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Lysosomal enzyme trafficking

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Lysosomal enzyme trafficking : from molecular mechanisms to human diseases. / Braulke, Thomas; Carette, Jan E; Palm, Wilhelm.

in: TRENDS CELL BIOL, Jahrgang 34, Nr. 3, 03.2024, S. 198-210.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Braulke, T, Carette, JE & Palm, W 2024, 'Lysosomal enzyme trafficking: from molecular mechanisms to human diseases', TRENDS CELL BIOL, Jg. 34, Nr. 3, S. 198-210. https://doi.org/10.1016/j.tcb.2023.06.005

APA

Braulke, T., Carette, J. E., & Palm, W. (2024). Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. TRENDS CELL BIOL, 34(3), 198-210. https://doi.org/10.1016/j.tcb.2023.06.005

Vancouver

Braulke T, Carette JE, Palm W. Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. TRENDS CELL BIOL. 2024 Mär;34(3):198-210. https://doi.org/10.1016/j.tcb.2023.06.005

Bibtex

@article{1224db7bc43848f08c5dca1d402314f4,
title = "Lysosomal enzyme trafficking: from molecular mechanisms to human diseases",
abstract = "Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.",
author = "Thomas Braulke and Carette, {Jan E} and Wilhelm Palm",
year = "2024",
month = mar,
doi = "10.1016/j.tcb.2023.06.005",
language = "English",
volume = "34",
pages = "198--210",
journal = "TRENDS CELL BIOL",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "3",

}

RIS

TY - JOUR

T1 - Lysosomal enzyme trafficking

T2 - from molecular mechanisms to human diseases

AU - Braulke, Thomas

AU - Carette, Jan E

AU - Palm, Wilhelm

PY - 2024/3

Y1 - 2024/3

N2 - Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.

AB - Lysosomes degrade and recycle macromolecules that are delivered through the biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of macromolecules is catalyzed by about 70 soluble enzymes that are transported from the Golgi apparatus to lysosomes in a mannose 6-phosphate (M6P)-dependent process. The molecular machinery that generates M6P tags for receptor-mediated targeting of lysosomal enzymes was thought to be understood in detail. However, recent studies on the M6P pathway have identified a previously uncharacterized core component, yielded structural insights in known components, and uncovered functions in various human diseases. Here we review molecular mechanisms of lysosomal enzyme trafficking and discuss its relevance for rare lysosomal disorders, cancer, and viral infection.

U2 - 10.1016/j.tcb.2023.06.005

DO - 10.1016/j.tcb.2023.06.005

M3 - SCORING: Review article

C2 - 37474375

VL - 34

SP - 198

EP - 210

JO - TRENDS CELL BIOL

JF - TRENDS CELL BIOL

SN - 0962-8924

IS - 3

ER -