Long-Term Prognosis of Patients With Takotsubo Syndrome
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Long-Term Prognosis of Patients With Takotsubo Syndrome. / Ghadri, Jelena R; Kato, Ken; Cammann, Victoria L; Gili, Sebastiano; Jurisic, Stjepan; Di Vece, Davide; Candreva, Alessandro; Ding, Katharina J; Micek, Jozef; Szawan, Konrad A; Bacchi, Beatrice; Bianchi, Rahel; Levinson, Rena A; Wischnewsky, Manfred; Seifert, Burkhardt; Schlossbauer, Susanne A; Citro, Rodolfo; Bossone, Eduardo; Münzel, Thomas; Knorr, Maike; Heiner, Susanne; D'Ascenzo, Fabrizio; Franke, Jennifer; Sarcon, Annahita; Napp, L Christian; Jaguszewski, Milosz; Noutsias, Michel; Katus, Hugo A; Burgdorf, Christof; Schunkert, Heribert; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Pieske, Burkert M; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuß, Gerd; Karakas, Mahir; Koenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M; Braun-Dullaeus, Ruediger C; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Empen, Klaus; Felix, Stephan B; Delmas, Clément; Lairez, Olivier; El-Battrawy, Ibrahim; Akin, Ibrahim; Borggrefe, Martin; Horowitz, John; Kozel, Martin; Tousek, Petr; Widimský, Petr; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Winchester, David E; Ukena, Christian; Bax, Jeroen J; Prasad, Abhiram; Böhm, Michael; Lüscher, Thomas F; Ruschitzka, Frank; Templin, Christian.
in: J AM COLL CARDIOL, Jahrgang 72, Nr. 8, 21.08.2018, S. 874-882.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Long-Term Prognosis of Patients With Takotsubo Syndrome
AU - Ghadri, Jelena R
AU - Kato, Ken
AU - Cammann, Victoria L
AU - Gili, Sebastiano
AU - Jurisic, Stjepan
AU - Di Vece, Davide
AU - Candreva, Alessandro
AU - Ding, Katharina J
AU - Micek, Jozef
AU - Szawan, Konrad A
AU - Bacchi, Beatrice
AU - Bianchi, Rahel
AU - Levinson, Rena A
AU - Wischnewsky, Manfred
AU - Seifert, Burkhardt
AU - Schlossbauer, Susanne A
AU - Citro, Rodolfo
AU - Bossone, Eduardo
AU - Münzel, Thomas
AU - Knorr, Maike
AU - Heiner, Susanne
AU - D'Ascenzo, Fabrizio
AU - Franke, Jennifer
AU - Sarcon, Annahita
AU - Napp, L Christian
AU - Jaguszewski, Milosz
AU - Noutsias, Michel
AU - Katus, Hugo A
AU - Burgdorf, Christof
AU - Schunkert, Heribert
AU - Thiele, Holger
AU - Bauersachs, Johann
AU - Tschöpe, Carsten
AU - Pieske, Burkert M
AU - Rajan, Lawrence
AU - Michels, Guido
AU - Pfister, Roman
AU - Cuneo, Alessandro
AU - Jacobshagen, Claudius
AU - Hasenfuß, Gerd
AU - Karakas, Mahir
AU - Koenig, Wolfgang
AU - Rottbauer, Wolfgang
AU - Said, Samir M
AU - Braun-Dullaeus, Ruediger C
AU - Banning, Adrian
AU - Cuculi, Florim
AU - Kobza, Richard
AU - Fischer, Thomas A
AU - Vasankari, Tuija
AU - Airaksinen, K E Juhani
AU - Opolski, Grzegorz
AU - Dworakowski, Rafal
AU - MacCarthy, Philip
AU - Kaiser, Christoph
AU - Osswald, Stefan
AU - Galiuto, Leonarda
AU - Crea, Filippo
AU - Dichtl, Wolfgang
AU - Empen, Klaus
AU - Felix, Stephan B
AU - Delmas, Clément
AU - Lairez, Olivier
AU - El-Battrawy, Ibrahim
AU - Akin, Ibrahim
AU - Borggrefe, Martin
AU - Horowitz, John
AU - Kozel, Martin
AU - Tousek, Petr
AU - Widimský, Petr
AU - Gilyarova, Ekaterina
AU - Shilova, Alexandra
AU - Gilyarov, Mikhail
AU - Winchester, David E
AU - Ukena, Christian
AU - Bax, Jeroen J
AU - Prasad, Abhiram
AU - Böhm, Michael
AU - Lüscher, Thomas F
AU - Ruschitzka, Frank
AU - Templin, Christian
N1 - Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2018/8/21
Y1 - 2018/8/21
N2 - BACKGROUND: Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive.OBJECTIVES: This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers.METHODS: Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions.RESULTS: Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients.CONCLUSIONS: Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (International Takotsubo Registry [InterTAK Registry]; NCT01947621).
AB - BACKGROUND: Prognosis of Takotsubo syndrome (TTS) remains controversial due to scarcity of available data. Additionally, the effect of the triggering factors remains elusive.OBJECTIVES: This study compared prognosis between TTS and acute coronary syndrome (ACS) patients and investigated short- and long-term outcomes in TTS based on different triggers.METHODS: Patients with TTS were enrolled from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with ACS. In addition, short- and long-term outcomes were compared between different groups according to triggering conditions.RESULTS: Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS patients related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas patients related to emotional stress had better outcomes compared with ACS patients.CONCLUSIONS: Overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients. Also, we demonstrated that TTS can either be benign or a life-threating condition depending on the inciting stress factor. We propose a new classification based on triggers, which can serve as a clinical tool to predict short- and long-term outcomes of TTS. (International Takotsubo Registry [InterTAK Registry]; NCT01947621).
KW - Acute Coronary Syndrome/diagnosis
KW - Aged
KW - Aged, 80 and over
KW - Electroencephalography/mortality
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Mortality/trends
KW - Nervous System Diseases/diagnosis
KW - Prognosis
KW - Registries
KW - Stress, Psychological/diagnosis
KW - Takotsubo Cardiomyopathy/diagnosis
KW - Time Factors
U2 - 10.1016/j.jacc.2018.06.016
DO - 10.1016/j.jacc.2018.06.016
M3 - SCORING: Journal article
C2 - 30115226
VL - 72
SP - 874
EP - 882
JO - J AM COLL CARDIOL
JF - J AM COLL CARDIOL
SN - 0735-1097
IS - 8
ER -