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Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

Standard

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. / Heine, Markus; Fischer, Alexander W; Schlein, Christian; Jung, Caroline; Straub, Leon G; Gottschling, Kristina; Mangels, Nils; Yuan, Yucheng; Nilsson, Stefan K; Liebscher, Gudrun; Chen, Ou; Schreiber, Renate; Zechner, Rudolf; Scheja, Ludger; Heeren, Joerg.

in: CELL METAB, Jahrgang 28, Nr. 4, 02.10.2018, S. 644-655.e4.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heine, M, Fischer, AW, Schlein, C, Jung, C, Straub, LG, Gottschling, K, Mangels, N, Yuan, Y, Nilsson, SK, Liebscher, G, Chen, O, Schreiber, R, Zechner, R, Scheja, L & Heeren, J 2018, 'Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice', CELL METAB, Jg. 28, Nr. 4, S. 644-655.e4. https://doi.org/10.1016/j.cmet.2018.06.020

APA

Heine, M., Fischer, A. W., Schlein, C., Jung, C., Straub, L. G., Gottschling, K., Mangels, N., Yuan, Y., Nilsson, S. K., Liebscher, G., Chen, O., Schreiber, R., Zechner, R., Scheja, L., & Heeren, J. (2018). Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. CELL METAB, 28(4), 644-655.e4. https://doi.org/10.1016/j.cmet.2018.06.020

Vancouver

Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K et al. Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. CELL METAB. 2018 Okt 2;28(4):644-655.e4. https://doi.org/10.1016/j.cmet.2018.06.020

Bibtex

@article{ef4c258b338d4d39ad8f9741a9b4d62a,
title = "Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice",
abstract = "The coordination of the organ-specific responses regulating systemic energy distribution to replenish lipid stores in acutely activated brown adipose tissue (BAT) remains elusive. Here, we show that short-term cold exposure or acute β3-adrenergic receptor (β3AR) stimulation results in secretion of the anabolic hormone insulin. This process is diminished in adipocyte-specific Atgl-/- mice, indicating that lipolysis in white adipose tissue (WAT) promotes insulin secretion. Inhibition of pancreatic β cells abolished uptake of lipids delivered by triglyceride-rich lipoproteins into activated BAT. Both increased lipid uptake into BAT and whole-body energy expenditure in response to β3AR stimulation were blunted in mice treated with the insulin receptor antagonist S961 or lacking the insulin receptor in brown adipocytes. In conclusion, we introduce the concept that acute cold and β3AR stimulation trigger a systemic response involving WAT, β cells, and BAT, which is essential for insulin-dependent fuel uptake and adaptive thermogenesis.",
keywords = "Journal Article",
author = "Markus Heine and Fischer, {Alexander W} and Christian Schlein and Caroline Jung and Straub, {Leon G} and Kristina Gottschling and Nils Mangels and Yucheng Yuan and Nilsson, {Stefan K} and Gudrun Liebscher and Ou Chen and Renate Schreiber and Rudolf Zechner and Ludger Scheja and Joerg Heeren",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = oct,
day = "2",
doi = "10.1016/j.cmet.2018.06.020",
language = "English",
volume = "28",
pages = "644--655.e4",
journal = "CELL METAB",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

AU - Heine, Markus

AU - Fischer, Alexander W

AU - Schlein, Christian

AU - Jung, Caroline

AU - Straub, Leon G

AU - Gottschling, Kristina

AU - Mangels, Nils

AU - Yuan, Yucheng

AU - Nilsson, Stefan K

AU - Liebscher, Gudrun

AU - Chen, Ou

AU - Schreiber, Renate

AU - Zechner, Rudolf

AU - Scheja, Ludger

AU - Heeren, Joerg

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/10/2

Y1 - 2018/10/2

N2 - The coordination of the organ-specific responses regulating systemic energy distribution to replenish lipid stores in acutely activated brown adipose tissue (BAT) remains elusive. Here, we show that short-term cold exposure or acute β3-adrenergic receptor (β3AR) stimulation results in secretion of the anabolic hormone insulin. This process is diminished in adipocyte-specific Atgl-/- mice, indicating that lipolysis in white adipose tissue (WAT) promotes insulin secretion. Inhibition of pancreatic β cells abolished uptake of lipids delivered by triglyceride-rich lipoproteins into activated BAT. Both increased lipid uptake into BAT and whole-body energy expenditure in response to β3AR stimulation were blunted in mice treated with the insulin receptor antagonist S961 or lacking the insulin receptor in brown adipocytes. In conclusion, we introduce the concept that acute cold and β3AR stimulation trigger a systemic response involving WAT, β cells, and BAT, which is essential for insulin-dependent fuel uptake and adaptive thermogenesis.

AB - The coordination of the organ-specific responses regulating systemic energy distribution to replenish lipid stores in acutely activated brown adipose tissue (BAT) remains elusive. Here, we show that short-term cold exposure or acute β3-adrenergic receptor (β3AR) stimulation results in secretion of the anabolic hormone insulin. This process is diminished in adipocyte-specific Atgl-/- mice, indicating that lipolysis in white adipose tissue (WAT) promotes insulin secretion. Inhibition of pancreatic β cells abolished uptake of lipids delivered by triglyceride-rich lipoproteins into activated BAT. Both increased lipid uptake into BAT and whole-body energy expenditure in response to β3AR stimulation were blunted in mice treated with the insulin receptor antagonist S961 or lacking the insulin receptor in brown adipocytes. In conclusion, we introduce the concept that acute cold and β3AR stimulation trigger a systemic response involving WAT, β cells, and BAT, which is essential for insulin-dependent fuel uptake and adaptive thermogenesis.

KW - Journal Article

U2 - 10.1016/j.cmet.2018.06.020

DO - 10.1016/j.cmet.2018.06.020

M3 - SCORING: Journal article

C2 - 30033199

VL - 28

SP - 644-655.e4

JO - CELL METAB

JF - CELL METAB

SN - 1550-4131

IS - 4

ER -