Liver injury and failure in critical illness
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Liver injury and failure in critical illness. / Horvatits, Thomas; Drolz, Andreas; Trauner, Michael; Fuhrmann, Valentin.
in: HEPATOLOGY, Jahrgang 70, Nr. 6, 12.2019, S. 2204-2215.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Liver injury and failure in critical illness
AU - Horvatits, Thomas
AU - Drolz, Andreas
AU - Trauner, Michael
AU - Fuhrmann, Valentin
N1 - This article is protected by copyright. All rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - The frequency of acquired liver injury and failure in critical illness has been significantly increasing over recent decades. Currently, liver injury and failure are observed in up to 20% of patients in intensive care units and are associated with significantly increased morbidity and mortality. Secondary forms of liver injury in critical illness are divided primarily into cholestatic, hypoxic, or mixed forms. Therefore, sufficient knowledge of underlying alterations (e.g., hemodynamic, inflammatory, or drug induced) is key to a better understanding of clinical manifestations, prognostic implications, as well as diagnostic and therapeutic options of acquired liver injury and failure. This review provides a structured approach for the evaluation and treatment of acquired liver injury and failure in critically ill patients.
AB - The frequency of acquired liver injury and failure in critical illness has been significantly increasing over recent decades. Currently, liver injury and failure are observed in up to 20% of patients in intensive care units and are associated with significantly increased morbidity and mortality. Secondary forms of liver injury in critical illness are divided primarily into cholestatic, hypoxic, or mixed forms. Therefore, sufficient knowledge of underlying alterations (e.g., hemodynamic, inflammatory, or drug induced) is key to a better understanding of clinical manifestations, prognostic implications, as well as diagnostic and therapeutic options of acquired liver injury and failure. This review provides a structured approach for the evaluation and treatment of acquired liver injury and failure in critically ill patients.
U2 - 10.1002/hep.30824
DO - 10.1002/hep.30824
M3 - SCORING: Review article
C2 - 31215660
VL - 70
SP - 2204
EP - 2215
JO - HEPATOLOGY
JF - HEPATOLOGY
SN - 0270-9139
IS - 6
ER -
