Loss of Heterozygosity
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Loss of Heterozygosity. / Schwarzenbach, Heidi.
Brenner´s Encyclopedia of Genetics. Hrsg. / Stanley Maloy; Kelly Hughes. Band 2e, 4 2. Aufl. Brenner, 2013. S. 271-273.Publikationen: SCORING: Beitrag in Buch/Sammelwerk › SCORING: Beitrag in Sammelwerk › Forschung › Begutachtung
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TY - CHAP
T1 - Loss of Heterozygosity
AU - Schwarzenbach, Heidi
PY - 2013
Y1 - 2013
N2 - Loss of heterozygosity (LOH) is a common form of allelic imbalance by which a heterozygous somatic cell becomes homozygous because one of the two alleles gets lost. This form of chromosome instability is sufficient to provide selective growth advantage and has been recognized as a major cause of tumorigenesis. In 1929, the genetic mechanism of LOH was explained for the first time by studying mutant spots induced by X-rays in Drosophila melanogaster. Later on, the detection of LOH has been used to identify genomic regions that harbor putative tumor suppressor genes and to characterize different tumor types, pathological stages, and progression. This identification has provided important insight into the molecular mechanisms of malignant transformation and may deliver the targets for future therapy. Screening for LOH can be performed at polymorphic markers in tumor tissue and ‘liquid biopsies’ and be a promising diagnostic and prognostic tool.
AB - Loss of heterozygosity (LOH) is a common form of allelic imbalance by which a heterozygous somatic cell becomes homozygous because one of the two alleles gets lost. This form of chromosome instability is sufficient to provide selective growth advantage and has been recognized as a major cause of tumorigenesis. In 1929, the genetic mechanism of LOH was explained for the first time by studying mutant spots induced by X-rays in Drosophila melanogaster. Later on, the detection of LOH has been used to identify genomic regions that harbor putative tumor suppressor genes and to characterize different tumor types, pathological stages, and progression. This identification has provided important insight into the molecular mechanisms of malignant transformation and may deliver the targets for future therapy. Screening for LOH can be performed at polymorphic markers in tumor tissue and ‘liquid biopsies’ and be a promising diagnostic and prognostic tool.
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-0-08-096156-9
VL - 2e, 4
SP - 271
EP - 273
BT - Brenner´s Encyclopedia of Genetics
A2 - Maloy, Stanley
A2 - Hughes, Kelly
PB - Brenner
ER -
