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Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity?

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Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity? / Blum, Katrin Sabine; Hagel, Christian; Neuen-Jacob, Eva; Herkenrath, Peter; Fiehler, Jens; Kohlschütter, Alfried; Lanfermann, Heinrich; Ding, Xiao-Qi.

in: J CHILD NEUROL, Jahrgang 27, Nr. 2, 2, 2012, S. 229-233.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Blum, KS, Hagel, C, Neuen-Jacob, E, Herkenrath, P, Fiehler, J, Kohlschütter, A, Lanfermann, H & Ding, X-Q 2012, 'Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity?', J CHILD NEUROL, Jg. 27, Nr. 2, 2, S. 229-233. <http://www.ncbi.nlm.nih.gov/pubmed/21968981?dopt=Citation>

APA

Blum, K. S., Hagel, C., Neuen-Jacob, E., Herkenrath, P., Fiehler, J., Kohlschütter, A., Lanfermann, H., & Ding, X-Q. (2012). Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity? J CHILD NEUROL, 27(2), 229-233. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21968981?dopt=Citation

Vancouver

Blum KS, Hagel C, Neuen-Jacob E, Herkenrath P, Fiehler J, Kohlschütter A et al. Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity? J CHILD NEUROL. 2012;27(2):229-233. 2.

Bibtex

@article{e0b0d3da37a64941b97e96b21e6e1e56,
title = "Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity?",
abstract = "The authors report an abnormal prolonged restricted magnetic resonance imaging (MRI) proton diffusion that persisted for more than 2 years in a 6.5-year-old boy with a progressive neurological disease characterized by developmental retardation, peripheral polyneuropathy, and bilateral optical nerve atrophy. The long-term restricted magnetic resonance imaging proton diffusion observed in diffusion-weighted magnetic resonance images indicates chronic metabolic tissue impairment in the affected white matter, whereas measurable lactate accumulation in proton magnetic resonance spectroscopy was absent, and no respiratory complex abnormality was found in muscle tissue. These findings are suggestive of a chronically disturbed regulation of energy supply triggering a {"}slow onset{"} excitotoxicity, causing chronic hypoxia and leading to slow cell death as has been postulated in certain neurodegenerative processes.",
author = "Blum, {Katrin Sabine} and Christian Hagel and Eva Neuen-Jacob and Peter Herkenrath and Jens Fiehler and Alfried Kohlsch{\"u}tter and Heinrich Lanfermann and Xiao-Qi Ding",
year = "2012",
language = "English",
volume = "27",
pages = "229--233",
journal = "J CHILD NEUROL",
issn = "0883-0738",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Long-term diffusion impairment of cerebral white matter in a degenerative disease of the central and peripheral nervous system: reflection of chronic excitotoxicity?

AU - Blum, Katrin Sabine

AU - Hagel, Christian

AU - Neuen-Jacob, Eva

AU - Herkenrath, Peter

AU - Fiehler, Jens

AU - Kohlschütter, Alfried

AU - Lanfermann, Heinrich

AU - Ding, Xiao-Qi

PY - 2012

Y1 - 2012

N2 - The authors report an abnormal prolonged restricted magnetic resonance imaging (MRI) proton diffusion that persisted for more than 2 years in a 6.5-year-old boy with a progressive neurological disease characterized by developmental retardation, peripheral polyneuropathy, and bilateral optical nerve atrophy. The long-term restricted magnetic resonance imaging proton diffusion observed in diffusion-weighted magnetic resonance images indicates chronic metabolic tissue impairment in the affected white matter, whereas measurable lactate accumulation in proton magnetic resonance spectroscopy was absent, and no respiratory complex abnormality was found in muscle tissue. These findings are suggestive of a chronically disturbed regulation of energy supply triggering a "slow onset" excitotoxicity, causing chronic hypoxia and leading to slow cell death as has been postulated in certain neurodegenerative processes.

AB - The authors report an abnormal prolonged restricted magnetic resonance imaging (MRI) proton diffusion that persisted for more than 2 years in a 6.5-year-old boy with a progressive neurological disease characterized by developmental retardation, peripheral polyneuropathy, and bilateral optical nerve atrophy. The long-term restricted magnetic resonance imaging proton diffusion observed in diffusion-weighted magnetic resonance images indicates chronic metabolic tissue impairment in the affected white matter, whereas measurable lactate accumulation in proton magnetic resonance spectroscopy was absent, and no respiratory complex abnormality was found in muscle tissue. These findings are suggestive of a chronically disturbed regulation of energy supply triggering a "slow onset" excitotoxicity, causing chronic hypoxia and leading to slow cell death as has been postulated in certain neurodegenerative processes.

M3 - SCORING: Journal article

VL - 27

SP - 229

EP - 233

JO - J CHILD NEUROL

JF - J CHILD NEUROL

SN - 0883-0738

IS - 2

M1 - 2

ER -