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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. / Jaitin, Diego Adhemar; Adlung, Lorenz; Thaiss, Christoph A; Weiner, Assaf; Li, Baoguo; Descamps, Hélène; Lundgren, Patrick; Bleriot, Camille; Liu, Zhaoyuan; Deczkowska, Aleksandra; Keren-Shaul, Hadas; David, Eyal; Zmora, Niv; Eldar, Shai Meron; Lubezky, Nir; Shibolet, Oren; Hill, David A; Lazar, Mitchell A; Colonna, Marco; Ginhoux, Florent; Shapiro, Hagit; Elinav, Eran; Amit, Ido.

in: CELL, Jahrgang 178, Nr. 3, 25.07.2019, S. 686-698.e14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jaitin, DA, Adlung, L, Thaiss, CA, Weiner, A, Li, B, Descamps, H, Lundgren, P, Bleriot, C, Liu, Z, Deczkowska, A, Keren-Shaul, H, David, E, Zmora, N, Eldar, SM, Lubezky, N, Shibolet, O, Hill, DA, Lazar, MA, Colonna, M, Ginhoux, F, Shapiro, H, Elinav, E & Amit, I 2019, 'Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner', CELL, Jg. 178, Nr. 3, S. 686-698.e14. https://doi.org/10.1016/j.cell.2019.05.054

APA

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., Keren-Shaul, H., David, E., Zmora, N., Eldar, S. M., Lubezky, N., Shibolet, O., Hill, D. A., Lazar, M. A., Colonna, M., ... Amit, I. (2019). Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. CELL, 178(3), 686-698.e14. https://doi.org/10.1016/j.cell.2019.05.054

Vancouver

Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, Descamps H et al. Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. CELL. 2019 Jul 25;178(3):686-698.e14. https://doi.org/10.1016/j.cell.2019.05.054

Bibtex

@article{bc2d8ddc8cd24d9585e60f4f0084fb24,
title = "Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner",
abstract = "Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2+ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.",
keywords = "Adipose Tissue, White/metabolism, Animals, Diet, High-Fat, Glucose Intolerance, Humans, Intra-Abdominal Fat/metabolism, Lipid Metabolism/genetics, Lipids/analysis, Macrophages/cytology, Membrane Glycoproteins/deficiency, Mice, Mice, Inbred C57BL, Mice, Knockout, Monocytes/cytology, Obesity/metabolism, Receptors, Immunologic/deficiency, Signal Transduction, Single-Cell Analysis",
author = "Jaitin, {Diego Adhemar} and Lorenz Adlung and Thaiss, {Christoph A} and Assaf Weiner and Baoguo Li and H{\'e}l{\`e}ne Descamps and Patrick Lundgren and Camille Bleriot and Zhaoyuan Liu and Aleksandra Deczkowska and Hadas Keren-Shaul and Eyal David and Niv Zmora and Eldar, {Shai Meron} and Nir Lubezky and Oren Shibolet and Hill, {David A} and Lazar, {Mitchell A} and Marco Colonna and Florent Ginhoux and Hagit Shapiro and Eran Elinav and Ido Amit",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = jul,
day = "25",
doi = "10.1016/j.cell.2019.05.054",
language = "English",
volume = "178",
pages = "686--698.e14",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

AU - Jaitin, Diego Adhemar

AU - Adlung, Lorenz

AU - Thaiss, Christoph A

AU - Weiner, Assaf

AU - Li, Baoguo

AU - Descamps, Hélène

AU - Lundgren, Patrick

AU - Bleriot, Camille

AU - Liu, Zhaoyuan

AU - Deczkowska, Aleksandra

AU - Keren-Shaul, Hadas

AU - David, Eyal

AU - Zmora, Niv

AU - Eldar, Shai Meron

AU - Lubezky, Nir

AU - Shibolet, Oren

AU - Hill, David A

AU - Lazar, Mitchell A

AU - Colonna, Marco

AU - Ginhoux, Florent

AU - Shapiro, Hagit

AU - Elinav, Eran

AU - Amit, Ido

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/7/25

Y1 - 2019/7/25

N2 - Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2+ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.

AB - Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2+ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.

KW - Adipose Tissue, White/metabolism

KW - Animals

KW - Diet, High-Fat

KW - Glucose Intolerance

KW - Humans

KW - Intra-Abdominal Fat/metabolism

KW - Lipid Metabolism/genetics

KW - Lipids/analysis

KW - Macrophages/cytology

KW - Membrane Glycoproteins/deficiency

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Monocytes/cytology

KW - Obesity/metabolism

KW - Receptors, Immunologic/deficiency

KW - Signal Transduction

KW - Single-Cell Analysis

U2 - 10.1016/j.cell.2019.05.054

DO - 10.1016/j.cell.2019.05.054

M3 - SCORING: Journal article

C2 - 31257031

VL - 178

SP - 686-698.e14

JO - CELL

JF - CELL

SN - 0092-8674

IS - 3

ER -