Long-term treatment with deferiprone in a L1 veteran.
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Long-term treatment with deferiprone in a L1 veteran. / Meo, Anna; Ruggeri, Annalisa; Rosa, La; Angela, Maria; Kordes, Uwe; Kordes, Uwe; Fischer, Roland.
in: EUR J HAEMATOL, Jahrgang 74, Nr. 6, 6, 2005, S. 523-525.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Long-term treatment with deferiprone in a L1 veteran.
AU - Meo, Anna
AU - Ruggeri, Annalisa
AU - Rosa, La
AU - Angela, Maria
AU - Kordes, Uwe
AU - Kordes, Uwe
AU - Fischer, Roland
PY - 2005
Y1 - 2005
N2 - We studied a patient with mild beta-thalassaemia major under treatment with the oral chelator deferiprone (DFP or L1) for about 10 yr (L1 veteran). Due to poor compliance with desferrioxamine, the patient started compassionate use of DFP at an age of 23 yr with a serum ferritin of 5200 microg/L. Monitoring iron overload by SQUID biosusceptometry revealed a dramatic decrease of liver iron concentrations from 4500 to 950 microg/g(liver) within 9.5 yr. A good clinical response to chelation treatment with DFP was observed together with an improvement of liver and cardiac function and a reduction in the hepatitis virus load.
AB - We studied a patient with mild beta-thalassaemia major under treatment with the oral chelator deferiprone (DFP or L1) for about 10 yr (L1 veteran). Due to poor compliance with desferrioxamine, the patient started compassionate use of DFP at an age of 23 yr with a serum ferritin of 5200 microg/L. Monitoring iron overload by SQUID biosusceptometry revealed a dramatic decrease of liver iron concentrations from 4500 to 950 microg/g(liver) within 9.5 yr. A good clinical response to chelation treatment with DFP was observed together with an improvement of liver and cardiac function and a reduction in the hepatitis virus load.
M3 - SCORING: Zeitschriftenaufsatz
VL - 74
SP - 523
EP - 525
JO - EUR J HAEMATOL
JF - EUR J HAEMATOL
SN - 0902-4441
IS - 6
M1 - 6
ER -