Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract.
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Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract. / Eiber, Matthias; Oers, van; Johanna, M M; Zwarthoff, Ellen C; Kwast, van der; Theo, H; Ulrich, Oehler; Helpap, Burkhard; Stoerkel, Stephan; Sauter, Guido; Cheville, John; Sauter, Guido; Wild, Peter J; Stoehr, Robert; Hofstaedter, Ferdinand; Hartmann, Arndt.
in: AM J SURG PATHOL, Jahrgang 31, Nr. 6, 6, 2007, S. 938-946.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract.
AU - Eiber, Matthias
AU - Oers, van
AU - Johanna, M M
AU - Zwarthoff, Ellen C
AU - Kwast, van der
AU - Theo, H
AU - Ulrich, Oehler
AU - Helpap, Burkhard
AU - Stoerkel, Stephan
AU - Sauter, Guido
AU - Cheville, John
AU - Sauter, Guido
AU - Wild, Peter J
AU - Stoehr, Robert
AU - Hofstaedter, Ferdinand
AU - Hartmann, Arndt
PY - 2007
Y1 - 2007
N2 - AIM: Inverted papilloma (IP) of the urinary tract can be difficult to distinguish from noninvasive urothelial carcinoma with prominent inverted growth pattern (invNIUC). Ancillary markers may help to resolve such cases and clarify the reported malignant potential of some IPs. METHODS: Eighty-nine urothelial lesions initially diagnosed as IP were reviewed by 4 experienced urologic pathologists and studied immunohistochemically (Ki67, p53, CK20, MSH2, MLH1, and MSH6). Mutations of the FGFR3 gene, deletions (loss of heterozygosity) of 9p, 9q, and 17p, microsatellite instability, and elevated microsatellite instability at selected tetranucleotides were also analyzed. RESULTS: Considerable interobserver variability in histopathologic diagnoses was noticed. Only 62 (69.7%) initial diagnoses were confirmed by the review pathologists whereas 23 tumors (25.8%) were redefined as invNIUC. Molecular analyses revealed infrequent alterations in IPs, including microsatellite instability (1.8%), elevated microsatellite instability at selected tetranucleotides (13.2%), FGFR3 mutations (9.8%), 9p deletions (3.9%), 9q deletions (13.2%), 17p deletions (5.1%), nuclear p53 accumulation (18.9%), and aberrant immunostaining for MSH2 (5.8%), MLH1 (11.8%), and MSH6 (3.8%). IP and invNIUC differed in FGFR3 mutations and Ki-67 labeling index (P
AB - AIM: Inverted papilloma (IP) of the urinary tract can be difficult to distinguish from noninvasive urothelial carcinoma with prominent inverted growth pattern (invNIUC). Ancillary markers may help to resolve such cases and clarify the reported malignant potential of some IPs. METHODS: Eighty-nine urothelial lesions initially diagnosed as IP were reviewed by 4 experienced urologic pathologists and studied immunohistochemically (Ki67, p53, CK20, MSH2, MLH1, and MSH6). Mutations of the FGFR3 gene, deletions (loss of heterozygosity) of 9p, 9q, and 17p, microsatellite instability, and elevated microsatellite instability at selected tetranucleotides were also analyzed. RESULTS: Considerable interobserver variability in histopathologic diagnoses was noticed. Only 62 (69.7%) initial diagnoses were confirmed by the review pathologists whereas 23 tumors (25.8%) were redefined as invNIUC. Molecular analyses revealed infrequent alterations in IPs, including microsatellite instability (1.8%), elevated microsatellite instability at selected tetranucleotides (13.2%), FGFR3 mutations (9.8%), 9p deletions (3.9%), 9q deletions (13.2%), 17p deletions (5.1%), nuclear p53 accumulation (18.9%), and aberrant immunostaining for MSH2 (5.8%), MLH1 (11.8%), and MSH6 (3.8%). IP and invNIUC differed in FGFR3 mutations and Ki-67 labeling index (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 31
SP - 938
EP - 946
JO - AM J SURG PATHOL
JF - AM J SURG PATHOL
SN - 0147-5185
IS - 6
M1 - 6
ER -
