Long-term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma
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Long-term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma. / Rutkowski, Rico; Daeschlein, Georg; von Woedtke, Thomas; Smeets, Ralf; Gosau, Martin; Metelmann, Hans-Robert.
in: DIAGNOSTICS, Jahrgang 10, Nr. 4, 11.04.2020.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Long-term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma
AU - Rutkowski, Rico
AU - Daeschlein, Georg
AU - von Woedtke, Thomas
AU - Smeets, Ralf
AU - Gosau, Martin
AU - Metelmann, Hans-Robert
PY - 2020/4/11
Y1 - 2020/4/11
N2 - Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO2 laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required.
AB - Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO2 laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required.
U2 - 10.3390/diagnostics10040210
DO - 10.3390/diagnostics10040210
M3 - SCORING: Journal article
C2 - 32290487
VL - 10
JO - DIAGNOSTICS
JF - DIAGNOSTICS
SN - 2075-4418
IS - 4
ER -