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Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women

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Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women. / Bayer, Janine; Gläscher, Jan; Finsterbusch, Jürgen; Schulte, Laura H; Sommer, Tobias.

in: NAT COMMUN, Jahrgang 9, Nr. 1, 23.03.2018, S. 1220.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bayer, J, Gläscher, J, Finsterbusch, J, Schulte, LH & Sommer, T 2018, 'Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women', NAT COMMUN, Jg. 9, Nr. 1, S. 1220. https://doi.org/10.1038/s41467-018-03679-x

APA

Bayer, J., Gläscher, J., Finsterbusch, J., Schulte, L. H., & Sommer, T. (2018). Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women. NAT COMMUN, 9(1), 1220. https://doi.org/10.1038/s41467-018-03679-x

Vancouver

Bayer J, Gläscher J, Finsterbusch J, Schulte LH, Sommer T. Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women. NAT COMMUN. 2018 Mär 23;9(1):1220. https://doi.org/10.1038/s41467-018-03679-x

Bibtex

@article{aae7158944ab49bda9cf34bc5b41524d,
title = "Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women",
abstract = "In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2's dose-response function in the human hippocampus, we pharmacologically increased E2 levels in 125 naturally cycling women (who were in their low-hormone menstruation phase) to physiological (equivalent to menstrual cycle peak) and supraphysiological (equivalent to levels during early pregnancy) concentrations in a placebo-controlled design. Twenty-four hours after first E2 intake, we measured brain activity during encoding of neutral and negative pictures and then tested recognition memory 24 h after encoding. Here we report that E2 exhibits both a monotonically increasing relationship with hippocampal activity as well as an inverted U-shaped relationship, depending on the hippocampal region. Hippocampal activity exhibiting a U-shaped relationship inflects at supraphysiological E2 levels, suggesting that while E2 within physiological ranges stimulates hippocampal activity, supraphysiological ranges show opposite effects.",
keywords = "Journal Article",
author = "Janine Bayer and Jan Gl{\"a}scher and J{\"u}rgen Finsterbusch and Schulte, {Laura H} and Tobias Sommer",
year = "2018",
month = mar,
day = "23",
doi = "10.1038/s41467-018-03679-x",
language = "English",
volume = "9",
pages = "1220",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Linear and inverted U-shaped dose-response functions describe estrogen effects on hippocampal activity in young women

AU - Bayer, Janine

AU - Gläscher, Jan

AU - Finsterbusch, Jürgen

AU - Schulte, Laura H

AU - Sommer, Tobias

PY - 2018/3/23

Y1 - 2018/3/23

N2 - In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2's dose-response function in the human hippocampus, we pharmacologically increased E2 levels in 125 naturally cycling women (who were in their low-hormone menstruation phase) to physiological (equivalent to menstrual cycle peak) and supraphysiological (equivalent to levels during early pregnancy) concentrations in a placebo-controlled design. Twenty-four hours after first E2 intake, we measured brain activity during encoding of neutral and negative pictures and then tested recognition memory 24 h after encoding. Here we report that E2 exhibits both a monotonically increasing relationship with hippocampal activity as well as an inverted U-shaped relationship, depending on the hippocampal region. Hippocampal activity exhibiting a U-shaped relationship inflects at supraphysiological E2 levels, suggesting that while E2 within physiological ranges stimulates hippocampal activity, supraphysiological ranges show opposite effects.

AB - In animals, 17-beta-estradiol (E2) enhances hippocampal plasticity in a dose-dependent, monotonically increasing manner, but this relationship can also exhibit an inverted U-shaped function. To investigate E2's dose-response function in the human hippocampus, we pharmacologically increased E2 levels in 125 naturally cycling women (who were in their low-hormone menstruation phase) to physiological (equivalent to menstrual cycle peak) and supraphysiological (equivalent to levels during early pregnancy) concentrations in a placebo-controlled design. Twenty-four hours after first E2 intake, we measured brain activity during encoding of neutral and negative pictures and then tested recognition memory 24 h after encoding. Here we report that E2 exhibits both a monotonically increasing relationship with hippocampal activity as well as an inverted U-shaped relationship, depending on the hippocampal region. Hippocampal activity exhibiting a U-shaped relationship inflects at supraphysiological E2 levels, suggesting that while E2 within physiological ranges stimulates hippocampal activity, supraphysiological ranges show opposite effects.

KW - Journal Article

U2 - 10.1038/s41467-018-03679-x

DO - 10.1038/s41467-018-03679-x

M3 - SCORING: Journal article

C2 - 29572476

VL - 9

SP - 1220

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -