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LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

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LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. / Schmidt, Elena; Dhaouadi, Ines; Gaziano, Isabella; Oliverio, Matteo; Klemm, Paul; Awazawa, Motoharu; Mitterer, Gerfried; Fernandez-Rebollo, Eduardo; Pradas-Juni, Marta; Wagner, Wolfgang; Hammerschmidt, Philipp; Loureiro, Rute; Kiefer, Christoph; Hansmeier, Nils R; Khani, Sajjad; Bergami, Matteo; Heine, Markus; Ntini, Evgenia; Frommolt, Peter; Zentis, Peter; Ørom, Ulf Andersson; Heeren, Jörg; Blüher, Matthias; Bilban, Martin; Kornfeld, Jan-Wilhelm.

in: NAT COMMUN, Jahrgang 9, Nr. 1, 06.09.2018, S. 3622.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schmidt, E, Dhaouadi, I, Gaziano, I, Oliverio, M, Klemm, P, Awazawa, M, Mitterer, G, Fernandez-Rebollo, E, Pradas-Juni, M, Wagner, W, Hammerschmidt, P, Loureiro, R, Kiefer, C, Hansmeier, NR, Khani, S, Bergami, M, Heine, M, Ntini, E, Frommolt, P, Zentis, P, Ørom, UA, Heeren, J, Blüher, M, Bilban, M & Kornfeld, J-W 2018, 'LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat', NAT COMMUN, Jg. 9, Nr. 1, S. 3622. https://doi.org/10.1038/s41467-018-05933-8

APA

Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N. R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., ... Kornfeld, J-W. (2018). LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. NAT COMMUN, 9(1), 3622. https://doi.org/10.1038/s41467-018-05933-8

Vancouver

Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M et al. LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. NAT COMMUN. 2018 Sep 6;9(1):3622. https://doi.org/10.1038/s41467-018-05933-8

Bibtex

@article{1a1be5ae20de4ad484c4a6c89c8ee9eb,
title = "LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat",
abstract = "Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA H19 increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of H19 with BMI were also observed in humans. H19 overexpression promoted, while silencing of H19 impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo, H19 overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat H19 loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.",
keywords = "Adipose Tissue, Brown, Adipose Tissue, White, Adult, Aged, Aged, 80 and over, Animals, Diet, High-Fat, Energy Metabolism, Female, Gene Expression Regulation, Genomic Imprinting, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Obesity, RNA, Long Noncoding, Journal Article, Research Support, Non-U.S. Gov't",
author = "Elena Schmidt and Ines Dhaouadi and Isabella Gaziano and Matteo Oliverio and Paul Klemm and Motoharu Awazawa and Gerfried Mitterer and Eduardo Fernandez-Rebollo and Marta Pradas-Juni and Wolfgang Wagner and Philipp Hammerschmidt and Rute Loureiro and Christoph Kiefer and Hansmeier, {Nils R} and Sajjad Khani and Matteo Bergami and Markus Heine and Evgenia Ntini and Peter Frommolt and Peter Zentis and {\O}rom, {Ulf Andersson} and J{\"o}rg Heeren and Matthias Bl{\"u}her and Martin Bilban and Jan-Wilhelm Kornfeld",
year = "2018",
month = sep,
day = "6",
doi = "10.1038/s41467-018-05933-8",
language = "English",
volume = "9",
pages = "3622",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

AU - Schmidt, Elena

AU - Dhaouadi, Ines

AU - Gaziano, Isabella

AU - Oliverio, Matteo

AU - Klemm, Paul

AU - Awazawa, Motoharu

AU - Mitterer, Gerfried

AU - Fernandez-Rebollo, Eduardo

AU - Pradas-Juni, Marta

AU - Wagner, Wolfgang

AU - Hammerschmidt, Philipp

AU - Loureiro, Rute

AU - Kiefer, Christoph

AU - Hansmeier, Nils R

AU - Khani, Sajjad

AU - Bergami, Matteo

AU - Heine, Markus

AU - Ntini, Evgenia

AU - Frommolt, Peter

AU - Zentis, Peter

AU - Ørom, Ulf Andersson

AU - Heeren, Jörg

AU - Blüher, Matthias

AU - Bilban, Martin

AU - Kornfeld, Jan-Wilhelm

PY - 2018/9/6

Y1 - 2018/9/6

N2 - Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA H19 increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of H19 with BMI were also observed in humans. H19 overexpression promoted, while silencing of H19 impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo, H19 overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat H19 loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.

AB - Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA H19 increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of H19 with BMI were also observed in humans. H19 overexpression promoted, while silencing of H19 impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo, H19 overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat H19 loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.

KW - Adipose Tissue, Brown

KW - Adipose Tissue, White

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Animals

KW - Diet, High-Fat

KW - Energy Metabolism

KW - Female

KW - Gene Expression Regulation

KW - Genomic Imprinting

KW - Humans

KW - Male

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Middle Aged

KW - Obesity

KW - RNA, Long Noncoding

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/s41467-018-05933-8

DO - 10.1038/s41467-018-05933-8

M3 - SCORING: Journal article

C2 - 30190464

VL - 9

SP - 3622

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -