Long-Term Follow-Up and Late Effects
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Long-Term Follow-Up and Late Effects. / Hayden, Patrick; Gagelmann, Nico; Snowden, John.
The EBMT/EHA CAR-T Cell Handbook. Hrsg. / Nicolaus Kröger; John Gribben; Christian Chabannon; Ibrahim Yakoub-Agha; Hermann Einsele. 1. Aufl. Cham : Springer International Publishing, 2022. S. 183-187.Publikationen: SCORING: Beitrag in Buch/Sammelwerk › Kapitel › Forschung
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TY - CHAP
T1 - Long-Term Follow-Up and Late Effects
AU - Hayden, Patrick
AU - Gagelmann, Nico
AU - Snowden, John
PY - 2022
Y1 - 2022
N2 - Little is known about the long-term effects of CAR-T cell therapy. Although medium-term complications, such as cytopenia and hypogammaglobulinaemia, may persist and require ongoing treatment, there do not appear to be other durable toxicities specific to this new immunotherapeutic class (Fried et al. 2019; Cordeiro et al. 2020; Cappell et al. 2020). However, to date, CAR-T therapy has been evaluated in patients with multiple relapsed diseases following several lines of treatment, including allogeneic stem cell transplantation, making it difficult to identify which effects may be directly attributable to this novel treatment. Nonetheless, as the use of CAR-T cell therapy increases, structured models for survivorship care will need to be established. The factors that will affect care requirements include the primary malignancy, prior treatment, the specific CAR-T therapy and patient age and frailty.
AB - Little is known about the long-term effects of CAR-T cell therapy. Although medium-term complications, such as cytopenia and hypogammaglobulinaemia, may persist and require ongoing treatment, there do not appear to be other durable toxicities specific to this new immunotherapeutic class (Fried et al. 2019; Cordeiro et al. 2020; Cappell et al. 2020). However, to date, CAR-T therapy has been evaluated in patients with multiple relapsed diseases following several lines of treatment, including allogeneic stem cell transplantation, making it difficult to identify which effects may be directly attributable to this novel treatment. Nonetheless, as the use of CAR-T cell therapy increases, structured models for survivorship care will need to be established. The factors that will affect care requirements include the primary malignancy, prior treatment, the specific CAR-T therapy and patient age and frailty.
U2 - 10.1007/978-3-030-94353-0_36
DO - 10.1007/978-3-030-94353-0_36
M3 - Chapter
SN - 978-3-030-94352-3
SP - 183
EP - 187
BT - The EBMT/EHA CAR-T Cell Handbook
A2 - Kröger, Nicolaus
A2 - Gribben, John
A2 - Chabannon, Christian
A2 - Yakoub-Agha, Ibrahim
A2 - Einsele, Hermann
PB - Springer International Publishing
CY - Cham
ER -