Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer.
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Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer. / Minner, Sarah Jane Pauline; Jessen, Birte; Stiedenroth, Lars; Burandt, Eike Christian; Köllermann, Jens; Mirlacher, Martina; Erbersdobler, Andreas; Eichelberg, Christian; Fisch, Margit; Brümmendorf, Tim; Bokemeyer, Carsten; Simon, Ronald; Steuber, Thomas; Graefen, Markus; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten.
in: CLIN CANCER RES, Jahrgang 16, Nr. 5, 5, 2010, S. 1553-1560.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer.
AU - Minner, Sarah Jane Pauline
AU - Jessen, Birte
AU - Stiedenroth, Lars
AU - Burandt, Eike Christian
AU - Köllermann, Jens
AU - Mirlacher, Martina
AU - Erbersdobler, Andreas
AU - Eichelberg, Christian
AU - Fisch, Margit
AU - Brümmendorf, Tim
AU - Bokemeyer, Carsten
AU - Simon, Ronald
AU - Steuber, Thomas
AU - Graefen, Markus
AU - Huland, Hartwig
AU - Sauter, Guido
AU - Schlomm, Thorsten
PY - 2010
Y1 - 2010
N2 - The HER2 oncogene is involved in the biology of many different tumor types and serves as a prognostic marker and a therapeutic target in breast cancer. In contrast to breast cancer, studies on Her2 overexpression and gene amplification in prostate cancer have yielded different results. The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer.
AB - The HER2 oncogene is involved in the biology of many different tumor types and serves as a prognostic marker and a therapeutic target in breast cancer. In contrast to breast cancer, studies on Her2 overexpression and gene amplification in prostate cancer have yielded different results. The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer.
KW - Humans
KW - Male
KW - Aged
KW - Middle Aged
KW - Prostate-Specific Antigen blood
KW - Immunohistochemistry
KW - Prognosis
KW - Up-Regulation
KW - Neoplasm Recurrence, Local genetics
KW - Gene Amplification
KW - In Situ Hybridization, Fluorescence
KW - Prostatic Neoplasms genetics
KW - Receptor, erbB-2 biosynthesis
KW - Tissue Array Analysis
KW - Tumor Markers, Biological analysis
KW - Humans
KW - Male
KW - Aged
KW - Middle Aged
KW - Prostate-Specific Antigen blood
KW - Immunohistochemistry
KW - Prognosis
KW - Up-Regulation
KW - Neoplasm Recurrence, Local genetics
KW - Gene Amplification
KW - In Situ Hybridization, Fluorescence
KW - Prostatic Neoplasms genetics
KW - Receptor, erbB-2 biosynthesis
KW - Tissue Array Analysis
KW - Tumor Markers, Biological analysis
M3 - SCORING: Zeitschriftenaufsatz
VL - 16
SP - 1553
EP - 1560
JO - CLIN CANCER RES
JF - CLIN CANCER RES
SN - 1078-0432
IS - 5
M1 - 5
ER -