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Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study

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Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study. / Zeller, Tanja; Schnabel, Renate B; Appelbaum, Sebastian; Ojeda, Francisco; Berisha, Filip; Schulte-Steinberg, Benedict; Brueckmann, Burkhard-Ekkehart; Kuulasmaa, Kari; Jousilahti, Pekka; Blankenberg, Stefan; Palosaari, Tarja; Salomaa, Veikko; Karakas, Mahir.

in: EUR J PREV CARDIOL, Jahrgang 25, Nr. 11, 07.2018, S. 1133-1139.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zeller, T, Schnabel, RB, Appelbaum, S, Ojeda, F, Berisha, F, Schulte-Steinberg, B, Brueckmann, B-E, Kuulasmaa, K, Jousilahti, P, Blankenberg, S, Palosaari, T, Salomaa, V & Karakas, M 2018, 'Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study', EUR J PREV CARDIOL, Jg. 25, Nr. 11, S. 1133-1139. https://doi.org/10.1177/2047487318778346

APA

Zeller, T., Schnabel, R. B., Appelbaum, S., Ojeda, F., Berisha, F., Schulte-Steinberg, B., Brueckmann, B-E., Kuulasmaa, K., Jousilahti, P., Blankenberg, S., Palosaari, T., Salomaa, V., & Karakas, M. (2018). Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study. EUR J PREV CARDIOL, 25(11), 1133-1139. https://doi.org/10.1177/2047487318778346

Vancouver

Zeller T, Schnabel RB, Appelbaum S, Ojeda F, Berisha F, Schulte-Steinberg B et al. Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study. EUR J PREV CARDIOL. 2018 Jul;25(11):1133-1139. https://doi.org/10.1177/2047487318778346

Bibtex

@article{08ff811a895442128bf804e31fb26108,
title = "Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study",
abstract = "Background Atrial fibrillation is the most common serious abnormal heart rhythm, and a frequent cause of ischaemic stroke. Recent experimental studies, mainly in orchiectomised rats, report a relationship between sex hormones and atrial electrophysiology and electroanatomy. We aimed to evaluate whether low testosterone levels are predictive for atrial fibrillation and/or ischaemic stroke in men and women. Design and methods The serum total testosterone levels were measured at baseline in a population cohort of 7892 subjects (3876 male, 4016 female), aged 25-74 years, using a commercially available immunoassay. The main outcome measure was atrial fibrillation or ischaemic stroke, whichever came first. Results During a median follow-up of 13.8 years, a total of 629 subjects (8.0%) suffered from incident atrial fibrillation ( n = 426) and/or ischemic stroke ( n = 276). Cox regression analyses, adjusted for age (used as time-scale), geographical region, total cholesterol (log), high-density lipoprotein-cholesterol (log), hypertension medication, known diabetes, smoking status, waist-hip-ratio, and time of blood drawn, documented differential predictive value of low sex-specific testosterone levels for atrial fibrillation and/or ischaemic stroke, in men and in women: Increasing levels were associated with lower risk in men (hazard ratio per one nmol/l increase 0.98 (95% confidence interval 0.93-1.00); p = 0.049). On the other hand, increasing testosterone levels were associated with higher risk in women (hazard ratio per one nmol/l increase 1.17 (95% confidence interval 1.02-1.36); p = 0.031). Conclusion Our study indicates that low testosterone levels are associated with increased risk of future atrial fibrillation and/or ischaemic stroke in men, while they are protective in women.",
keywords = "Adult, Aged, Atrial Fibrillation/blood, Biomarkers/blood, Brain Ischemia/blood, Electrocardiography, Female, Finland/epidemiology, Follow-Up Studies, Forecasting, Humans, Immunoassay, Incidence, Male, Middle Aged, Population Surveillance/methods, Prospective Studies, Sex Distribution, Sex Factors, Testosterone/blood",
author = "Tanja Zeller and Schnabel, {Renate B} and Sebastian Appelbaum and Francisco Ojeda and Filip Berisha and Benedict Schulte-Steinberg and Burkhard-Ekkehart Brueckmann and Kari Kuulasmaa and Pekka Jousilahti and Stefan Blankenberg and Tarja Palosaari and Veikko Salomaa and Mahir Karakas",
year = "2018",
month = jul,
doi = "10.1177/2047487318778346",
language = "English",
volume = "25",
pages = "1133--1139",
journal = "EUR J PREV CARDIOL",
issn = "2047-4873",
publisher = "SAGE Publications",
number = "11",

}

RIS

TY - JOUR

T1 - Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women - results from the FINRISK study

