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Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91

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Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. / von Hoff, Katja; Hinkes, Bernward; Gerber, Nicolas U; Deinlein, Frank; Mittler, Uwe; Urban, Christian; Benesch, Martin; Warmuth-Metz, Monika; Soerensen, Niels; Zwiener, Isabella; Goette, Heiko; Schlegel, Paul G; Pietsch, Torsten; Kortmann, Rolf D; Kuehl, Joachim; Rutkowski, Stefan.

in: EUR J CANCER, Jahrgang 45, Nr. 7, 05.2009, S. 1209-17.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

von Hoff, K, Hinkes, B, Gerber, NU, Deinlein, F, Mittler, U, Urban, C, Benesch, M, Warmuth-Metz, M, Soerensen, N, Zwiener, I, Goette, H, Schlegel, PG, Pietsch, T, Kortmann, RD, Kuehl, J & Rutkowski, S 2009, 'Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91', EUR J CANCER, Jg. 45, Nr. 7, S. 1209-17. https://doi.org/10.1016/j.ejca.2009.01.015

APA

von Hoff, K., Hinkes, B., Gerber, N. U., Deinlein, F., Mittler, U., Urban, C., Benesch, M., Warmuth-Metz, M., Soerensen, N., Zwiener, I., Goette, H., Schlegel, P. G., Pietsch, T., Kortmann, R. D., Kuehl, J., & Rutkowski, S. (2009). Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. EUR J CANCER, 45(7), 1209-17. https://doi.org/10.1016/j.ejca.2009.01.015

Vancouver

von Hoff K, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C et al. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. EUR J CANCER. 2009 Mai;45(7):1209-17. https://doi.org/10.1016/j.ejca.2009.01.015

Bibtex

@article{f34fcf792c1443dc8c3b7871edf52106,
title = "Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91",
abstract = "PURPOSE: To analyse long-term outcome and clinical prognostic factors in medulloblastoma.METHODS: We analysed 280 patients with medulloblastoma (3-18 years) included from 1991 to 1997 in the randomised multicentre trial HIT'91 comparing pre-('sandwich') and postradiation ('maintenance') chemotherapy (median follow-up of survivors for 10 years).RESULTS: In 187 patients with complete staging, overall survival (OS) was higher after maintenance compared to sandwich treatment for M0 (10-year OS 91% and 62%, p=0.001) and M1 patients (10-year OS 70% and 34%, p=0.020). In M2/3 disease, 10-year OS was 42% and 45%. Incomplete staging, metastases, younger age and sandwich chemotherapy were independent adverse risk factors. Twelve percent of all relapses (13 of 107) occurred after more than five years, and 12 patients had secondary neoplasms.CONCLUSIONS: After maintenance therapy, long-term survival was excellent in fully assessable patients with localised medulloblastoma, and favourable for M1 patients. Patients should be followed longer for late relapses and secondary tumours.",
keywords = "Adolescent, Antineoplastic Agents, Cerebellar Neoplasms, Child, Child, Preschool, Combined Modality Therapy, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Medulloblastoma, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasm, Residual, Neoplasms, Second Primary, Proportional Hazards Models, Survival Rate, Treatment Outcome, Vincristine",
author = "{von Hoff}, Katja and Bernward Hinkes and Gerber, {Nicolas U} and Frank Deinlein and Uwe Mittler and Christian Urban and Martin Benesch and Monika Warmuth-Metz and Niels Soerensen and Isabella Zwiener and Heiko Goette and Schlegel, {Paul G} and Torsten Pietsch and Kortmann, {Rolf D} and Joachim Kuehl and Stefan Rutkowski",
year = "2009",
month = may,
doi = "10.1016/j.ejca.2009.01.015",
language = "English",
volume = "45",
pages = "1209--17",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "7",

}

RIS

TY - JOUR

T1 - Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91

AU - von Hoff, Katja

AU - Hinkes, Bernward

AU - Gerber, Nicolas U

AU - Deinlein, Frank

AU - Mittler, Uwe

AU - Urban, Christian

AU - Benesch, Martin

AU - Warmuth-Metz, Monika

AU - Soerensen, Niels

AU - Zwiener, Isabella

AU - Goette, Heiko

AU - Schlegel, Paul G

AU - Pietsch, Torsten

AU - Kortmann, Rolf D

AU - Kuehl, Joachim

AU - Rutkowski, Stefan

PY - 2009/5

Y1 - 2009/5

N2 - PURPOSE: To analyse long-term outcome and clinical prognostic factors in medulloblastoma.METHODS: We analysed 280 patients with medulloblastoma (3-18 years) included from 1991 to 1997 in the randomised multicentre trial HIT'91 comparing pre-('sandwich') and postradiation ('maintenance') chemotherapy (median follow-up of survivors for 10 years).RESULTS: In 187 patients with complete staging, overall survival (OS) was higher after maintenance compared to sandwich treatment for M0 (10-year OS 91% and 62%, p=0.001) and M1 patients (10-year OS 70% and 34%, p=0.020). In M2/3 disease, 10-year OS was 42% and 45%. Incomplete staging, metastases, younger age and sandwich chemotherapy were independent adverse risk factors. Twelve percent of all relapses (13 of 107) occurred after more than five years, and 12 patients had secondary neoplasms.CONCLUSIONS: After maintenance therapy, long-term survival was excellent in fully assessable patients with localised medulloblastoma, and favourable for M1 patients. Patients should be followed longer for late relapses and secondary tumours.

AB - PURPOSE: To analyse long-term outcome and clinical prognostic factors in medulloblastoma.METHODS: We analysed 280 patients with medulloblastoma (3-18 years) included from 1991 to 1997 in the randomised multicentre trial HIT'91 comparing pre-('sandwich') and postradiation ('maintenance') chemotherapy (median follow-up of survivors for 10 years).RESULTS: In 187 patients with complete staging, overall survival (OS) was higher after maintenance compared to sandwich treatment for M0 (10-year OS 91% and 62%, p=0.001) and M1 patients (10-year OS 70% and 34%, p=0.020). In M2/3 disease, 10-year OS was 42% and 45%. Incomplete staging, metastases, younger age and sandwich chemotherapy were independent adverse risk factors. Twelve percent of all relapses (13 of 107) occurred after more than five years, and 12 patients had secondary neoplasms.CONCLUSIONS: After maintenance therapy, long-term survival was excellent in fully assessable patients with localised medulloblastoma, and favourable for M1 patients. Patients should be followed longer for late relapses and secondary tumours.

KW - Adolescent

KW - Antineoplastic Agents

KW - Cerebellar Neoplasms

KW - Child

KW - Child, Preschool

KW - Combined Modality Therapy

KW - Drug Administration Schedule

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Medulloblastoma

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Neoplasm, Residual

KW - Neoplasms, Second Primary

KW - Proportional Hazards Models

KW - Survival Rate

KW - Treatment Outcome

KW - Vincristine

U2 - 10.1016/j.ejca.2009.01.015

DO - 10.1016/j.ejca.2009.01.015

M3 - SCORING: Journal article

C2 - 19250820

VL - 45

SP - 1209

EP - 1217

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 7

ER -