DIS. 2024 Jun 14;229(6):1781-1785. https://doi.org/10.1093/infdis/jiae013

Bibtex

@article{537da16e1e1844ea9e9d5eec642c33cd,
title = "Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy",
abstract = "Human immunodeficiency virus type 1 (HIV-1) disease manifestations differ between cisgender women and men, including better control of viral replication during primary infection and less frequent residual HIV-1 replication on antiretroviral therapy (ART) in cisgender women with HIV-1 (WWH). Investigating plasmacytoid dendritic cell (pDC) functions and HIV-1 reservoir sizes in 20 WWH on stable ART, we observed inverse correlations between interferon-α and tumor necrosis factor responses of pDCs to Toll-like receptor 7/8 stimulation and intact/total proviral HIV-1 DNA levels. Additionally, ISG15 mRNA levels in peripheral blood mononuclear cells correlated with cytokine responses of pDCs. These findings demonstrate an association between higher type I interferon responses and lower HIV-1 reservoir sizes in WWH on ART, warranting studies to identify the underlying mechanisms.",
keywords = "Humans, Dendritic Cells/immunology, HIV-1, Female, HIV Infections/drug therapy, Adult, Toll-Like Receptor 7, Interferon Type I, Middle Aged, Virus Replication/drug effects, Viral Load, Anti-Retroviral Agents/therapeutic use, Leukocytes, Mononuclear/virology",
author = "Rebecca-Jo Thiele and Benjamin Gr{\"u}nhagel and Maximilian Muenchhoff and Maria Pujantell-Graell and Linda Jocham and Arne D{\"u}sedau and Jana Hennesen and Heike Hildebrandt and Hagen, {Sven Hendrik} and Deborah Sandfort and Bunders, {Madeleine J} and Keppler, {Oliver T} and Christian Hoffmann and Marcus Altfeld",
note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2024",
month = jun,
day = "14",
doi = "10.1093/infdis/jiae013",
language = "English",
volume = "229",
pages = "1781--1785",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy

AU - Thiele, Rebecca-Jo

AU - Grünhagel, Benjamin

AU - Muenchhoff, Maximilian

AU - Pujantell-Graell, Maria

AU - Jocham, Linda

AU - Düsedau, Arne

AU - Hennesen, Jana

AU - Hildebrandt, Heike

AU - Hagen, Sven Hendrik

AU - Sandfort, Deborah

AU - Bunders, Madeleine J

AU - Keppler, Oliver T

AU - Hoffmann, Christian

AU - Altfeld, Marcus

N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2024/6/14

Y1 - 2024/6/14

N2 - Human immunodeficiency virus type 1 (HIV-1) disease manifestations differ between cisgender women and men, including better control of viral replication during primary infection and less frequent residual HIV-1 replication on antiretroviral therapy (ART) in cisgender women with HIV-1 (WWH). Investigating plasmacytoid dendritic cell (pDC) functions and HIV-1 reservoir sizes in 20 WWH on stable ART, we observed inverse correlations between interferon-α and tumor necrosis factor responses of pDCs to Toll-like receptor 7/8 stimulation and intact/total proviral HIV-1 DNA levels. Additionally, ISG15 mRNA levels in peripheral blood mononuclear cells correlated with cytokine responses of pDCs. These findings demonstrate an association between higher type I interferon responses and lower HIV-1 reservoir sizes in WWH on ART, warranting studies to identify the underlying mechanisms.

AB - Human immunodeficiency virus type 1 (HIV-1) disease manifestations differ between cisgender women and men, including better control of viral replication during primary infection and less frequent residual HIV-1 replication on antiretroviral therapy (ART) in cisgender women with HIV-1 (WWH). Investigating plasmacytoid dendritic cell (pDC) functions and HIV-1 reservoir sizes in 20 WWH on stable ART, we observed inverse correlations between interferon-α and tumor necrosis factor responses of pDCs to Toll-like receptor 7/8 stimulation and intact/total proviral HIV-1 DNA levels. Additionally, ISG15 mRNA levels in peripheral blood mononuclear cells correlated with cytokine responses of pDCs. These findings demonstrate an association between higher type I interferon responses and lower HIV-1 reservoir sizes in WWH on ART, warranting studies to identify the underlying mechanisms.

KW - Humans

KW - Dendritic Cells/immunology

KW - HIV-1

KW - Female

KW - HIV Infections/drug therapy

KW - Adult

KW - Toll-Like Receptor 7

KW - Interferon Type I

KW - Middle Aged

KW - Virus Replication/drug effects

KW - Viral Load

KW - Anti-Retroviral Agents/therapeutic use

KW - Leukocytes, Mononuclear/virology

U2 - 10.1093/infdis/jiae013

DO - 10.1093/infdis/jiae013

M3 - SCORING: Journal article

C2 - 38385222

VL - 229

SP - 1781

EP - 1785

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 6

ER -