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Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

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Lymph node retrieval in colorectal cancer: determining factors and prognostic significance. / Betge, Johannes; Harbaum, Lars; Pollheimer, Marion J; Lindtner, Richard A; Kornprat, Peter; Ebert, Matthias P; Langner, Cord.

in: INT J COLORECTAL DIS, Jahrgang 32, Nr. 7, 07.2017, S. 991-998.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Betge, J, Harbaum, L, Pollheimer, MJ, Lindtner, RA, Kornprat, P, Ebert, MP & Langner, C 2017, 'Lymph node retrieval in colorectal cancer: determining factors and prognostic significance', INT J COLORECTAL DIS, Jg. 32, Nr. 7, S. 991-998. https://doi.org/10.1007/s00384-017-2778-8

APA

Betge, J., Harbaum, L., Pollheimer, M. J., Lindtner, R. A., Kornprat, P., Ebert, M. P., & Langner, C. (2017). Lymph node retrieval in colorectal cancer: determining factors and prognostic significance. INT J COLORECTAL DIS, 32(7), 991-998. https://doi.org/10.1007/s00384-017-2778-8

Vancouver

Betge J, Harbaum L, Pollheimer MJ, Lindtner RA, Kornprat P, Ebert MP et al. Lymph node retrieval in colorectal cancer: determining factors and prognostic significance. INT J COLORECTAL DIS. 2017 Jul;32(7):991-998. https://doi.org/10.1007/s00384-017-2778-8

Bibtex

@article{67af2fd90d3e4a70bb97c5b9addd58e7,
title = "Lymph node retrieval in colorectal cancer: determining factors and prognostic significance",
abstract = "PURPOSE: The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC).METHODS: The number of retrieved lymph nodes was analyzed in 381 CRC specimens. Lymph node count was related to different clinicopathological variables by binary logistic regression. Progression-free survival (PFS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method and Cox regression models.RESULTS: The median number of retrieved lymph nodes was 20 (mean 21 ± 10, range 1-65) in right-sided, 13 (16 ± 10, 1-66) in left-sided, and 15 (18 ± 11, 3-64) in rectal tumors. The number of retrieved lymph nodes was independently associated with T-classification (p < 0.001), N-classification (p = 0.014), and tumor size (p = 0.005) as well as right-sided tumor location (p = 0.012). There was no association with age, sex, tumor grade, mismatch-repair status, and lymph or blood vessel invasion. The longer the surgical specimen, the higher were the numbers of retrieved and positive lymph nodes (p < 0.001, respectively). In patients with locally advanced (T3/T4) tumors (n = 283), analysis of more than 12 lymph nodes was independently associated with PFS (HR = 0.63, p = 0.025) and CSS (HR = 0.54, p = 0.004). In the subset of T3/T4 N0 patients (n = 130), analysis of more than 12 lymph nodes similarly proved to be an independent predictor of outcome (PFS, HR = 0.48, p = 0.046; OS, HR = 0.41, p = 0.026).CONCLUSION: The number of retrieved lymph nodes is associated with higher tumor stage, tumor size, and right-sided location. Low lymph node count indicates adverse outcome in patients with locally advanced (T3/T4) disease.",
keywords = "Journal Article",
author = "Johannes Betge and Lars Harbaum and Pollheimer, {Marion J} and Lindtner, {Richard A} and Peter Kornprat and Ebert, {Matthias P} and Cord Langner",
year = "2017",
month = jul,
doi = "10.1007/s00384-017-2778-8",
language = "English",
volume = "32",
pages = "991--998",
journal = "INT J COLORECTAL DIS",
issn = "0179-1958",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

AU - Betge, Johannes

AU - Harbaum, Lars

AU - Pollheimer, Marion J

AU - Lindtner, Richard A

AU - Kornprat, Peter

AU - Ebert, Matthias P

AU - Langner, Cord

PY - 2017/7

Y1 - 2017/7

N2 - PURPOSE: The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC).METHODS: The number of retrieved lymph nodes was analyzed in 381 CRC specimens. Lymph node count was related to different clinicopathological variables by binary logistic regression. Progression-free survival (PFS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method and Cox regression models.RESULTS: The median number of retrieved lymph nodes was 20 (mean 21 ± 10, range 1-65) in right-sided, 13 (16 ± 10, 1-66) in left-sided, and 15 (18 ± 11, 3-64) in rectal tumors. The number of retrieved lymph nodes was independently associated with T-classification (p < 0.001), N-classification (p = 0.014), and tumor size (p = 0.005) as well as right-sided tumor location (p = 0.012). There was no association with age, sex, tumor grade, mismatch-repair status, and lymph or blood vessel invasion. The longer the surgical specimen, the higher were the numbers of retrieved and positive lymph nodes (p < 0.001, respectively). In patients with locally advanced (T3/T4) tumors (n = 283), analysis of more than 12 lymph nodes was independently associated with PFS (HR = 0.63, p = 0.025) and CSS (HR = 0.54, p = 0.004). In the subset of T3/T4 N0 patients (n = 130), analysis of more than 12 lymph nodes similarly proved to be an independent predictor of outcome (PFS, HR = 0.48, p = 0.046; OS, HR = 0.41, p = 0.026).CONCLUSION: The number of retrieved lymph nodes is associated with higher tumor stage, tumor size, and right-sided location. Low lymph node count indicates adverse outcome in patients with locally advanced (T3/T4) disease.

AB - PURPOSE: The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC).METHODS: The number of retrieved lymph nodes was analyzed in 381 CRC specimens. Lymph node count was related to different clinicopathological variables by binary logistic regression. Progression-free survival (PFS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method and Cox regression models.RESULTS: The median number of retrieved lymph nodes was 20 (mean 21 ± 10, range 1-65) in right-sided, 13 (16 ± 10, 1-66) in left-sided, and 15 (18 ± 11, 3-64) in rectal tumors. The number of retrieved lymph nodes was independently associated with T-classification (p < 0.001), N-classification (p = 0.014), and tumor size (p = 0.005) as well as right-sided tumor location (p = 0.012). There was no association with age, sex, tumor grade, mismatch-repair status, and lymph or blood vessel invasion. The longer the surgical specimen, the higher were the numbers of retrieved and positive lymph nodes (p < 0.001, respectively). In patients with locally advanced (T3/T4) tumors (n = 283), analysis of more than 12 lymph nodes was independently associated with PFS (HR = 0.63, p = 0.025) and CSS (HR = 0.54, p = 0.004). In the subset of T3/T4 N0 patients (n = 130), analysis of more than 12 lymph nodes similarly proved to be an independent predictor of outcome (PFS, HR = 0.48, p = 0.046; OS, HR = 0.41, p = 0.026).CONCLUSION: The number of retrieved lymph nodes is associated with higher tumor stage, tumor size, and right-sided location. Low lymph node count indicates adverse outcome in patients with locally advanced (T3/T4) disease.

KW - Journal Article

U2 - 10.1007/s00384-017-2778-8

DO - 10.1007/s00384-017-2778-8

M3 - SCORING: Journal article

C2 - 28210855

VL - 32

SP - 991

EP - 998

JO - INT J COLORECTAL DIS

JF - INT J COLORECTAL DIS

SN - 0179-1958

IS - 7

ER -