Local impedance guides catheter ablation in patients with ventricular tachycardia
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Local impedance guides catheter ablation in patients with ventricular tachycardia. / Münkler, Paula; Gunawardene, Melanie A; Jungen, Christiane; Klatt, Niklas; Schwarzl, Jana M; Akbulak, Ruken Ö; Dinshaw, Leon; Hartmann, Jens; Jularic, Mario; Kahle, Ann-Kathrin; Riedel, René; Merbold, Lydia; Eickholt, Christian; Willems, Stephan; Meyer, Christian.
in: J CARDIOVASC ELECTR, Jahrgang 31, Nr. 1, 01.01.2020, S. 61-69.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Local impedance guides catheter ablation in patients with ventricular tachycardia
AU - Münkler, Paula
AU - Gunawardene, Melanie A
AU - Jungen, Christiane
AU - Klatt, Niklas
AU - Schwarzl, Jana M
AU - Akbulak, Ruken Ö
AU - Dinshaw, Leon
AU - Hartmann, Jens
AU - Jularic, Mario
AU - Kahle, Ann-Kathrin
AU - Riedel, René
AU - Merbold, Lydia
AU - Eickholt, Christian
AU - Willems, Stephan
AU - Meyer, Christian
N1 - © 2019 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals, Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - AIMS: Catheter contact and local tissue characteristics are relevant information for successful radiofrequency current (RFC)-ablation. Local impedance (LI) has been shown to reflect tissue characteristics and lesion formation during RFC-ablation. Using a novel ablation catheter incorporating three mini-electrodes, we investigated LI in relation to generator impedance (GI) in patients with ventricular tachycardia (VT) and its applicability as an indicator of effective RFC-ablation.METHODS AND RESULTS: Baseline impedance, Δimpedance during ablation and drop rate (Δimpedance/time) were analyzed for 625 RFC-applications in 28 patients with recurrent VT undergoing RFC-ablation. LI was lower in scarred (87.0 Ω [79.0-95.0]) compared to healthy myocardium (97.5 Ω ([82.75-111.50]; P = .03) while GI did not differ between scarred and healthy myocardium. ΔLI was higher (18 Ω [9.4-26.0]) for VT-terminating as compared to non-terminating RFC-ablation (ΔLI 13 Ω [8.85-18.0]; P = .03), but did not differ for ΔGI between terminating vs nonterminating RFC-ablation. Correspondingly, LI drop rate was higher for RFC-ablation terminating the VT compared with RFC-ablation not terminating the VT (0.63 Ω/s [0.52-0.76] vs 0.32 Ω [0.20-0.58]; P = .008) while there was no difference for GI drop rate. ΔLI was higher in patients with nonischemic cardiomyopathy vs patients with ischemic cardiomyopathy (16 Ω [11.0-20.0] vs 11.0 Ω [7.85-17.00]; P = .003).CONCLUSION: Our findings suggest that LI is a sensitive parameter to guide RFC-ablation in patients with VT. LI indicates differences in tissue characteristics and generally is higher in patients with nonischemic cardiomyopathy. Hence, the etiology of the underlying cardiomyopathy needs to be considered when adopting LI for monitoring catheter ablation of VT.
AB - AIMS: Catheter contact and local tissue characteristics are relevant information for successful radiofrequency current (RFC)-ablation. Local impedance (LI) has been shown to reflect tissue characteristics and lesion formation during RFC-ablation. Using a novel ablation catheter incorporating three mini-electrodes, we investigated LI in relation to generator impedance (GI) in patients with ventricular tachycardia (VT) and its applicability as an indicator of effective RFC-ablation.METHODS AND RESULTS: Baseline impedance, Δimpedance during ablation and drop rate (Δimpedance/time) were analyzed for 625 RFC-applications in 28 patients with recurrent VT undergoing RFC-ablation. LI was lower in scarred (87.0 Ω [79.0-95.0]) compared to healthy myocardium (97.5 Ω ([82.75-111.50]; P = .03) while GI did not differ between scarred and healthy myocardium. ΔLI was higher (18 Ω [9.4-26.0]) for VT-terminating as compared to non-terminating RFC-ablation (ΔLI 13 Ω [8.85-18.0]; P = .03), but did not differ for ΔGI between terminating vs nonterminating RFC-ablation. Correspondingly, LI drop rate was higher for RFC-ablation terminating the VT compared with RFC-ablation not terminating the VT (0.63 Ω/s [0.52-0.76] vs 0.32 Ω [0.20-0.58]; P = .008) while there was no difference for GI drop rate. ΔLI was higher in patients with nonischemic cardiomyopathy vs patients with ischemic cardiomyopathy (16 Ω [11.0-20.0] vs 11.0 Ω [7.85-17.00]; P = .003).CONCLUSION: Our findings suggest that LI is a sensitive parameter to guide RFC-ablation in patients with VT. LI indicates differences in tissue characteristics and generally is higher in patients with nonischemic cardiomyopathy. Hence, the etiology of the underlying cardiomyopathy needs to be considered when adopting LI for monitoring catheter ablation of VT.
KW - Action Potentials
KW - Aged
KW - Cardiomyopathies/complications
KW - Catheter Ablation/adverse effects
KW - Electric Impedance
KW - Female
KW - Heart Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Tachycardia, Ventricular/diagnosis
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1111/jce.14269
DO - 10.1111/jce.14269
M3 - SCORING: Journal article
C2 - 31701589
VL - 31
SP - 61
EP - 69
JO - J CARDIOVASC ELECTR
JF - J CARDIOVASC ELECTR
SN - 1045-3873
IS - 1
ER -