Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress.
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Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress. / Eckart, Cindy; Kaufmann, Jörn; Kanowski, Martin; Tempelmann, Claus; Hinrichs, Hermann; Elbert, Thomas; Heinze, Hans-Jochen; Kolassa, Iris-Tatjana.
in: PSYCHOPHYSIOLOGY, Jahrgang 49, Nr. 2, 2, 2012, S. 261-270.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress.
AU - Eckart, Cindy
AU - Kaufmann, Jörn
AU - Kanowski, Martin
AU - Tempelmann, Claus
AU - Hinrichs, Hermann
AU - Elbert, Thomas
AU - Heinze, Hans-Jochen
AU - Kolassa, Iris-Tatjana
PY - 2012
Y1 - 2012
N2 - Severe and chronic stress affects the hippocampus, especially during development. However, studies concerning structural alterations of the hippocampus yielded a rather inconsistent picture. Moreover, further anxiety-relevant brain regions, such as the insula, might be implicated in the pathophysiology of posttraumatic stress disorder (PTSD). We combined magnetic resonance (MR) volumetric and spectroscopic analyses of hippocampus and insula in highly traumatized refugees without a history of alcohol/substance abuse or other comorbid diseases. No PTSD-related difference was apparent in the volumes or neurometabolite levels of bilateral hippocampus or insula. However, an association between left hippocampal N-acetyl-aspartate (NAA) and adverse childhood experiences indicated a potential detrimental effect of the early environment on hippocampal integrity. Our results add to increasing evidence that PTSD-related, morphological alterations in the hippocampus are a consequence of early adversity or may result from other factors, such as extensive use of alcohol.
AB - Severe and chronic stress affects the hippocampus, especially during development. However, studies concerning structural alterations of the hippocampus yielded a rather inconsistent picture. Moreover, further anxiety-relevant brain regions, such as the insula, might be implicated in the pathophysiology of posttraumatic stress disorder (PTSD). We combined magnetic resonance (MR) volumetric and spectroscopic analyses of hippocampus and insula in highly traumatized refugees without a history of alcohol/substance abuse or other comorbid diseases. No PTSD-related difference was apparent in the volumes or neurometabolite levels of bilateral hippocampus or insula. However, an association between left hippocampal N-acetyl-aspartate (NAA) and adverse childhood experiences indicated a potential detrimental effect of the early environment on hippocampal integrity. Our results add to increasing evidence that PTSD-related, morphological alterations in the hippocampus are a consequence of early adversity or may result from other factors, such as extensive use of alcohol.
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Case-Control Studies
KW - Magnetic Resonance Spectroscopy
KW - Cerebral Cortex/pathology
KW - Hippocampus/pathology
KW - Refugees/psychology
KW - Stress Disorders, Post-Traumatic/pathology
KW - Stress, Psychological/pathology
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Magnetic Resonance Imaging
KW - Case-Control Studies
KW - Magnetic Resonance Spectroscopy
KW - Cerebral Cortex/pathology
KW - Hippocampus/pathology
KW - Refugees/psychology
KW - Stress Disorders, Post-Traumatic/pathology
KW - Stress, Psychological/pathology
M3 - SCORING: Journal article
VL - 49
SP - 261
EP - 270
JO - PSYCHOPHYSIOLOGY
JF - PSYCHOPHYSIOLOGY
SN - 0048-5772
IS - 2
M1 - 2
ER -
