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Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients

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Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients. / Bramlage, Carsten P; Armstrong, Victor W; Zapf, Antonia; Bramlage, Peter; Mueller, Gerhard A; Koziolek, Michael J.

in: THER APHER DIAL, Jahrgang 14, Nr. 2, 04.2010, S. 136-142.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bramlage, CP, Armstrong, VW, Zapf, A, Bramlage, P, Mueller, GA & Koziolek, MJ 2010, 'Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients', THER APHER DIAL, Jg. 14, Nr. 2, S. 136-142. https://doi.org/10.1111/j.1744-9987.2009.00715.x

APA

Bramlage, C. P., Armstrong, V. W., Zapf, A., Bramlage, P., Mueller, G. A., & Koziolek, M. J. (2010). Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients. THER APHER DIAL, 14(2), 136-142. https://doi.org/10.1111/j.1744-9987.2009.00715.x

Vancouver

Bramlage CP, Armstrong VW, Zapf A, Bramlage P, Mueller GA, Koziolek MJ. Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients. THER APHER DIAL. 2010 Apr;14(2):136-142. https://doi.org/10.1111/j.1744-9987.2009.00715.x

Bibtex

@article{ba8c7169b1724bd2a30708160334a965,
title = "Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients",
abstract = "Clinical observations revealed an increased prevalence of iron deficiency anemia without chronic bleeding in patients treated with serial low-density lipoprotein (LDL) apheresis. Since several different proteins are adsorbed by LDL apheresis beside pro-atherogenic lipoproteins, we examined the modification of the full blood count, plasma iron, vitamin B12, folic acid, and hemolysis by LDL apheresis. Nineteen patients (55 (50-59) years, 4 female, 15 male) undergoing chronic LDL apheresis due to mixed dyslipidemia (N = 17), homozygous familiar hypercholesterolemia (N = 1) or isolated elevated lipoprotein(a) (N = 1) were included in this study. They were treated with direct adsorption of lipoproteins (DALI; N = 6), heparin-induced LDL-precipitation (HELP; N = 7) or double filtration plasmapheresis (DFPP; N = 6). The patients' full blood count, iron metabolism (plasma iron, ferritin, transferrin, transferrin saturation), vitamins involved in erythropoiesis (vitamin B12 and folic acid), and markers of hemolysis (haptoglobin and free hemoglobin) were analyzed directly before and after LDL apheresis. A single LDL apheresis session significantly decreased the levels (reduction in the median [25(th)-75(th) percentiles] of: ferritin 9.8 [1.3-18] %; P = 0.004), transferrin (12.1 [10.0-15.96] %; P = 0.0005), and vitamin B12 (17.8 [16.2-20.8] %; P = 0.0005). Thereby, transferrin and vitamin B12 were decreased in all (N = 19) and ferritin in 74% (N = 14) of the patients. Twelve out of 19 patients (63.2%) had mild anemia despite iron administration in 14 out of 19 patients (73.7%). LDL apheresis had no significant influence on full blood count, plasma iron, transferrin saturation, folic acid, or hemolysis. Similar changes were observed in all LDL apheresis methods used. LDL apheresis significantly decreases ferritin, transferrin, and vitamin B12, suggesting an influence of serial LDL apheresis on erythropoiesis.",
keywords = "Anemia, Blood Component Removal, Dyslipidemias, Erythropoiesis, Female, Ferritins, Filtration, Heparin, Humans, Hyperlipoproteinemia Type II, Lipoprotein(a), Lipoproteins, LDL, Male, Middle Aged, Plasmapheresis, Transferrin, Vitamin B 12, Comparative Study, Controlled Clinical Trial, Journal Article",
author = "Bramlage, {Carsten P} and Armstrong, {Victor W} and Antonia Zapf and Peter Bramlage and Mueller, {Gerhard A} and Koziolek, {Michael J}",
year = "2010",
month = apr,
doi = "10.1111/j.1744-9987.2009.00715.x",
language = "English",
volume = "14",
pages = "136--142",
journal = "THER APHER DIAL",
issn = "1744-9979",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients

