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Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football

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Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football. / Parivash, Sherveen N; Goubran, Maged; Mills, Brian D; Rezaii, Paymon; Thaler, Christian; Wolman, Dylan; Bian, Wei; Mitchell, Lex A; Boldt, Brian; Douglas, David; Wilson, Eugene W; Choi, Jay; Xie, Long; Yushkevich, Paul A; DiGiacomo, Phil; Wongsripuemtet, Jitsupa; Parekh, Mansi; Fiehler, Jens; Do, Huy; Lopez, Jaime; Rosenberg, Jarrett; Camarillo, David; Grant, Gerald; Wintermark, Max; Zeineh, Michael.

in: J NEUROTRAUM, Jahrgang 36, Nr. 19, 01.10.2019, S. 2762-2773.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Parivash, SN, Goubran, M, Mills, BD, Rezaii, P, Thaler, C, Wolman, D, Bian, W, Mitchell, LA, Boldt, B, Douglas, D, Wilson, EW, Choi, J, Xie, L, Yushkevich, PA, DiGiacomo, P, Wongsripuemtet, J, Parekh, M, Fiehler, J, Do, H, Lopez, J, Rosenberg, J, Camarillo, D, Grant, G, Wintermark, M & Zeineh, M 2019, 'Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football', J NEUROTRAUM, Jg. 36, Nr. 19, S. 2762-2773. https://doi.org/10.1089/neu.2018.6357

APA

Parivash, S. N., Goubran, M., Mills, B. D., Rezaii, P., Thaler, C., Wolman, D., Bian, W., Mitchell, L. A., Boldt, B., Douglas, D., Wilson, E. W., Choi, J., Xie, L., Yushkevich, P. A., DiGiacomo, P., Wongsripuemtet, J., Parekh, M., Fiehler, J., Do, H., ... Zeineh, M. (2019). Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football. J NEUROTRAUM, 36(19), 2762-2773. https://doi.org/10.1089/neu.2018.6357

Vancouver

Parivash SN, Goubran M, Mills BD, Rezaii P, Thaler C, Wolman D et al. Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football. J NEUROTRAUM. 2019 Okt 1;36(19):2762-2773. https://doi.org/10.1089/neu.2018.6357

Bibtex

@article{a59a387b050b4e98a9757bfe7eca5fef,
title = "Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football",
abstract = "Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause brain injury. The hippocampus is composed of several distinct subfields with possible differential susceptibility to injury. The aim of this study is to determine whether there are longitudinal changes in hippocampal subfield volume in collegiate football. A prospective cohort study was conducted over a 5-year period tracking 63 football and 34 volleyball male collegiate athletes. Athletes underwent high-resolution structural magnetic resonance imaging, and automated segmentation provided hippocampal subfield volumes. At baseline, football (n = 59) athletes demonstrated a smaller subiculum volume than volleyball (n = 32) athletes (-67.77 mm3; p = 0.012). A regression analysis performed within football athletes similarly demonstrated a smaller subiculum volume among those at increased concussion risk based on athlete position (p = 0.001). For the longitudinal analysis, a linear mixed-effects model assessed the interaction between sport and time, revealing a significant decrease in cornu ammonis area 1 (CA1) volume in football (n = 36) athletes without an in-study concussion compared to volleyball (n = 23) athletes (volume difference per year = -35.22 mm3; p = 0.005). This decrease in CA1 volume over time was significant when football athletes were examined in isolation from volleyball athletes (p = 0.011). Thus, this prospective, longitudinal study showed a decrease in CA1 volume over time in football athletes, in addition to baseline differences that were identified in the downstream subiculum. Hippocampal changes may be important to study in high-contact sports.",
author = "Parivash, {Sherveen N} and Maged Goubran and Mills, {Brian D} and Paymon Rezaii and Christian Thaler and Dylan Wolman and Wei Bian and Mitchell, {Lex A} and Brian Boldt and David Douglas and Wilson, {Eugene W} and Jay Choi and Long Xie and Yushkevich, {Paul A} and Phil DiGiacomo and Jitsupa Wongsripuemtet and Mansi Parekh and Jens Fiehler and Huy Do and Jaime Lopez and Jarrett Rosenberg and David Camarillo and Gerald Grant and Max Wintermark and Michael Zeineh",
year = "2019",
month = oct,
day = "1",
doi = "10.1089/neu.2018.6357",
language = "English",
volume = "36",
pages = "2762--2773",
journal = "J NEUROTRAUM",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "19",

