Long-term effects of heroin-assisted treatment in Germany.
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Long-term effects of heroin-assisted treatment in Germany. / Verthein, Uwe; Bonorden-Kleij, Karin; Degkwitz, Peter; Dilg, Christoph; Köhler, Wilfried K; Passie, Torsten; Soyka, Michael; Tanger, Sabine; Vogel, Mario; Haasen, Christian.
in: ADDICTION, Jahrgang 103, Nr. 6, 6, 2008, S. 960-968.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Long-term effects of heroin-assisted treatment in Germany.
AU - Verthein, Uwe
AU - Bonorden-Kleij, Karin
AU - Degkwitz, Peter
AU - Dilg, Christoph
AU - Köhler, Wilfried K
AU - Passie, Torsten
AU - Soyka, Michael
AU - Tanger, Sabine
AU - Vogel, Mario
AU - Haasen, Christian
PY - 2008
Y1 - 2008
N2 - AIMS: Trials in Switzerland, the Netherlands and Spain have found that heroin-assisted treatment (HAT) as maintenance treatment for opioid-dependent patients reduces illicit drug use. A German trial also found diamorphine treatment to be superior to methadone treatment. The present study describes the association between 2 years of heroin treatment and improvements in health and social stabilization, as well as illicit drug use. DESIGN: A prospective cohort study design. PARTICIPANTS: A total of 515 patients were assigned to diamorphine treatment; 278 patients remained in the study treatment for the entire period of 24 months (54.8%). MEASUREMENTS: The results on physical (Opiate Treatment Index Health Symptoms Scale) and mental (Symptom Checklist 90-Revised Global Severity Index) health and illicit drug use (number of days with drug use within the last month-European Addiction Severity Index) were examined by repeated-measures analyses. FINDINGS: Symptoms of physical (Pillai's trace = 0.837, df = 4, P <0.001) and mental health (Pillai's trace = 0.450, df = 4, P <0.001) improved during treatment. Street heroin use declined rapidly (Pillai's trace = 0.836, df = 4, P <0.001), as did cocaine use (Pillai's trace = 0.280, df = 4, P <0.001). CONCLUSIONS: HAT is associated with improvements in mental and physical health in the long term.
AB - AIMS: Trials in Switzerland, the Netherlands and Spain have found that heroin-assisted treatment (HAT) as maintenance treatment for opioid-dependent patients reduces illicit drug use. A German trial also found diamorphine treatment to be superior to methadone treatment. The present study describes the association between 2 years of heroin treatment and improvements in health and social stabilization, as well as illicit drug use. DESIGN: A prospective cohort study design. PARTICIPANTS: A total of 515 patients were assigned to diamorphine treatment; 278 patients remained in the study treatment for the entire period of 24 months (54.8%). MEASUREMENTS: The results on physical (Opiate Treatment Index Health Symptoms Scale) and mental (Symptom Checklist 90-Revised Global Severity Index) health and illicit drug use (number of days with drug use within the last month-European Addiction Severity Index) were examined by repeated-measures analyses. FINDINGS: Symptoms of physical (Pillai's trace = 0.837, df = 4, P <0.001) and mental health (Pillai's trace = 0.450, df = 4, P <0.001) improved during treatment. Street heroin use declined rapidly (Pillai's trace = 0.836, df = 4, P <0.001), as did cocaine use (Pillai's trace = 0.280, df = 4, P <0.001). CONCLUSIONS: HAT is associated with improvements in mental and physical health in the long term.
M3 - SCORING: Zeitschriftenaufsatz
VL - 103
SP - 960
EP - 968
JO - ADDICTION
JF - ADDICTION
SN - 0965-2140
IS - 6
M1 - 6
ER -