AU - Zeller, Tanja

AU - Schnabel, Renate B

AU - Appelbaum, Sebastian

AU - Ojeda, Francisco

AU - Berisha, Filip

AU - Schulte-Steinberg, Benedict

AU - Brueckmann, Burkhard-Ekkehart

AU - Kuulasmaa, Kari

AU - Jousilahti, Pekka

AU - Blankenberg, Stefan

AU - Palosaari, Tarja

AU - Salomaa, Veikko

AU - Karakas, Mahir

PY - 2018/7

Y1 - 2018/7

N2 - Background Atrial fibrillation is the most common serious abnormal heart rhythm, and a frequent cause of ischaemic stroke. Recent experimental studies, mainly in orchiectomised rats, report a relationship between sex hormones and atrial electrophysiology and electroanatomy. We aimed to evaluate whether low testosterone levels are predictive for atrial fibrillation and/or ischaemic stroke in men and women. Design and methods The serum total testosterone levels were measured at baseline in a population cohort of 7892 subjects (3876 male, 4016 female), aged 25-74 years, using a commercially available immunoassay. The main outcome measure was atrial fibrillation or ischaemic stroke, whichever came first. Results During a median follow-up of 13.8 years, a total of 629 subjects (8.0%) suffered from incident atrial fibrillation ( n = 426) and/or ischemic stroke ( n = 276). Cox regression analyses, adjusted for age (used as time-scale), geographical region, total cholesterol (log), high-density lipoprotein-cholesterol (log), hypertension medication, known diabetes, smoking status, waist-hip-ratio, and time of blood drawn, documented differential predictive value of low sex-specific testosterone levels for atrial fibrillation and/or ischaemic stroke, in men and in women: Increasing levels were associated with lower risk in men (hazard ratio per one nmol/l increase 0.98 (95% confidence interval 0.93-1.00); p = 0.049). On the other hand, increasing testosterone levels were associated with higher risk in women (hazard ratio per one nmol/l increase 1.17 (95% confidence interval 1.02-1.36); p = 0.031). Conclusion Our study indicates that low testosterone levels are associated with increased risk of future atrial fibrillation and/or ischaemic stroke in men, while they are protective in women.

AB - Background Atrial fibrillation is the most common serious abnormal heart rhythm, and a frequent cause of ischaemic stroke. Recent experimental studies, mainly in orchiectomised rats, report a relationship between sex hormones and atrial electrophysiology and electroanatomy. We aimed to evaluate whether low testosterone levels are predictive for atrial fibrillation and/or ischaemic stroke in men and women. Design and methods The serum total testosterone levels were measured at baseline in a population cohort of 7892 subjects (3876 male, 4016 female), aged 25-74 years, using a commercially available immunoassay. The main outcome measure was atrial fibrillation or ischaemic stroke, whichever came first. Results During a median follow-up of 13.8 years, a total of 629 subjects (8.0%) suffered from incident atrial fibrillation ( n = 426) and/or ischemic stroke ( n = 276). Cox regression analyses, adjusted for age (used as time-scale), geographical region, total cholesterol (log), high-density lipoprotein-cholesterol (log), hypertension medication, known diabetes, smoking status, waist-hip-ratio, and time of blood drawn, documented differential predictive value of low sex-specific testosterone levels for atrial fibrillation and/or ischaemic stroke, in men and in women: Increasing levels were associated with lower risk in men (hazard ratio per one nmol/l increase 0.98 (95% confidence interval 0.93-1.00); p = 0.049). On the other hand, increasing testosterone levels were associated with higher risk in women (hazard ratio per one nmol/l increase 1.17 (95% confidence interval 1.02-1.36); p = 0.031). Conclusion Our study indicates that low testosterone levels are associated with increased risk of future atrial fibrillation and/or ischaemic stroke in men, while they are protective in women.

KW - Adult

KW - Aged

KW - Atrial Fibrillation/blood

KW - Biomarkers/blood

KW - Brain Ischemia/blood

KW - Electrocardiography

KW - Female

KW - Finland/epidemiology

KW - Follow-Up Studies

KW - Forecasting

KW - Humans

KW - Immunoassay

KW - Incidence

KW - Male

KW - Middle Aged

KW - Population Surveillance/methods

KW - Prospective Studies

KW - Sex Distribution

KW - Sex Factors

KW - Testosterone/blood

U2 - 10.1177/2047487318778346

DO - 10.1177/2047487318778346

M3 - SCORING: Journal article

C2 - 29808758

VL - 25

SP - 1133

EP - 1139

JO - EUR J PREV CARDIOL

JF - EUR J PREV CARDIOL

SN - 2047-4873

IS - 11

ER -