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Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

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Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment. / Rudenko, Andrii; Seo, Jinsoo; Hu, Ji; Su, Susan C.; Calderon de Anda, Froylan; Durak, Omer; Ericsson, Maria; Carlen, Marie; Tsai, Li-Huei.

in: J NEUROSCI, Jahrgang 35, Nr. 6, 11.02.2015, S. 2372-2383.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rudenko, A, Seo, J, Hu, J, Su, SC, Calderon de Anda, F, Durak, O, Ericsson, M, Carlen, M & Tsai, L-H 2015, 'Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment', J NEUROSCI, Jg. 35, Nr. 6, S. 2372-2383.

APA

Rudenko, A., Seo, J., Hu, J., Su, S. C., Calderon de Anda, F., Durak, O., Ericsson, M., Carlen, M., & Tsai, L-H. (2015). Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment. J NEUROSCI, 35(6), 2372-2383.

Vancouver

Rudenko A, Seo J, Hu J, Su SC, Calderon de Anda F, Durak O et al. Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment. J NEUROSCI. 2015 Feb 11;35(6):2372-2383.

Bibtex

@article{181dd601c9b94d92aeb6d43e8dd661a5,
title = "Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment",
abstract = "Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component of various neuropsychiatric disorders; however, the mechanisms regulating PV interneurons remain mostly unknown. Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to function as a major regulator of synaptic plasticity. Here, we demonstrate that genetic ablation of Cdk5 in PV interneurons in mouse brain leads to an increase in GABAergic neurotransmission and impaired synaptic plasticity. PVCre;fCdk5 mice display a range of behavioral abnormalities, including decreased anxiety and memory impairment. Our results reveal a central role of Cdk5 expressed in PV interneurons in gating inhibitory neurotransmission and underscore the importance of such regulation during behavioral tasks. Our findings suggest that Cdk5 can be considered a promising therapeutic target in a variety of conditions attributed to inhibitory interneuronal dysfunction, such as epilepsy, anxiety disorders, and schizophrenia. ",
author = "Andrii Rudenko and Jinsoo Seo and Ji Hu and Su, {Susan C.} and {Calderon de Anda}, Froylan and Omer Durak and Maria Ericsson and Marie Carlen and Li-Huei Tsai",
year = "2015",
month = feb,
day = "11",
language = "English",
volume = "35",
pages = "2372--2383",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "6",

}

RIS

TY - JOUR

T1 - Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment

AU - Rudenko, Andrii

AU - Seo, Jinsoo

AU - Hu, Ji

AU - Su, Susan C.

AU - Calderon de Anda, Froylan

AU - Durak, Omer

AU - Ericsson, Maria

AU - Carlen, Marie

AU - Tsai, Li-Huei

PY - 2015/2/11

Y1 - 2015/2/11

N2 - Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component of various neuropsychiatric disorders; however, the mechanisms regulating PV interneurons remain mostly unknown. Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to function as a major regulator of synaptic plasticity. Here, we demonstrate that genetic ablation of Cdk5 in PV interneurons in mouse brain leads to an increase in GABAergic neurotransmission and impaired synaptic plasticity. PVCre;fCdk5 mice display a range of behavioral abnormalities, including decreased anxiety and memory impairment. Our results reveal a central role of Cdk5 expressed in PV interneurons in gating inhibitory neurotransmission and underscore the importance of such regulation during behavioral tasks. Our findings suggest that Cdk5 can be considered a promising therapeutic target in a variety of conditions attributed to inhibitory interneuronal dysfunction, such as epilepsy, anxiety disorders, and schizophrenia.

AB - Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component of various neuropsychiatric disorders; however, the mechanisms regulating PV interneurons remain mostly unknown. Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to function as a major regulator of synaptic plasticity. Here, we demonstrate that genetic ablation of Cdk5 in PV interneurons in mouse brain leads to an increase in GABAergic neurotransmission and impaired synaptic plasticity. PVCre;fCdk5 mice display a range of behavioral abnormalities, including decreased anxiety and memory impairment. Our results reveal a central role of Cdk5 expressed in PV interneurons in gating inhibitory neurotransmission and underscore the importance of such regulation during behavioral tasks. Our findings suggest that Cdk5 can be considered a promising therapeutic target in a variety of conditions attributed to inhibitory interneuronal dysfunction, such as epilepsy, anxiety disorders, and schizophrenia.

M3 - SCORING: Journal article

VL - 35

SP - 2372

EP - 2383

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 6

ER -