AU - Bramlage, Carsten P

AU - Armstrong, Victor W

AU - Zapf, Antonia

AU - Bramlage, Peter

AU - Mueller, Gerhard A

AU - Koziolek, Michael J

PY - 2010/4

Y1 - 2010/4

N2 - Clinical observations revealed an increased prevalence of iron deficiency anemia without chronic bleeding in patients treated with serial low-density lipoprotein (LDL) apheresis. Since several different proteins are adsorbed by LDL apheresis beside pro-atherogenic lipoproteins, we examined the modification of the full blood count, plasma iron, vitamin B12, folic acid, and hemolysis by LDL apheresis. Nineteen patients (55 (50-59) years, 4 female, 15 male) undergoing chronic LDL apheresis due to mixed dyslipidemia (N = 17), homozygous familiar hypercholesterolemia (N = 1) or isolated elevated lipoprotein(a) (N = 1) were included in this study. They were treated with direct adsorption of lipoproteins (DALI; N = 6), heparin-induced LDL-precipitation (HELP; N = 7) or double filtration plasmapheresis (DFPP; N = 6). The patients' full blood count, iron metabolism (plasma iron, ferritin, transferrin, transferrin saturation), vitamins involved in erythropoiesis (vitamin B12 and folic acid), and markers of hemolysis (haptoglobin and free hemoglobin) were analyzed directly before and after LDL apheresis. A single LDL apheresis session significantly decreased the levels (reduction in the median [25(th)-75(th) percentiles] of: ferritin 9.8 [1.3-18] %; P = 0.004), transferrin (12.1 [10.0-15.96] %; P = 0.0005), and vitamin B12 (17.8 [16.2-20.8] %; P = 0.0005). Thereby, transferrin and vitamin B12 were decreased in all (N = 19) and ferritin in 74% (N = 14) of the patients. Twelve out of 19 patients (63.2%) had mild anemia despite iron administration in 14 out of 19 patients (73.7%). LDL apheresis had no significant influence on full blood count, plasma iron, transferrin saturation, folic acid, or hemolysis. Similar changes were observed in all LDL apheresis methods used. LDL apheresis significantly decreases ferritin, transferrin, and vitamin B12, suggesting an influence of serial LDL apheresis on erythropoiesis.

AB - Clinical observations revealed an increased prevalence of iron deficiency anemia without chronic bleeding in patients treated with serial low-density lipoprotein (LDL) apheresis. Since several different proteins are adsorbed by LDL apheresis beside pro-atherogenic lipoproteins, we examined the modification of the full blood count, plasma iron, vitamin B12, folic acid, and hemolysis by LDL apheresis. Nineteen patients (55 (50-59) years, 4 female, 15 male) undergoing chronic LDL apheresis due to mixed dyslipidemia (N = 17), homozygous familiar hypercholesterolemia (N = 1) or isolated elevated lipoprotein(a) (N = 1) were included in this study. They were treated with direct adsorption of lipoproteins (DALI; N = 6), heparin-induced LDL-precipitation (HELP; N = 7) or double filtration plasmapheresis (DFPP; N = 6). The patients' full blood count, iron metabolism (plasma iron, ferritin, transferrin, transferrin saturation), vitamins involved in erythropoiesis (vitamin B12 and folic acid), and markers of hemolysis (haptoglobin and free hemoglobin) were analyzed directly before and after LDL apheresis. A single LDL apheresis session significantly decreased the levels (reduction in the median [25(th)-75(th) percentiles] of: ferritin 9.8 [1.3-18] %; P = 0.004), transferrin (12.1 [10.0-15.96] %; P = 0.0005), and vitamin B12 (17.8 [16.2-20.8] %; P = 0.0005). Thereby, transferrin and vitamin B12 were decreased in all (N = 19) and ferritin in 74% (N = 14) of the patients. Twelve out of 19 patients (63.2%) had mild anemia despite iron administration in 14 out of 19 patients (73.7%). LDL apheresis had no significant influence on full blood count, plasma iron, transferrin saturation, folic acid, or hemolysis. Similar changes were observed in all LDL apheresis methods used. LDL apheresis significantly decreases ferritin, transferrin, and vitamin B12, suggesting an influence of serial LDL apheresis on erythropoiesis.

KW - Anemia

KW - Blood Component Removal

KW - Dyslipidemias

KW - Erythropoiesis

KW - Female

KW - Ferritins

KW - Filtration

KW - Heparin

KW - Humans

KW - Hyperlipoproteinemia Type II

KW - Lipoprotein(a)

KW - Lipoproteins, LDL

KW - Male

KW - Middle Aged

KW - Plasmapheresis

KW - Transferrin

KW - Vitamin B 12

KW - Comparative Study

KW - Controlled Clinical Trial

KW - Journal Article

U2 - 10.1111/j.1744-9987.2009.00715.x

DO - 10.1111/j.1744-9987.2009.00715.x

M3 - SCORING: Journal article

C2 - 20438534

VL - 14

SP - 136

EP - 142

JO - THER APHER DIAL

JF - THER APHER DIAL

SN - 1744-9979

IS - 2

ER -