Local but not long-range microstructural differences of the ventral temporal cortex in developmental prosopagnosia
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Local but not long-range microstructural differences of the ventral temporal cortex in developmental prosopagnosia. / Song, Sunbin; Garrido, Lúcia; Nagy, Zoltan; Mohammadi, Siawoosh; Steel, Adam; Driver, Jon; Dolan, Ray J; Duchaine, Bradley; Furl, Nicholas.
in: NEUROPSYCHOLOGIA, Jahrgang 78, 11.2015, S. 195-206.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Local but not long-range microstructural differences of the ventral temporal cortex in developmental prosopagnosia
AU - Song, Sunbin
AU - Garrido, Lúcia
AU - Nagy, Zoltan
AU - Mohammadi, Siawoosh
AU - Steel, Adam
AU - Driver, Jon
AU - Dolan, Ray J
AU - Duchaine, Bradley
AU - Furl, Nicholas
N1 - Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision and no history of brain damage. Prior studies using diffusion tensor imaging in small samples of subjects with DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, with one suggesting white matter differences in two major long-range tracts running through the temporal cortex, and another suggesting white matter differences confined to fibers local to ventral temporal face-specific functional regions of interest (fROIs) in the fusiform gyrus. Here, we address these inconsistent findings using a comprehensive set of analyzes in a sample of DP subjects larger than both prior studies combined (n=16). While we found no microstructural differences in long-range tracts between DP and age-matched control participants, we found differences local to face-specific fROIs, and relationships between these microstructural measures with face recognition ability. We conclude that subtle differences in local rather than long-range tracts in the ventral temporal lobe are more likely associated with developmental prosopagnosia.
AB - Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision and no history of brain damage. Prior studies using diffusion tensor imaging in small samples of subjects with DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, with one suggesting white matter differences in two major long-range tracts running through the temporal cortex, and another suggesting white matter differences confined to fibers local to ventral temporal face-specific functional regions of interest (fROIs) in the fusiform gyrus. Here, we address these inconsistent findings using a comprehensive set of analyzes in a sample of DP subjects larger than both prior studies combined (n=16). While we found no microstructural differences in long-range tracts between DP and age-matched control participants, we found differences local to face-specific fROIs, and relationships between these microstructural measures with face recognition ability. We conclude that subtle differences in local rather than long-range tracts in the ventral temporal lobe are more likely associated with developmental prosopagnosia.
U2 - 10.1016/j.neuropsychologia.2015.10.010
DO - 10.1016/j.neuropsychologia.2015.10.010
M3 - SCORING: Journal article
C2 - 26456436
VL - 78
SP - 195
EP - 206
JO - NEUROPSYCHOLOGIA
JF - NEUROPSYCHOLOGIA
SN - 0028-3932
ER -
