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LI-RADS : Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. / Vernuccio, Federica; Cannella, Roberto; Meyer, Mathias; Choudhoury, Kingshuk Roy; Gonzáles, Fernando; Schwartz, Fides R; Gupta, Rajan T; Bashir, Mustafa R; Furlan, Alessandro; Marin, Daniele.

in: AM J ROENTGENOL, Jahrgang 213, Nr. 2, 08.2019, S. W57-W65.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vernuccio, F, Cannella, R, Meyer, M, Choudhoury, KR, Gonzáles, F, Schwartz, FR, Gupta, RT, Bashir, MR, Furlan, A & Marin, D 2019, 'LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement', AM J ROENTGENOL, Jg. 213, Nr. 2, S. W57-W65. https://doi.org/10.2214/AJR.18.20979

APA

Vernuccio, F., Cannella, R., Meyer, M., Choudhoury, K. R., Gonzáles, F., Schwartz, F. R., Gupta, R. T., Bashir, M. R., Furlan, A., & Marin, D. (2019). LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. AM J ROENTGENOL, 213(2), W57-W65. https://doi.org/10.2214/AJR.18.20979

Vancouver

Vernuccio F, Cannella R, Meyer M, Choudhoury KR, Gonzáles F, Schwartz FR et al. LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. AM J ROENTGENOL. 2019 Aug;213(2):W57-W65. https://doi.org/10.2214/AJR.18.20979

Bibtex

@article{7ad61a0d0d6f4bad9894303ac1c369b5,
title = "LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement",
abstract = "OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.",
keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular/diagnostic imaging, Contrast Media, Female, Gadolinium DTPA, Humans, Liver Neoplasms/diagnostic imaging, Magnetic Resonance Imaging/methods, Male, Middle Aged, Retrospective Studies, Sensitivity and Specificity",
author = "Federica Vernuccio and Roberto Cannella and Mathias Meyer and Choudhoury, {Kingshuk Roy} and Fernando Gonz{\'a}les and Schwartz, {Fides R} and Gupta, {Rajan T} and Bashir, {Mustafa R} and Alessandro Furlan and Daniele Marin",
year = "2019",
month = aug,
doi = "10.2214/AJR.18.20979",
language = "English",
volume = "213",
pages = "W57--W65",
journal = "AM J ROENTGENOL",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "2",

}

RIS

TY - JOUR

T1 - LI-RADS

T2 - Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement

AU - Vernuccio, Federica

AU - Cannella, Roberto

AU - Meyer, Mathias

AU - Choudhoury, Kingshuk Roy

AU - Gonzáles, Fernando

AU - Schwartz, Fides R

AU - Gupta, Rajan T

AU - Bashir, Mustafa R

AU - Furlan, Alessandro

AU - Marin, Daniele

PY - 2019/8

Y1 - 2019/8

N2 - OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.

AB - OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Hepatocellular/diagnostic imaging

KW - Contrast Media

KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Liver Neoplasms/diagnostic imaging

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Sensitivity and Specificity

U2 - 10.2214/AJR.18.20979

DO - 10.2214/AJR.18.20979

M3 - SCORING: Journal article

C2 - 31039012

VL - 213

SP - W57-W65

JO - AM J ROENTGENOL

JF - AM J ROENTGENOL

SN - 0361-803X

IS - 2

ER -