Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children.
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Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children. / Bienzle, Ulrich; Eggelte, Teunis A; Adjei, Lydia A; Dietz, Ekkehart; Ehrhardt, Stephan; Cramer, Jakob; Otchwemah, Rowland N; Mockenhaupt, Frank P.
in: TROP MED INT HEALTH, Jahrgang 10, Nr. 7, 7, 2005, S. 668-671.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children.
AU - Bienzle, Ulrich
AU - Eggelte, Teunis A
AU - Adjei, Lydia A
AU - Dietz, Ekkehart
AU - Ehrhardt, Stephan
AU - Cramer, Jakob
AU - Otchwemah, Rowland N
AU - Mockenhaupt, Frank P
PY - 2005
Y1 - 2005
N2 - Haptoglobin (Hp) polymorphisms in sub-Saharan Africa have been associated with an increased risk of severe malaria. However, available data are inconclusive. We examined the role of Hp polymorphisms in susceptibility to Plasmodium falciparum infection and to severe malaria in northern Ghana. Three groups each of 290 age and sex-matched children with severe malaria, children with asymptomatic P. falciparum infection and aparasitaemic healthy controls were studied. Hp typing was based on PCR. In all children, Hp1-1, Hp2-1, and Hp2-2 occurred in 32.4%, 54.1%, and 13.5%, respectively. The prevalence of the Hp genotypes did not differ significantly between groups. However, Hp2 alleles were least common in healthy children (0.379), more frequent in parasitaemic controls (0.402), and most common in severe malaria patients (0.434; = 3.7; P = 0.06). In matched pair analysis, no Hp genotype increased the risk of severe malaria. However, using Hp1-1 as a reference, children with Hp2-2 exhibited a slightly increased risk of severe malaria (odds ratio, 1.6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria.
AB - Haptoglobin (Hp) polymorphisms in sub-Saharan Africa have been associated with an increased risk of severe malaria. However, available data are inconclusive. We examined the role of Hp polymorphisms in susceptibility to Plasmodium falciparum infection and to severe malaria in northern Ghana. Three groups each of 290 age and sex-matched children with severe malaria, children with asymptomatic P. falciparum infection and aparasitaemic healthy controls were studied. Hp typing was based on PCR. In all children, Hp1-1, Hp2-1, and Hp2-2 occurred in 32.4%, 54.1%, and 13.5%, respectively. The prevalence of the Hp genotypes did not differ significantly between groups. However, Hp2 alleles were least common in healthy children (0.379), more frequent in parasitaemic controls (0.402), and most common in severe malaria patients (0.434; = 3.7; P = 0.06). In matched pair analysis, no Hp genotype increased the risk of severe malaria. However, using Hp1-1 as a reference, children with Hp2-2 exhibited a slightly increased risk of severe malaria (odds ratio, 1.6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria.
M3 - SCORING: Zeitschriftenaufsatz
VL - 10
SP - 668
EP - 671
JO - TROP MED INT HEALTH
JF - TROP MED INT HEALTH
SN - 1360-2276
IS - 7
M1 - 7
ER -