}

RIS

TY - JOUR

T1 - Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football

AU - Parivash, Sherveen N

AU - Goubran, Maged

AU - Mills, Brian D

AU - Rezaii, Paymon

AU - Thaler, Christian

AU - Wolman, Dylan

AU - Bian, Wei

AU - Mitchell, Lex A

AU - Boldt, Brian

AU - Douglas, David

AU - Wilson, Eugene W

AU - Choi, Jay

AU - Xie, Long

AU - Yushkevich, Paul A

AU - DiGiacomo, Phil

AU - Wongsripuemtet, Jitsupa

AU - Parekh, Mansi

AU - Fiehler, Jens

AU - Do, Huy

AU - Lopez, Jaime

AU - Rosenberg, Jarrett

AU - Camarillo, David

AU - Grant, Gerald

AU - Wintermark, Max

AU - Zeineh, Michael

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause brain injury. The hippocampus is composed of several distinct subfields with possible differential susceptibility to injury. The aim of this study is to determine whether there are longitudinal changes in hippocampal subfield volume in collegiate football. A prospective cohort study was conducted over a 5-year period tracking 63 football and 34 volleyball male collegiate athletes. Athletes underwent high-resolution structural magnetic resonance imaging, and automated segmentation provided hippocampal subfield volumes. At baseline, football (n = 59) athletes demonstrated a smaller subiculum volume than volleyball (n = 32) athletes (-67.77 mm3; p = 0.012). A regression analysis performed within football athletes similarly demonstrated a smaller subiculum volume among those at increased concussion risk based on athlete position (p = 0.001). For the longitudinal analysis, a linear mixed-effects model assessed the interaction between sport and time, revealing a significant decrease in cornu ammonis area 1 (CA1) volume in football (n = 36) athletes without an in-study concussion compared to volleyball (n = 23) athletes (volume difference per year = -35.22 mm3; p = 0.005). This decrease in CA1 volume over time was significant when football athletes were examined in isolation from volleyball athletes (p = 0.011). Thus, this prospective, longitudinal study showed a decrease in CA1 volume over time in football athletes, in addition to baseline differences that were identified in the downstream subiculum. Hippocampal changes may be important to study in high-contact sports.

AB - Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause brain injury. The hippocampus is composed of several distinct subfields with possible differential susceptibility to injury. The aim of this study is to determine whether there are longitudinal changes in hippocampal subfield volume in collegiate football. A prospective cohort study was conducted over a 5-year period tracking 63 football and 34 volleyball male collegiate athletes. Athletes underwent high-resolution structural magnetic resonance imaging, and automated segmentation provided hippocampal subfield volumes. At baseline, football (n = 59) athletes demonstrated a smaller subiculum volume than volleyball (n = 32) athletes (-67.77 mm3; p = 0.012). A regression analysis performed within football athletes similarly demonstrated a smaller subiculum volume among those at increased concussion risk based on athlete position (p = 0.001). For the longitudinal analysis, a linear mixed-effects model assessed the interaction between sport and time, revealing a significant decrease in cornu ammonis area 1 (CA1) volume in football (n = 36) athletes without an in-study concussion compared to volleyball (n = 23) athletes (volume difference per year = -35.22 mm3; p = 0.005). This decrease in CA1 volume over time was significant when football athletes were examined in isolation from volleyball athletes (p = 0.011). Thus, this prospective, longitudinal study showed a decrease in CA1 volume over time in football athletes, in addition to baseline differences that were identified in the downstream subiculum. Hippocampal changes may be important to study in high-contact sports.

U2 - 10.1089/neu.2018.6357

DO - 10.1089/neu.2018.6357

M3 - SCORING: Journal article

C2 - 31044639

VL - 36

SP - 2762

EP - 2773

JO - J NEUROTRAUM

JF - J NEUROTRAUM

SN - 0897-7151

IS - 19

ER -