Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.
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Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. / Laatsch, Alexander; Panteli, Malamatenia; Sornsakrin, Marijke; Hoffzimmer, Britta; Grewal, Thomas; Heeren, Jörg.
in: PLOS ONE, Jahrgang 7, Nr. 1, 1, 2012, S. 29385.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.
AU - Laatsch, Alexander
AU - Panteli, Malamatenia
AU - Sornsakrin, Marijke
AU - Hoffzimmer, Britta
AU - Grewal, Thomas
AU - Heeren, Jörg
PY - 2012
Y1 - 2012
N2 - Lipoprotein receptors from the low density lipoprotein (LDL) receptor family are multifunctional membrane proteins which can efficiently mediate endocytosis and thereby facilitate lipoprotein clearance from the plasma. The biggest member of this family, the LDL receptor-related protein 1 (LRP1), facilitates the hepatic uptake of triglyceride-rich lipoproteins (TRL) via interaction with apolipoprotein E (apoE). In contrast to the classical LDL degradation pathway, TRL disintegrate in peripheral endosomes, and core lipids and apoB are targeted along the endocytic pathway for lysosomal degradation. Notably, TRL-derived apoE remains within recycling endosomes and is then mobilized by high density lipoproteins (HDL) for re-secretion. The aim of this study is to investigate the involvement of LRP1 in the regulation of apoE recycling.
AB - Lipoprotein receptors from the low density lipoprotein (LDL) receptor family are multifunctional membrane proteins which can efficiently mediate endocytosis and thereby facilitate lipoprotein clearance from the plasma. The biggest member of this family, the LDL receptor-related protein 1 (LRP1), facilitates the hepatic uptake of triglyceride-rich lipoproteins (TRL) via interaction with apolipoprotein E (apoE). In contrast to the classical LDL degradation pathway, TRL disintegrate in peripheral endosomes, and core lipids and apoB are targeted along the endocytic pathway for lysosomal degradation. Notably, TRL-derived apoE remains within recycling endosomes and is then mobilized by high density lipoproteins (HDL) for re-secretion. The aim of this study is to investigate the involvement of LRP1 in the regulation of apoE recycling.
KW - Animals
KW - Humans
KW - Cells, Cultured
KW - Mice
KW - Models, Biological
KW - Mice, Transgenic
KW - Transfection
KW - HEK293 Cells
KW - Endosomes/metabolism
KW - Protein Transport/genetics
KW - Apolipoproteins E/metabolism
KW - Cholesterol, HDL/metabolism
KW - Endocytosis/genetics/physiology
KW - Hepatocytes/metabolism/physiology
KW - Low Density Lipoprotein Receptor-Related Protein-1/genetics/metabolism/physiology
KW - Animals
KW - Humans
KW - Cells, Cultured
KW - Mice
KW - Models, Biological
KW - Mice, Transgenic
KW - Transfection
KW - HEK293 Cells
KW - Endosomes/metabolism
KW - Protein Transport/genetics
KW - Apolipoproteins E/metabolism
KW - Cholesterol, HDL/metabolism
KW - Endocytosis/genetics/physiology
KW - Hepatocytes/metabolism/physiology
KW - Low Density Lipoprotein Receptor-Related Protein-1/genetics/metabolism/physiology
U2 - 10.1371/journal.pone.0029385
DO - 10.1371/journal.pone.0029385
M3 - SCORING: Journal article
VL - 7
SP - 29385
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 1
M1 - 1
ER -
